Navigation Links
New insights into the 'borderline personality' brain
Date:1/17/2013

New work by University of Toronto Scarborough researchers gives the best description yet of the neural circuits that underlie a severe mental illness called Borderline Personality Disorder (BPD), and could lead to better treatments and diagnosis.

The work shows that brain regions that process negative emotions (for example, anger and sadness) are overactive in people with BPD, while brain regions that would normally help damp down negative emotions are underactive.

People with BPD tend to have unstable and turbulent emotions which can lead to chaotic relationships with others, and which put them at higher risk than average for suicide. A number of brain imaging studies have found differences in the function of brains of people with BPD, but some of the studies have been contradictory.

A team led by Anthony C. Ruocco, assistant professor in the Department of Psychology and program in neuroscience, analyzed data from 11 previously published studies and confirmed a number of important differences between people with BPD and those without.

On the one hand, a brain area called the insula which helps determine how intensely we experience negative emotions is hyperactive in people with BPD. On the other hand, regions in the frontal part of the brain which are thought to help us control our emotional reactions are underactive.

"It's not just that they have too much drive from their emotions," Ruocco says. "They seem to have less of the 'brakes' to try to curb those emotions and to help regulate their intensity."

The findings fit well with symptoms seen in people with BPD, Ruocco says. "The hallmark symptom that people describe is emotion dysregulation -- you're happy one moment, and the next moment you're feeling angry or sad or depressed. People with BPD can cycle through emotions, usually negative ones, quite rapidly."

More important is how the findings might be useful in diagnosis and treatment. One challenge is that BPD often occurs with other disorders, such as major depression, which can make it harder to identify and treat.

The new results raise the possibility that brain imaging could be used to make a more definitive diagnosis of BPD. In the future it might also help determine what treatments are most likely to be effective for an individual patient, based on what the imaging studies show about their brain function before they even begin treatment, Ruocco says.


'/>"/>
Contact: Don Campbell
dcampbell@utsc.utoronto.ca
416-208-2938
University of Toronto Scarborough
Source:Eurekalert  

Related biology news :

1. Study offers new insights into the mechanics of muscle fatigue
2. New insights into how immune system fights atherosclerosis
3. Study offers insights into role of muscle weakness in Down syndrome
4. Basketball teams offer insights into building strategic networks
5. Research provides new insights into dogs natural feeding behavior and finds they target a daily dietary intake that is high in fat
6. Insights into a new therapy for a rare form of cystic fibrosis
7. Notre Dame research could provide new insights into tuberculosis and other diseases
8. The ENCODE Project publishes new genomic insights in special issue of Genome Research
9. Piglets in mazes provide insights into human cognitive development
10. Feces fossils yield new insights into ancient diets and thrifty genes
11. Zebrafish provide insights into causes and treatment of human diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insights into the 'borderline personality' brain
(Date:2/2/2016)... Feb. 2, 2016   Parabon NanoLabs ... U.S. Army Research Office and the Defense Forensics ... sensitivity of the company,s Snapshot Kinship Inference ... and, more generally, defense-related DNA forensics.  Although Snapshot ... (predicting appearance and ancestry from DNA evidence), it ...
(Date:2/1/2016)... , Feb. 1, 2016  Today, the first day ... announced plans to develop a first of its kind ... of IBM Watson. In the first application of ... (NYSE: IBM ), and Welltok will create a ... assessments with cognitive analytics, delivered on Welltok,s health optimization ...
(Date:1/27/2016)... , Jan. 27, 2016  Rite Track, Inc. ... in West Chester, Ohio announced ... winning service staff, based in Austin, Texas ... and ability to provide modifications, installations and technical support ... , CEO of PLUS, commented, "PLUS has provided world ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 11, 2016 --> ... "Company") (OTCQB: PSID), a life sciences company focused ... Thermomedics subsidiary, which markets the Caregiver® FDA-cleared non-contact ... in January 2016, including entering into agreements with ... sales growth, and establishing several near-term pipeline opportunities. ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... 150 years, continues today to pursue the highest level of accuracy and quality ... the AR9 Refractometer and the AR5 Refractometer. Accurate, reliable and tough enough ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... of its new stem cell treatment clinic in Quito, Ecuador. The new facility ... and trauma applications to patients from around the world. , The new ...
(Date:2/10/2016)... 2016 Early-career researchers from ... , Uganda and Yemen ... and nutrition   Indonesia , Nepal ... and Yemen are being honored for their accomplishments ... also celebrated for mentoring young women scientists who are pursuing careers in ...
Breaking Biology Technology: