Navigation Links
New insights into the immune system of the gastrointestinal tract

An international team of scientists supported by the Helmholtz Zentrum Mnchen has now discovered how this complex interaction functions and how lymphotoxin controls the production of immunoglobulins in the gut. The results are published in the latest issue of the specialist journal Science.

Naturally occurring intestinal bacteria (also known as gut flora) and an immune system comprising local immune cells maintain the immunological balance in the gastrointestinal tract. One important agent is immunoglobulin A (IgA), which is found on mucous membranes, where it renders pathogens and toxins harmless.

Lymphotoxins control the production of immunoglobulin A (IgA) and thus participate in immune responses as well as in the regular composition of the intestinal flora, the scientists report in the study. The team led by Dr. Andrey Kruglov and Professor Sergei Nedospasov from the German Rheumatism Research Center (DRFZ) Berlin, an institute of the Leibniz Association, Professor Mathias Heikenwlder from the Institute of Virology at the Helmholtz Zentrum Mnchen (HMGU) as well as other national and international partners were able to show that lymphotoxins soluble lymphotoxin alpha (sLTa3) as well as membrane-bound lymphotoxin beta (LTa1b2) induce IgA production and support the body's immune response. Lymphotoxins are inflammatory messengers that are formed by immune cells when they come into contact with pathogens. If these lymphotoxins are lacking, IgA production is reduced or even halted, resulting in changes in the intestinal flora.

"The results provide us with new insights into how the enteric immune system functions. The relationship between inflammatory messengers and the performance of the immune system helps us to understand how intestinal diseases occur", Professor Heikenwlder explains. He adds another important relevance of their results: "These insights are also important for the treatment with certain immunomodulators (such as tumor necrosis factor alpha (TNF) blockers). They bind soluble lymphotoxin and could therefore also influence IgA production and as a result upset the immunological balance."


Contact: Mathias Heikenwälder
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health

Related biology news :

1. New insights into cloud formation
2. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
3. Battle of the sexes offers evolutionary insights
4. Study provides new insights into structure of heart muscle fibers
5. Study offers new insights into the effects of stress on pregnancy
6. Cell biology -- new insights into the life of microtubules
7. Yak genome provides new insights into high altitude adaptation
8. Zebrafish provide insights into causes and treatment of human diseases
9. Feces fossils yield new insights into ancient diets and thrifty genes
10. Piglets in mazes provide insights into human cognitive development
11. The ENCODE Project publishes new genomic insights in special issue of Genome Research
Post Your Comments:
(Date:11/9/2015)... Nov. 09, 2015 ... of the "Global Law Enforcement Biometrics ... --> ) has announced ... Enforcement Biometrics Market 2015-2019" report to ... Markets ( ) has announced the ...
(Date:11/2/2015)... 2, 2015  SRI International has been awarded a ... development services to the National Cancer Institute (NCI) PREVENT ... scientific expertise, modern testing and support facilities, and analytical ... and toxicology studies to evaluate potential cancer prevention drugs. ... PREVENT Cancer Drug Development Program is an NCI-supported pipeline ...
(Date:10/29/2015)... 29, 2015 Daon, a global leader in ... released a new version of its IdentityX Platform ... North America have already installed IdentityX v4.0 ... a FIDO UAF certified server component as ... activate FIDO features. These customers include some of the ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... ... November 27, 2015 , ... Pittcon ... over 2,000 technical presentations offered in symposia, oral sessions, workshops, awards, and posters. ... a wide range of applications such as, but not limited to, biotechnology, biomedical, ...
(Date:11/26/2015)... CHESHAM , England , November 26, ... Lightpoint Medical, an innovative medical device company specializing in ... Euro grant from the European Commission as part of the ... enabling the company to carry out a large-scale clinical trial ... -->      (Logo: , ...
(Date:11/25/2015)... BRUSSELS , November 25, 2015 ... la première fois les différences entre les souches ... de celles des êtres humains . Ces ... comprendre et envisager la prise en charge efficace de ... ent diagnostiqués chez les chats .    --> ...
(Date:11/25/2015)...  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... of Neurocrine Biosciences, will be presenting at the 27th ... York . .   ... minutes prior to the presentation to download or install ... be available on the website approximately one hour after ...
Breaking Biology Technology: