Navigation Links
New insights into the development of epithelial cells

Scientists of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and the Experimental and Clinical Research Center (ECRC) of MDC and Charit in Berlin-Buch have gained new insights into the development of epithelial cells and their molecular repertoire. Dr. Max Werth, Katharina Walentin and Professor Kai Schmidt-Ott have identified a transcription factor (grainyhead-like 2, Grhl2), which regulates the composition of the molecular "bridges" that link adjacent epithelial cells. The authors were able to demonstrate that Grhl2, via DNA-binding, directly regulates the expression of two such cell junctional molecules, E-cadherin and claudin 4 (Development, doi:10.1242/dev.055483)*.

This could be important for understanding the mechanisms of various diseases. For example, Grhl2-deficient mice die early in embryonic development and display defects of neural tube closure, including spina bifida.

Spina bifida is a common human congenital disease that is often associated with severe disabilities. Little is known about how the disease develops, and Grhl2 may be an important player in its pathogenesis.

Furthermore, the authors hypothesize that Grhl2 may also have important functions in internal organs, such as the kidney. Epithelial cells line the renal tubular system, which in humans is several kilometers long.

This system of renal tubules, together with the renal corpuscles, forms the basic structural and functional unit of the kidney the nephron. The human kidney filters waste products from 1700 liters of blood per day, of which 180 liters are collected as primary urine and of which finally one to two liters are excreted as urine.

The studies of the authors show that Grhl2 is produced in nephron segments that are relatively impermeable to water and solutes and that fine-tune the composition of urine.

A dysfunction of Grhl2 in these cells may affect epithelial barrier formation and other cell characteristics and, thereby, contribute to various diseases, including congenital abnormalities of the kidney or the development of hypertension.


Contact: Barbara Bachtler
Helmholtz Association of German Research Centres

Related biology news :

1. DGAC report offers food and nutrition practitioners insights on helping combat obesity epidemic
2. Squid studies provide valuable insights into hearing mechanisms
3. Insights into environmental conditions that affect highly pathogenic bird flu virus survival
4. Studies provide new insights into the genetics of obesity and fat distribution
5. New insights provide promise for development of tools to protect damaged tissues
6. Research and insights on severe asthma in children
7. New insights into how stem cells determine what tissue to become
8. Mouse stem cell study offers new insights into body fat distribution
9. Researchers share insights into RNA
10. New insights into how deadly amphibian disease spreads and kills
11. Paper offers new insights into the genomics of speciation
Post Your Comments:
(Date:11/18/2015)... PHILADELPHIA , Nov. 18, 2015  As new ... in children, doctors and other healthcare providers face challenges ... counsel families and patients. In addition, as more children ... into a patient,s adulthood and old age. ... The Children,s Hospital of Philadelphia (CHOP) . ...
(Date:11/17/2015)... 17, 2015 Paris ... --> Paris , qui s,est ... DERMALOG, le leader de l,innovation biométrique, a inventé le ... et empreintes sur la même surface de balayage. Jusqu,ici, ... l,autre pour les empreintes digitales. Désormais, un seul scanner ...
(Date:11/16/2015)... JOSE, Calif. , Nov 16, 2015 /PRNewswire/ ... developer of human interface solutions, today announced expansion ... Synaptics TouchView ™ touch controller and display ... architectural revolution of smartphones. These new TDDI products ... include TD4100 (HD resolution), TD4302 (WQHD resolution), and ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , ... November 25, 2015 , ... ... uBiome, were featured on AngelList early in their initial angel funding process. Now, ... syndicate for individuals looking to make early stage investments in the microbiome space. ...
(Date:11/24/2015)... DIEGO , Nov. 24, 2015 Halozyme Therapeutics, Inc. ... Healthcare Conference in New York on Wednesday, ... Helen Torley , president and CEO, will provide a corporate ... New York at 1:00 p.m. ET/10:00 a.m. PT ... and investor relations, will provide a corporate overview. --> ...
(Date:11/24/2015)... QUEBEC CITY , Nov. 24, 2015 /PRNewswire/ - ... the request of IIROC on behalf of the Toronto ... this news release there are no corporate developments that ... price. --> --> ... --> . --> Aeterna Zentaris ...
(Date:11/24/2015)... ... ... The Academy of Model Aeronautics (AMA), led by its Executive Council, has officially ... to represent the First–Person View (FPV) racing community. , FPV racing has exploded in ... racing and several new model aviation pilots have joined the community because of their ...
Breaking Biology Technology: