Navigation Links
New journal shows half-broken gene is enough to cause cancer
Date:11/3/2008

Tumour suppressor genes do not necessarily require both alleles to be knocked out before disease phenotypes are expressed. Research published in BioMed Central's new open access journal PathoGenetics reveals that only one allele of SMAD4 has to be damaged to put a person at risk of pancreatic and colorectal cancer.

Riccardo Fodde led a team of researchers from Erasmus MC, Rotterdam, who investigated SMAD4, a tumor suppressor gene implicated in pancreatic and colorectal cancer. They found that having one mutated SMAD4 allele was associated with the development of gastrointestinal polyps. This research is the first to address the molecular and cellular consequences of SMAD4 damage on a genome-wide scale.

This high quality research is typical of that which will be published in PathoGenetics, an open access journal created to meet the need for a resource focused solely on the pathogenesis of genetic diseases. The journal's co-Editors in Chief are Professor Stylianos Antonarakis and Professor Andrea Ballabio. Ballabio said, "PathoGenetics will give scientists a unique opportunity to publish exciting research on the molecular mechanisms underlying the manifestations of disease phenotype".

PathoGenetics will focus on both in vitro and in vivo studies on the cascade of events leading from gene mutations or genomic rearrangement to disease. The discovery of novel molecular and metabolic pathways relevant to disease pathogenesis will be given specific emphasis. The first issue includes a review by James Lupski and colleagues that deals with mechanisms for human genomic rearrangements and a groundbreaking piece on the methodology of knock-in vector construction by Nicholas Hastie and colleagues. According to Antonarakis, "Given its unique characteristics, PathoGenetics is likely to become the ideal journal for scientists from different backgrounds to publish and read exciting research on disease pathogenesis".


'/>"/>
Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-020-707-94804
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology news :

1. News tips from the Journal of Neuroscience
2. Tips from the Journals of the American Society for Microbiology
3. Story ideas from the Journal of Lipid Research
4. Highlights from the September 2007 Journal of the American Dietetic Association
5. AGU journal highlights -- Sept. 6, 2007
6. Springer will publish Journal of Coastal Conservation
7. ESA celebrates 100 years of insect science journals
8. Springer and the New York Botanical Garden Press join forces to publish botanical journals
9. 200 journals join in theme issues on poverty and human development
10. New ETH Zurich article published in scientific journal Nature
11. Media highlights in the November issues of Biophysical Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... quality of the U.S. diet showed some modest improvement ... a reduction in the consumption of unhealthy trans fats, ... the rich and the poor. , , An unhealthy ... some cancers. Eating a healthy diet is an important ... Evaluating population trends in diet quality is important because ...
(Date:9/1/2014)... revealed the presence of tiny blob-like structures that form ... don,t know what they do even though these ... crucial to the life of a cell, and therefore ... the Journal of Cell Biology , two researchers ... from biophysics to cell biology, to focus their attention ...
(Date:8/31/2014)... A fast-sensitive "electronic-nose" for sniffing the highly infectious bacteria ... stomach cramps, has been developed by a team at ... the research team has demonstrated that it is possible ... which would lead to rapid diagnosis of the ... could be possible to identify different strains of the ...
Breaking Biology News(10 mins):Quality of US diet improves, gap widens for quality between rich and poor 2Quality of US diet improves, gap widens for quality between rich and poor 3Scientists call for investigation of mysterious cloud-like collections in cells 2Scientists develop 'electronic nose' for rapid detection of C. diff infection 2
... of the peskiest household pests, while disastrous to homes, could ... Purdue University study. Mike Scharf, the O. Wayne Rollins/Orkin ... has discovered a cocktail of enzymes from the guts of ... that inhibit fuel production from woody biomass. The Scharf Laboratory ...
... A study from the microbiology lab at the Lifespan hospitals ... in identifying Clostridium difficile Toxin ( C. diff ... a molecular method detects up to 50 percent more cases ... technology is more expensive, it allows for more cases to ...
... Speculation that the welfare of a small, ... in part supported by new scientific research, according to a ... Ecosphere , a journal of the Ecological Society of America. ... whose population has plummeted over the last 15 years, has ...
Cached Biology News:Termites' digestive system could act as biofuel refinery 2Not all tests are created equal: Identifying C. diff in hospital labs 2Research bolsters importance of horseshoe crab spawning for migrating shorebirds 2
(Date:9/1/2014)... (PRWEB) September 01, 2014 The ... $1,712.1 million by 2019 from $1,070.7 million in ... 2014 to 2019. The global oligonucleotide synthesis market ... services, applications, end users, and geography. The synthesized ... growth rate in the oligonucleotide synthesis market during ...
(Date:8/31/2014)... , Aug. 31, 2014 Wockhardt Limited today ... program in Anti-Infective research when two of its drugs, ... Infectious Disease Product (QIDP) status from U.S. Food & ... which act against pathogens which have a high degree ... by Centre for Disease Control (a top U.S. government ...
(Date:8/31/2014)... 2014 2014 Market Research ... professional and in-depth research report on the ... information, including Polyacrylamide definition, classification, application, and ... overview. This research covers the international market ... global industry analysis covering macroeconomic environment & ...
(Date:8/30/2014)... TX (PRWEB) August 31, 2014 ... is a professional and in-depth study on the ... in Global and China. , The report provides ... applications and industry chain structure. Global market analysis ... a focus on history, developments, trends and competitive ...
Breaking Biology Technology:9.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 29.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 39.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 49.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 5U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3
... Technologies,Inc. (OTC Bulletin Board: BNET) announced that notification was ... Waste,Bioconversion System" has been granted by the Commonwealth of ... 2002227224. The,official filing date is approved as November 8, ... expiration date of November 8, 2021., This patent ...
... ... FUNCTIONAL FOOD market-- LAVAL, QC, Sept. 25 /PRNewswire-FirstCall/ - ... it entered a worldwide alliance with Marine Life Sciences who ... distribution,of dietary supplements and functional food products in the global,nutraceutical ...
... 25 Osteotech, Inc.,(Nasdaq: OSTE ), a leader ... announced today the appointment of Cato T.,Laurencin, M.D., Ph.D. ... of Directors effective September 24, 2008 and will serve ... Board of Directors., Kenneth P. Fallon, III, Chairman ...
Cached Biology Technology:Bion Announces Approval of New Australian Patent for Low Oxygen Organic Waste Bioconversion for Livestock Waste Environmental Treatment 2Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition 2Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition 3Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition 4Cato T. Laurencin, M.D., Ph.D. to Join Osteotech Board of Directors 2
CQCS kit for first KR 4i , (first unit)....
... Wellpro 384, compatible ... automated liquid handling system ... quickly and accurately prepares ... dilutions. The Wellpro ...
...
...
Biology Products: