Navigation Links
New insights into treatment options for patients suffering from severe alcoholic hepatitis
Date:4/16/2010

Vienna, Austria, Friday 16 April 2010: Results from two French studies presented today at the International Liver CongressTM 2010 press conference will help inform clinical practice in the treatment of patients with severe or acute alcoholic hepatitis.

The first study demonstrated the positive potential of performing liver transplantation for patients suffering from severe alcoholic hepatitis (SAH) earlier than the recommended 6-months rule (required minimum of recorded abstinence for an alcoholic patient to be eligible for a liver transplant). Indeed, those patients who do not respond to treatment with steroids have a 6-month survival of around 30% and most deaths actually occur within 2-months. The results show that early liver transplantation could be proposed to non-respondents, pending a very careful evaluation of selected patients.

Acute alcoholic hepatitis (AAH) however, is an absolute contraindication for liver transplantation. It has a low survival rate, with mortality remaining at around 35% at 6 months despite corticoid treatment, the current standard of care for the condition. The second study presented today will help inform a potential new treatment option for those patients who do not respond to standard treatment with corticoid. Data demonstrated that treatment with combined corticoids plus N-acetyl cysteine (C+NAC) showed an increase in survival rates. There have been few, large, well-designed trials advocating the use of N-acetyl cysteine to slow progression of liver disease. This latest study adds to the growing body of evidence in the benefits of treatment with C+NAC in patients with acute liver disease.

Professor Philippe Mathurin from the Hpital Huriez, CHRU Lille, France who presented the results commented: "Whilst the management of alcoholic hepatitis is steeped in controversy, as clinicians we have a responsibility to treat these patients in the most effective way possible, and as researchers we have a mandate to highlight new options.

These latest results across large patient cohorts are the sort of clinical studies that are vital to help guide best practice in the treatment pathway for difficult-to-treat patients with a challenging medical history. Alongside education and, ideally, prevention strategies we can achieve some successful outcomes."


'/>"/>

Contact: Isabelle Scali
media.easl2010@cohnwolfe.com
44-771-743-5103
European Association for the Study of the Liver
Source:Eurekalert

Related biology news :

1. Stomach stem cell discovery could bring cancer insights
2. KGI professor contributes new insights on jumping genes
3. Study involving more than 100 scientists provides new insights on green algae
4. New insights into how lasers cut flesh
5. Tumor genome analysis unveils new insights into lung cancer
6. New insights into the fate of antiparasitics in manure and manured soils
7. Hinode: new insights on the origin of solar wind
8. New mechanical insights into wound healing and scar tissue formation
9. Antarctic expedition provides new insights into the role of the Southern Ocean for global climate
10. New dinosaur from Mexico offers insights into ancient life on West America
11. New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:3/30/2017)... March 30, 2017 The research team of ... three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae ... realm of speed and accuracy for use in identification, crime investigation, ... cost. ... A research ...
Breaking Biology News(10 mins):
(Date:6/27/2017)... ... 27, 2017 , ... Indiana-based Xylogenics announced today the release ... process. The efficiencies created by the newest strain design will have an ... industry wherein individual production plants are planning to invest upwards of $350 million ...
(Date:6/26/2017)... ROCHELLE, VIRGINIA (PRWEB) , ... June 26, 2017 ... ... announced today that Melissa Kirkegaard, the former Associate Director of Product Development R&D ... successful biological and pharmaceutical products at both start-up and established biopharma companies, has ...
(Date:6/26/2017)... Va (PRWEB) , ... June 26, 2017 , ... The ... the use of health IT to create efficiencies in healthcare information exchange and a ... Donald W. Rucker, MD, head of the federal Office of the National Coordinator for ...
(Date:6/23/2017)... IA (PRWEB) , ... June 23, 2017 , ... Biova, ... Henig, Ph.D. has joined Biova’s Board of Directors. Dr. Henig will bring a wealth ... Dr. Henig has served as the Chief Technical and Scientific Officer of four major ...
Breaking Biology Technology: