Navigation Links
New insights into the diversity of Creutzfeldt-Jakob disease agents
Date:3/17/2008

Researchers from the United Kingdom and France have identified four separate biochemical subgroups in a selection of cases of Creutzfeldt-Jakob disease. The study, published March 14th in the open-access journal PLoS Pathogens, suggests that these subgroups could represent distinct prion strains in what is the most common human prion disease.

Prion diseases are transmissible neurodegenerative disorders characterized by accumulation of an abnormal isoform (PrPSc) of a host-encoded protein (PrPC) in affected tissues. Although considered a spontaneous disorder, the clinicopathological characteristics of sporadic Creutzfeldt-Jakob disease (sCJD) are variable and substantially influenced by a particular variation in the DNA of the prion protein gene (PRNP). Due to the strong influence of host factors on the characteristics of the disease, diversity of prion agents responsible for CJD remains extremely difficult to investigate.

In this study, using two new biochemical assays, the authors identified four distinct biochemical PrPSc subgroups in 41 sCJD cases. These subgroups correlate with the current sCJD subclassification. The subgroups were also found in 12 iatrogenic CJD (iCJD) cases from different countries. Iatrogenic CJD occurs following human-to-human sCJD transmission. In contrast to the sCJD cases, however, there was no particular correlation with the PRNP codon in the iCJD cases, indicating that observed biochemical properties could be specific to the prion agent.

Further studies are required to confirm that the four biochemical subgroups identified correlate with distinct biological infectious agents.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity
2. New dinosaur from Mexico offers insights into ancient life on West America
3. Antarctic expedition provides new insights into the role of the Southern Ocean for global climate
4. New mechanical insights into wound healing and scar tissue formation
5. Hinode: new insights on the origin of solar wind
6. New insights into the fate of antiparasitics in manure and manured soils
7. Tumor genome analysis unveils new insights into lung cancer
8. New insights into how lasers cut flesh
9. Study involving more than 100 scientists provides new insights on green algae
10. KGI professor contributes new insights on jumping genes
11. Stomach stem cell discovery could bring cancer insights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2016)... Research and Markets has announced the addition of the ... their offering. ... The global bioinformatics market ... 6.21 Billion in 2016, growing at a CAGR of 21.1% during ... is driven by the growing demand for nucleic acid and protein ...
(Date:11/14/2016)... , Nov. 14, 2016  Based ... identification market, Frost & Sullivan recognizes FST ... Sullivan Award for Visionary Innovation Leadership. FST ... the biometric identification market by pioneering In ... solution for instant, seamless, and non-invasive verification. ...
(Date:6/22/2016)... Md. , June 22, 2016  The American College ... Trade Show Executive Magazine as one of the ... on May 25-27 at the Bellagio in Las ... on the highest percentage of growth in each of the ... of exhibiting companies and number of attendees. The 2015 ACMG ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... ... December 09, 2016 , ... Horses Helping Horses' ... sales to a charity, it not only donates 15%-20% of each sale to ... at the lowest factory-permitted prices. , At inception, over 50 brands comprising over 2,700 ...
(Date:12/9/2016)... (PRWEB) , ... December 09, 2016 , ... There’s a ... for 2016 by the Orange County Register, after winning the award last year as ... a sought-after employer. President and COO Daniel Vesely pointed to the tech company’s upbeat ...
(Date:12/9/2016)... (PRWEB) , ... December 09, 2016 , ... DuPont ... honored with the Breakthrough Solution of the Year Award from Platts Global Energy ... ester (FDME). The award was announced at the 18th Platts Global Energy Awards, ...
(Date:12/9/2016)... ... 09, 2016 , ... Aditya Humad, Acting CFO of AxioMed and Managing Partner ... United States, Axiomed is now gaining interest from Silicon Valley. “It was satisfying to ... went on to say that, “We expect interest to continue to rise as AxioMed ...
Breaking Biology Technology: