Navigation Links
New insights into the development of epithelial cells
Date:10/29/2010

Scientists of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and the Experimental and Clinical Research Center (ECRC) of MDC and Charit in Berlin-Buch have gained new insights into the development of epithelial cells and their molecular repertoire. Dr. Max Werth, Katharina Walentin and Professor Kai Schmidt-Ott have identified a transcription factor (grainyhead-like 2, Grhl2), which regulates the composition of the molecular "bridges" that link adjacent epithelial cells. The authors were able to demonstrate that Grhl2, via DNA-binding, directly regulates the expression of two such cell junctional molecules, E-cadherin and claudin 4 (Development, doi:10.1242/dev.055483)*.

This could be important for understanding the mechanisms of various diseases. For example, Grhl2-deficient mice die early in embryonic development and display defects of neural tube closure, including spina bifida.

Spina bifida is a common human congenital disease that is often associated with severe disabilities. Little is known about how the disease develops, and Grhl2 may be an important player in its pathogenesis.

Furthermore, the authors hypothesize that Grhl2 may also have important functions in internal organs, such as the kidney. Epithelial cells line the renal tubular system, which in humans is several kilometers long.

This system of renal tubules, together with the renal corpuscles, forms the basic structural and functional unit of the kidney the nephron. The human kidney filters waste products from 1700 liters of blood per day, of which 180 liters are collected as primary urine and of which finally one to two liters are excreted as urine.

The studies of the authors show that Grhl2 is produced in nephron segments that are relatively impermeable to water and solutes and that fine-tune the composition of urine.

A dysfunction of Grhl2 in these cells may affect epithelial barrier formation and other cell characteristics and, thereby, contribute to various diseases, including congenital abnormalities of the kidney or the development of hypertension.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. DGAC report offers food and nutrition practitioners insights on helping combat obesity epidemic
2. Squid studies provide valuable insights into hearing mechanisms
3. Insights into environmental conditions that affect highly pathogenic bird flu virus survival
4. Studies provide new insights into the genetics of obesity and fat distribution
5. New insights provide promise for development of tools to protect damaged tissues
6. Research and insights on severe asthma in children
7. New insights into how stem cells determine what tissue to become
8. Mouse stem cell study offers new insights into body fat distribution
9. Researchers share insights into RNA
10. New insights into how deadly amphibian disease spreads and kills
11. Paper offers new insights into the genomics of speciation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced Design ... will feature emerging and evolving technology through its ... Summits will run alongside the expo portion of the ... panels and demonstrations focused on trending topics within 3D ... design and manufacturing event will take place June 13-15, 2017 ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... 2017 , ... The Academy of Model Aeronautics (AMA) will host Aviation Adventure ... take place from 9 a.m. to 2 p.m. at the International Aeromodeling Center in ... Aviation Adventure Day will be packed with entertaining activities for the entire family. Attendees ...
(Date:7/17/2017)... ... July 17, 2017 , ... OHAUS Corporation, a leading worldwide ... its new line of Heavy-Duty Orbital Shakers today. , Eight New Models Available, ... laboratory applications. These shakers are ideal for load capacities from 35 to ...
(Date:7/17/2017)... ... 17, 2017 , ... Panitch Schwarze Belisario & Nadel ... BiG (Biomedical Innovation Group) annual meeting in China. , This year’s meeting, held ... T-cell) therapy, a rapidly developing highly personalized anti-cancer technology that involves removing some ...
(Date:7/17/2017)... ... 2017 , ... DuPont Pioneer today announced the launch of ... dedicated to connecting third-party innovators with DuPont Pioneer scientists is now available and ... and digital solutions. , “DuPont Pioneer is building on its long history of ...
Breaking Biology Technology: