Navigation Links
New key element discovered in pathogenesis of Burkitt lymphoma
Date:8/13/2012

Burkitt lymphoma is a malignant, fast-growing tumor that originates from a subtype of white blood cells called B lymphocytes of the immune system and often affects internal organs and the central nervous system. Now Dr. Sandrine Sander and Professor Klaus Rajewsky of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch have identified a key element that transforms the immune cells into malignant lymphoma cells. They developed a mouse model that closely resembles Burkitt lymphoma in humans and that may help to test new treatment strategies (Cancer Cell)*.

Burkitt lymphoma typically develops in childhood and occurs most frequently in equatorial Africa and South America. This tumor originates from germinal centers of the lymphoid organs (Peyer's patches in the small intestine, lymph nodes and spleen). The germinal center reaction is initiated by mature B cells upon detection of a foreign substance (antigen). These B cells modify their DNA in the course of the reaction, resulting finally in a highly specific antibody response against the antigen.

The B cell receptor (BCR), an antibody presented on the surface of mature B cells, plays a crucial role in the germinal center reaction. In order to optimally recognize the respective antigen and initiate an appropriate immune response, the DNA segments encoding the antibody need to be modified and rearranged. While the processes are complex, DNA breaks occur and error-prone repair mechanisms may lead to genetic mutations associated with cancer development.

It is well established that in Burkitt lymphoma, mistakes in the repair of DNA breaks result in the translocation of the c-MYC oncogene. This gene regulates cell division, and thus its expression is tightly controlled in normal cells. The c-MYC translocation leads to its deregulation, and the affected cells divide in an uncontrolled manner. However, c-MYC overexpression also leads to massive cell death. Therefore c-MYC dereg
'/>"/>

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. First direct evidence that elemental fluorine occurs in nature
2. Unexpected crustacean diversity discovered in northern freshwater ecosystems
3. University of Alberta led research may have discovered how memories are encoded in our brains
4. Newly discovered foot points to a new kid on the hominin block
5. New immune defense enzyme discovered
6. New genetic mechanism of immune deficiency discovered
7. Housekeeping mechanism for brain stem cells discovered
8. Scientists have discovered genes that increase the risk of osteoporosis and fractures
9. New form of intellectual disability discovered
10. 24 new species of lizards discovered on Caribbean islands are close to extinction
11. Key proteins newly discovered form and function may provide novel cancer treatment target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... first week of May, 2015 and will be fulfilling ... Gino Pereira , Chief Executive Officer ... as Wocket® enters the consumer market. We would like ...
(Date:4/17/2015)... 2015 Increasing adoption ... advancement to drive biometric systems market in ... According to a recently released TechSci ... ", biometric systems market in Saudi ... at CAGR of over 22% through 2020. The ...
(Date:4/10/2015)... 10, 2015 Research and Markets ... "Security Competitive Profiles - NEC" report to ... NEC will continue to supply a range of ... with a company focus on the development of a ... Winning opportunities in the Asia-Pacific ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NEC Security Competitive Profile 2015 2
... Researchers at the Georgia Institute of Technology and the ... goal of automating the management of sedation in hospital intensive ... clinical data to accurately determine a patient,s level of sedation ... in the level. "ICU nurses have one of the ...
... more humanity acidifies and warms the world,s oceans with carbon ... our coral reefs. That,s the blunt message from a ... that ocean acidification and global warming will combine with local ... coral reefs right when they are struggling to survive. ...
... most common cardiac arrhythmia (abnormal heart rhythm). Its name ... muscles of the atria, instead of a coordinated contraction. ... in episodes lasting from minutes to weeks, or it ... alone is not in itself generally life-threatening, but it ...
Cached Biology News:Researchers working toward automating sedation in intensive care units 2Researchers working toward automating sedation in intensive care units 3Researchers working toward automating sedation in intensive care units 4Acid oceans demand greater reef care 2Moderate-to-heavy alcohol intake may increase risk of atrial fibrillation 2
(Date:5/4/2015)... 2015  Traverse Biosciences announced today that it ... agreement (CRADA) with Aratana Therapeutics Inc. (NASDAQ: ... for the treatment and control of periodontal disease ... Biosciences has also granted Aratana an exclusive option ... of periodontal disease in companion animals, inclusive of ...
(Date:5/4/2015)... , May 4, 2015 /PRNewswire/ - The ... partners are pleased to announce the formation of ... on developing treatments for cancer that harness the ... represents a unique collaboration between the Children,s Hospital ... Research Institute, McMaster University, the Ontario Institute for ...
(Date:5/4/2015)... May 04, 2015 Genedata, a ... discovery and life science research, today announced the ... latest version of its enterprise solution for biologics ... enables more efficient discovery and development of novel ... integrate and address protein optimization and developability requirements. ...
(Date:5/4/2015)...  Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the Company), ... medical needs in the areas of inflammation, oncology and ... data from three of its biodefense programs at the ... on May 12-14, 2015 to be held at the ... St. Louis MO 63101. ...
Breaking Biology Technology:Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 2Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 3Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 4Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 2Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 3Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 4Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 2Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 3Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 4Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 5Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 6Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 7Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 8Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 9Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 10Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 11Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 12
... 7 Endocare, Inc. (Nasdaq: ENDO ) ... have entered into a settlement agreement stipulating to termination ... Galil Medical pursuant to which Endocare would have acquired ... in Delaware Chancery Court. , , ...
... Covance Inc. today ... company as vice president and chief scientific officer of ... industry experience, including bioanalytical research, translational research, and talent ... development strategy for Covance,s bioanalytical services. , ...
... advanced energy research , , MONTREAL, July 7 ... technology company, today announced that it will jointly form ... Edmonton and the Alberta Energy Research Institute (AERI). , ... demonstration of novel catalytic conversion processes to produce advanced ...
Cached Biology Technology:Endocare and Galil Medical Announce Settlement of Litigation 2Covance Appoints Dr. Steven M. Michael as Vice President and Chief Scientific Officer of Global Bioanalytical Services 2Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 2Enerkem Announces World-Class Advanced Energy Research Center in Edmonton, Alberta, Canada 3
...
...
... StdSens reagents and supplies, for 10 ... sufficient to perform standard-sensitivity RNA analysis ... the Experion automated electrophoresis system. Supplied ... microliters RNA StdSens stain, 20 microliters ...
... designed for enhanced translation of cloned sequences in ... lysate. The maps for pCITE-2b(+) and pCITE-2c(+) are ... pCITE-2b(+) is a 3793 bp plasmid; it lacks ... I sites. Subtract 7 bp from all sites ...
Biology Products: