Navigation Links
New insights into the 'borderline personality' brain
Date:1/17/2013

New work by University of Toronto Scarborough researchers gives the best description yet of the neural circuits that underlie a severe mental illness called Borderline Personality Disorder (BPD), and could lead to better treatments and diagnosis.

The work shows that brain regions that process negative emotions (for example, anger and sadness) are overactive in people with BPD, while brain regions that would normally help damp down negative emotions are underactive.

People with BPD tend to have unstable and turbulent emotions which can lead to chaotic relationships with others, and which put them at higher risk than average for suicide. A number of brain imaging studies have found differences in the function of brains of people with BPD, but some of the studies have been contradictory.

A team led by Anthony C. Ruocco, assistant professor in the Department of Psychology and program in neuroscience, analyzed data from 11 previously published studies and confirmed a number of important differences between people with BPD and those without.

On the one hand, a brain area called the insula which helps determine how intensely we experience negative emotions is hyperactive in people with BPD. On the other hand, regions in the frontal part of the brain which are thought to help us control our emotional reactions are underactive.

"It's not just that they have too much drive from their emotions," Ruocco says. "They seem to have less of the 'brakes' to try to curb those emotions and to help regulate their intensity."

The findings fit well with symptoms seen in people with BPD, Ruocco says. "The hallmark symptom that people describe is emotion dysregulation -- you're happy one moment, and the next moment you're feeling angry or sad or depressed. People with BPD can cycle through emotions, usually negative ones, quite rapidly."

More important is how the findings might be useful in diagnosis and treatment.
'/>"/>

Contact: Don Campbell
dcampbell@utsc.utoronto.ca
416-208-2938
University of Toronto Scarborough
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study offers new insights into the mechanics of muscle fatigue
2. New insights into how immune system fights atherosclerosis
3. Study offers insights into role of muscle weakness in Down syndrome
4. Basketball teams offer insights into building strategic networks
5. Research provides new insights into dogs natural feeding behavior and finds they target a daily dietary intake that is high in fat
6. Insights into a new therapy for a rare form of cystic fibrosis
7. Notre Dame research could provide new insights into tuberculosis and other diseases
8. The ENCODE Project publishes new genomic insights in special issue of Genome Research
9. Piglets in mazes provide insights into human cognitive development
10. Feces fossils yield new insights into ancient diets and thrifty genes
11. Zebrafish provide insights into causes and treatment of human diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insights into the 'borderline personality' brain
(Date:9/21/2014)... In recent years, new strains of bacteria have emerged ... these superbugs, including drug-resistant forms of tuberculosis and staphylococcus, ... at least 23,000. Despite the urgent need for new ... antibiotics in the past decade. , MIT engineers have ... Using a gene-editing system that can disable any target ...
(Date:9/21/2014)... barnacles secrete very sticky proteins that help them cling ... these natural adhesives, a team of MIT engineers has ... ships or help heal wounds and surgical incisions. , ... engineered bacteria to produce a hybrid material that incorporates ... protein found in biofilms slimy layers formed by ...
(Date:9/19/2014)... Jimmy Durante of dinosaurs a newly discovered ... new dinosaur, named Rhinorex condrupus by ... Young University, lived in what is now Utah ... Cretaceous period. , Rhinorex, which translates roughly into ... relative of other Cretaceous hadrosaurs like Parasaurolophus and ...
Breaking Biology News(10 mins):Battling superbugs 2Battling superbugs 3Battling superbugs 4Engineered proteins stick like glue -- even in water 2Engineered proteins stick like glue -- even in water 3New hadrosaur noses into spotlight 2
... The U.S. Department of Energys Office of Science ... publication, Facilities for the Future of Science: A Twenty-Year ... in deploying the scientific facilities and instruments that the ... the frontiers of science and support the Departments missions. ...
... -- Growing recognition of the importance of health as ... has prompted the Proceedings of the National Academy of ... Health to its existing section on Sustainable Development. The ... editorial by Barry R. Bloom, Dean of the Harvard ...
... has published recent findings that reveal some of the factors underlying ... The paper, Stem Cell Aging is Controlled both Intrinsically and ... issue of Cell Stem Cell. Lei Pan, Predoctoral Researcher, and Ting ... respectively. It is widely ...
Cached Biology News:DOE publishes update of plan: 'Facilities for the Future of Science: A 20-Year Outlook' 2DOE publishes update of plan: 'Facilities for the Future of Science: A 20-Year Outlook' 3DOE publishes update of plan: 'Facilities for the Future of Science: A 20-Year Outlook' 4DOE publishes update of plan: 'Facilities for the Future of Science: A 20-Year Outlook' 5Data on life expectancy show many countries clustered in high mortality traps 2Data on life expectancy show many countries clustered in high mortality traps 3Stowers Institute's Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging 2
(Date:9/22/2014)... Philadelphia, Pa. (PRWEB) September 22, 2014 ... develops rapid diagnostics for the food and beverage ... assay will be distributed under a non-exclusive agreement ... products and services. , Enartis, an Esseco Group ... BRETT to winemakers in California and other global ...
(Date:9/22/2014)... The US markets on Friday, September 19, ... Jones Industrial Average finished at 17,279.74, up 0.08% and ... S&P 500 finished the session 0.05% lower at 2,010.40. ... finished on a positive note. The S&P 500 Health ... 0.10%, with the index gaining 6.95% in the previous ...
(Date:9/21/2014)... time, scientists have discovered how to produce ultra-thin "diamond ... greater than that of today,s strongest nanotubes and polymers. ... led by John V. Badding, a professor of chemistry ... 21 September 2014 issue of the journal Nature ... our discovery is intriguing because the threads we formed ...
(Date:9/19/2014)... -- InterMune, Inc. (Nasdaq: ITMN ) today announced ... settle the litigation in the Delaware Court of Chancery ... as of August 22, 2014, among Roche Holdings, Inc., ... of the Memorandum of Understanding, the Company agreed to ... exhibit reflecting the amendment to the Company,s Schedule 14D-9 ...
Breaking Biology Technology:Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 2Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 5Smallest possible diamonds form ultra-thin nanothreads 2Smallest possible diamonds form ultra-thin nanothreads 3Smallest possible diamonds form ultra-thin nanothreads 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19
... 2011 Pharmaceutical organizations rely heavily on internal ... Faced with a constantly evolving communication environment, companies ... with the most appropriate tactic. It ... is the most effective approach for the many ...
... discovery of a new class of dual-acting antimalarial compounds - ... Science online, at the Science Express website ... and blood infections, attacking the Plasmodium parasite at both stages ... how scientists developed a novel assay to determine liver stage ...
... Today BioSpace , the leading life sciences employment ... Campaign , marking the 7th edition. ... highlights leading organizations across the northwestern United States and ... electronic and printed campaign map that is ...
Cached Biology Technology:Internal and External Communications Excellence for the Pharmaceutical Industry: Increasing Organizational Effectiveness 2Dual-acting class of antimalarial compounds discovered with potential to prevent and treat malaria 2Dual-acting class of antimalarial compounds discovered with potential to prevent and treat malaria 3BioSpace Spotlights Northwest's Life Science Community 2