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New insights into the regulation of PTEN tumor suppression function
Date:8/20/2008

expression, either of which can force PTEN from the nucleus and prevent its ability to act as a tumor suppressor," notes Pandolfi.

"The modulation of the PML-HAUSP pathway offers us an exciting and unique approach to enhancing the tumor suppressive actions of PTEN," he adds. "Because PML is known to be 'druggable,' we believe that in cases of APL, modulation of PTEN function can be achieved with drugs already being used for the treatment of human cancers, including interferon and all trans-retinoic acid."


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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

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