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New insights into the survival and transmission strategy of malaria parasites
Date:8/13/2014

hence unable to proliferate. "Initially, we thought all parasites in our culture dish were dead," says Till Voss.

However, it turned out that over 50% of these parasites were fully viable and differentiated into gametocytes, the sexual form of the malaria parasite. Gametocytes are the only form of the parasite capable of infecting a mosquito and therefore a prerequisite to transmit malaria between humans. "Such a high sexual conversion rate is unprecedented. Usually only around 1% of parasites undergo this switch," the researcher explains.

Further experiments show that a master transcription factor triggering sexual differentiation (termed AP2-G) is expressed at much higher levels in parasites lacking HP1. Under normal conditions, HP1 silences the expression of AP2-G and thus prevents sexual conversion in most parasites.

"The switch from parasite proliferation to gametocyte differentiation is controlled epigenetically by a HP1-dependent mechanism," says Till Voss. "This is really exciting. With this knowledge in hand, and with the identification of another epigenetic regulator involved in the same process (published in the same issue of Cell Host & Microbe), we are now able to specifically track the sexual conversion pathway in molecular detail." This may pave the route for the development of new drugs preventing sexual conversion and consequently malaria transmission.


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Contact: Christian Heuss
christian.heuss@unibas.ch
41-612-848-683
Swiss Tropical and Public Health Institute
Source:Eurekalert

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