Navigation Links
New insights into the development of epithelial cells

Scientists of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and the Experimental and Clinical Research Center (ECRC) of MDC and Charit in Berlin-Buch have gained new insights into the development of epithelial cells and their molecular repertoire. Dr. Max Werth, Katharina Walentin and Professor Kai Schmidt-Ott have identified a transcription factor (grainyhead-like 2, Grhl2), which regulates the composition of the molecular "bridges" that link adjacent epithelial cells. The authors were able to demonstrate that Grhl2, via DNA-binding, directly regulates the expression of two such cell junctional molecules, E-cadherin and claudin 4 (Development, doi:10.1242/dev.055483)*.

This could be important for understanding the mechanisms of various diseases. For example, Grhl2-deficient mice die early in embryonic development and display defects of neural tube closure, including spina bifida.

Spina bifida is a common human congenital disease that is often associated with severe disabilities. Little is known about how the disease develops, and Grhl2 may be an important player in its pathogenesis.

Furthermore, the authors hypothesize that Grhl2 may also have important functions in internal organs, such as the kidney. Epithelial cells line the renal tubular system, which in humans is several kilometers long.

This system of renal tubules, together with the renal corpuscles, forms the basic structural and functional unit of the kidney the nephron. The human kidney filters waste products from 1700 liters of blood per day, of which 180 liters are collected as primary urine and of which finally one to two liters are excreted as urine.

The studies of the authors show that Grhl2 is produced in nephron segments that are relatively impermeable to water and solutes and that fine-tune the composition of urine.

A dysfunction of Grhl2 in these cells may affect epithelial barrier formation and other cell characteristics and, thereby, contribute to various diseases, including congenital abnormalities of the kidney or the development of hypertension.


Contact: Barbara Bachtler
Helmholtz Association of German Research Centres

Related biology news :

1. DGAC report offers food and nutrition practitioners insights on helping combat obesity epidemic
2. Squid studies provide valuable insights into hearing mechanisms
3. Insights into environmental conditions that affect highly pathogenic bird flu virus survival
4. Studies provide new insights into the genetics of obesity and fat distribution
5. New insights provide promise for development of tools to protect damaged tissues
6. Research and insights on severe asthma in children
7. New insights into how stem cells determine what tissue to become
8. Mouse stem cell study offers new insights into body fat distribution
9. Researchers share insights into RNA
10. New insights into how deadly amphibian disease spreads and kills
11. Paper offers new insights into the genomics of speciation
Post Your Comments:
(Date:11/4/2015)... 2015 --> ... by Transparency Market Research "Home Security Solutions Market - Global ... - 2022", the global home security solutions market is expected to ... The market is estimated to expand at a CAGR ... 2022. Rising security needs among customers at homes, the ...
(Date:10/29/2015)... , Oct. 29, 2015  Rubicon Genomics, ... for U.S. distribution of its DNA library preparation ... and Rubicon,s new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq ... the preparation of NGS libraries for liquid biopsies--the ... diagnostic and prognostic applications in cancer and other ...
(Date:10/27/2015)... 27, 2015 Munich, Germany ... Mapping technology (ASGM) automatically maps data from mobile eye ... , so that they can be quantitatively analyzed ... Munich, Germany , October 28-29, 2015. SMI,s ... from mobile eye tracking videos created with SMI,s ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... InSphero AG, the leading supplier ... models, has promoted Melanie Aregger to serve as Chief Operating Officer. , ... the management team and was promoted to Head of InSphero Diagnostics in ...
(Date:11/24/2015)... 2015 /CNW Telbec/ - ProMetic Life Sciences Inc. (TSX: PLI) ... Pierre Laurin , President and Chief Executive Officer of ... Piper Jaffray 27 th Annual Healthcare Conference to be ... 2015. st , at 8.50am (ET) and ... the day. The presentation will be available live via a ...
(Date:11/24/2015)... , Nov. 24, 2015 HemoShear ... on discovering drugs for metabolic disorders, announced today ... to its Board of Directors (BOD). Mr. Watkins ... of Human Genome Sciences (HGS), and also served ... Jim Powers , Chairman and CEO ...
(Date:11/24/2015)... YORK , November 24, 2015 ... in a European healthcare ... which the companies will work closely together in identifying European ... unmet medical need. The collaboration is underpinned by a significant ... fund. This is the first investment by Bristol-Myers Squibb in ...
Breaking Biology Technology: