Navigation Links
New key element discovered in pathogenesis of Burkitt lymphoma
Date:8/13/2012

Burkitt lymphoma is a malignant, fast-growing tumor that originates from a subtype of white blood cells called B lymphocytes of the immune system and often affects internal organs and the central nervous system. Now Dr. Sandrine Sander and Professor Klaus Rajewsky of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch have identified a key element that transforms the immune cells into malignant lymphoma cells. They developed a mouse model that closely resembles Burkitt lymphoma in humans and that may help to test new treatment strategies (Cancer Cell)*.

Burkitt lymphoma typically develops in childhood and occurs most frequently in equatorial Africa and South America. This tumor originates from germinal centers of the lymphoid organs (Peyer's patches in the small intestine, lymph nodes and spleen). The germinal center reaction is initiated by mature B cells upon detection of a foreign substance (antigen). These B cells modify their DNA in the course of the reaction, resulting finally in a highly specific antibody response against the antigen.

The B cell receptor (BCR), an antibody presented on the surface of mature B cells, plays a crucial role in the germinal center reaction. In order to optimally recognize the respective antigen and initiate an appropriate immune response, the DNA segments encoding the antibody need to be modified and rearranged. While the processes are complex, DNA breaks occur and error-prone repair mechanisms may lead to genetic mutations associated with cancer development.

It is well established that in Burkitt lymphoma, mistakes in the repair of DNA breaks result in the translocation of the c-MYC oncogene. This gene regulates cell division, and thus its expression is tightly controlled in normal cells. The c-MYC translocation leads to its deregulation, and the affected cells divide in an uncontrolled manner. However, c-MYC overexpression also leads to massive cell death. Therefore c-MYC dereg
'/>"/>

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. First direct evidence that elemental fluorine occurs in nature
2. Unexpected crustacean diversity discovered in northern freshwater ecosystems
3. University of Alberta led research may have discovered how memories are encoded in our brains
4. Newly discovered foot points to a new kid on the hominin block
5. New immune defense enzyme discovered
6. New genetic mechanism of immune deficiency discovered
7. Housekeeping mechanism for brain stem cells discovered
8. Scientists have discovered genes that increase the risk of osteoporosis and fractures
9. New form of intellectual disability discovered
10. 24 new species of lizards discovered on Caribbean islands are close to extinction
11. Key proteins newly discovered form and function may provide novel cancer treatment target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... pills in Peru found that 28 percent of ... or falsified. Many pills released the active ingredient ... One batch had no active ingredient at all. ... at the Georgia Institute of Technology developed a ... suspected counterfeit drugs and then characterize their chemical ...
(Date:4/18/2014)... researchers have published soil organic carbon sequestration rates. ... organic carbon can be sequestered by simply switching from ... there is a growing body of research with evidence ... cover crops, small grains, and forages may not be ... , "Some studies have shown that both moldboard and ...
(Date:4/18/2014)... PROVIDENCE, R.I. [Brown University] Asteroid and comet impacts ... animals on regional or even global scales. But new ... preserve the signatures of ancient life at the time ... Brown geologist Pete Schultz has found fragments of leaves ... a several ancient impacts in Argentina. The material could ...
Breaking Biology News(10 mins):Counterfeit contraceptives found in South America 2Counterfeit contraceptives found in South America 3Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3
... could be much easier for them to penetrate healthy ... at the Pharmacology Institute of the University of Heidelberg ... (suppressor of cancer cell invasion), which inhibits the movement ... the factor,s functioning was disrupted, the cancer cells moved ...
... food supplements is certainly not free of risk. Since ... of Freiburg and Gttingen have registered a total of ... capsules. The pharmacologist Dieter Mller and his coauthors describe ... of Deutsches rzteblatt International (Dtsch Arztebl Int ...
... and Identity CardsFALLS CHURCH, Va., April 7 CSC ... UK Identity and Passport Service (IPS), an executive agency ... and ID cards, has awarded the company a 10-year ... IPS application and enrollment system. The agreement has an ...
Cached Biology News:How tumor cells move 2CSC Awarded $570 Million IT Services Contract by UK Identity and Passport Service 2
(Date:1/15/2014)... 2014 More than 5 million Americans ... in 3 seniors will die with Alzheimer’s or another ... figures have shocked many Americans into looking for ways ... these tragic age-related cognitive disorders. Jonathan Weisman, president of ...
(Date:1/15/2014)... 15, 2014 DTS Language Services, Inc ... Web Portal for Life Science organizations who need document translations. ... subject matter of their documents in advance with a selection ... time-to-delivery of translations, often a critical factor in clinical and ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of ... of tinnitus. Patients listen to sound therapy that is ... of weeks to months, their tinnitus volume decreases. , AudioNotch ... Music and Notched White Noise. Now, AudioNotch is pleased to ...
(Date:1/14/2014)... Washington, DC (PRWEB) January 14, 2014 ... session for Thursday, January 23, 2014 at 2pm EST ... Actionable Knowledge.” The topic focuses on how technology can ... mission critical decisions for government agencies. The online webinar ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2DTS Improves Efficiency for Life Science Document Translations 2Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... starting in the city of Milwaukee. , ,Innovation Mondays ... the Medical College of Wisconsin and the community at large. ... ,Were taking our inspiration from the networking events I used ... Our goal is to provide an environment where people who ...
... now have a photographic memory. The bad news? Your ... secretly sourced and powerfully protected photographic memory actually, ... is again in the palm of your hands ... own computer rather than just the puny recesses of ...
... automation and IT systems for manufactuers, says it will ... Intel and that it worked with the chip manufacturer ... in a variety of embedded devices. The IXP465 ... a Rockwell statement said. The company said it will ...
Cached Biology Technology:A social event for technology entrepreneurs 2Google delves deep within your computer with new desktop tool 2Google delves deep within your computer with new desktop tool 3Google delves deep within your computer with new desktop tool 4Google delves deep within your computer with new desktop tool 5
Activating Agents, 7-azabenzotriazol-1-yloxy-tris-(pyrrolidino)phosphonium hexafluorophosphate...
... Immunogen: Fusion protein derived from ... ASIP/PAR-3 (atypical PKC isotype-specific interacting protein/ ... not related to the protease-activated-receptors also ... Xenopus (positive controls: Caco-2 MDCK A6 ...
...
Request Info...
Biology Products: