Navigation Links
New insights into the immune system of the gastrointestinal tract
Date:12/9/2013

An international team of scientists supported by the Helmholtz Zentrum Mnchen has now discovered how this complex interaction functions and how lymphotoxin controls the production of immunoglobulins in the gut. The results are published in the latest issue of the specialist journal Science.

Naturally occurring intestinal bacteria (also known as gut flora) and an immune system comprising local immune cells maintain the immunological balance in the gastrointestinal tract. One important agent is immunoglobulin A (IgA), which is found on mucous membranes, where it renders pathogens and toxins harmless.

Lymphotoxins control the production of immunoglobulin A (IgA) and thus participate in immune responses as well as in the regular composition of the intestinal flora, the scientists report in the study. The team led by Dr. Andrey Kruglov and Professor Sergei Nedospasov from the German Rheumatism Research Center (DRFZ) Berlin, an institute of the Leibniz Association, Professor Mathias Heikenwlder from the Institute of Virology at the Helmholtz Zentrum Mnchen (HMGU) as well as other national and international partners were able to show that lymphotoxins soluble lymphotoxin alpha (sLTa3) as well as membrane-bound lymphotoxin beta (LTa1b2) induce IgA production and support the body's immune response. Lymphotoxins are inflammatory messengers that are formed by immune cells when they come into contact with pathogens. If these lymphotoxins are lacking, IgA production is reduced or even halted, resulting in changes in the intestinal flora.

"The results provide us with new insights into how the enteric immune system functions. The relationship between inflammatory messengers and the performance of the immune system helps us to understand how intestinal diseases occur", Professor Heikenwlder explains. He adds another important relevance of their results: "These insights are also important for the treatment with certain immunomodulators (such as tumor necrosis factor alpha (TNF) blockers). They bind soluble lymphotoxin and could therefore also influence IgA production and as a result upset the immunological balance."


'/>"/>

Contact: Mathias Heikenwälder
heikenwaelder@helmholtz-muenchen.de
49-894-140-7440
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Related biology news :

1. New insights into cloud formation
2. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
3. Battle of the sexes offers evolutionary insights
4. Study provides new insights into structure of heart muscle fibers
5. Study offers new insights into the effects of stress on pregnancy
6. Cell biology -- new insights into the life of microtubules
7. Yak genome provides new insights into high altitude adaptation
8. Zebrafish provide insights into causes and treatment of human diseases
9. Feces fossils yield new insights into ancient diets and thrifty genes
10. Piglets in mazes provide insights into human cognitive development
11. The ENCODE Project publishes new genomic insights in special issue of Genome Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... June 2, 2016 Perimeter Surveillance ... Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... will generate revenues of $17.98 billion in 2016. ... Inc, a leader in software and hardware technologies for ...
(Date:5/24/2016)... IRVINE, Calif. , May 24, 2016 Ampronix facilitates superior patient care ... LMD3251MT  3D medical LCD display is the latest premium product recently added to ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/16/2016)... May 16, 2016   EyeLock LLC , a ... the opening of an IoT Center of Excellence in ... expand the development of embedded iris biometric applications. ... of convenience and security with unmatched biometric accuracy, making ... aside from DNA. EyeLock,s platform uses video technology to ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... NC (PRWEB) , ... June 27, 2016 , ... ... just published their findings on what they believe could be a new and ... of the new research. Click here to read it now. , ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created 4Sight ... solutions to the healthcare market. The company's primary focus is on new product ... marketing strategies that are necessary to help companies efficiently bring their products to ...
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... the funding of a Sponsored Research Agreement with ... tumor cells (CTCs) from cancer patients.  The funding ... CTC levels correlate with clinical outcomes in cancer ... data will then be employed to support the ...
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
Breaking Biology Technology: