New insights into the fate of antiparasitics in manure and man...( In recent years there has been growi...)

In recent years, there has been growing interest in the question, if the entry of veterinary medicinal products (VMP) into soils via manure application is of environmental relevance. In a recent study, published in the November issue of the journal CLEAN, Kreuzig and co-workers now focused on the so far less investigated benzimidazole antiparasitics, adding valuable data to the so far available data set on fate and behavior of veterinary medicinal products in manure and manured soils.

An innovative experimental design for laboratory tests on VMP has been developed in order to simulate the real entry route of VMP into soil environments already under laboratory conditions. Degradation tests of VMP as 14C-labeled radiotracers in manures were conducted. On this basis, test manures containing 7-day aged VMP residues were prepared and then applied in laboratory batch tests to study degradation and sorption of VMP in manured soils. In further tests, the differentiation of microbial, chemical and photoinduced degradation were taken into account. Finally, test-plot experiments were performed under field conditions to monitor the transferability of the laboratory data to field conditions.

The benzimidazole antiparasitics flubendazole and fenbendazole mainly remained extractable in pig manure and soil samples. Antibiotics like sulfonamides, in contrast, rapidly formed non-extractable residues. Flubendazole was found unchanged while fenbendazole was accompanied by corresponding metabolites. Due to their slow degradation in pig manure, the manure storage is not considered to reduce substantially the environmental exposure. As shown by the sorption tests, both benzimidazoles did not fulfill the criteria of potential leachers. Finally, the degradation tests showed the dependence of the metabolic fate on the microbial activity in soil and on the test-manure application. These aspects, therefore, emphasized that the consideration of manure effects already under laborat
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