Navigation Links
New insights into progressive hearing loss
Date:4/12/2009

In parallel studies in human and mouse, two groups of researchers have come to the same conclusion: that a new kind of gene is associated with progressive hearing loss. The new gene - called a microRNA - is a tiny fragment of RNA that affects the production of hundreds of other molecules within sensory hair cells of the inner ear.

The research provides important new genetic understanding of a condition that is common in humans but remains poorly understood.

One team, led by researchers from the Hospital Ramn y Cajal, Madrid, Spain, followed families who showed hearing loss. The second team, led by researchers from the Wellcome Trust Sanger Institute, Cambridge, UK, examined a new line of mice, called diminuendo, that showed progressive hearing loss from an early age. The two groups shared their emerging data.

"We were able quite quickly to show that if the mice carried one copy of the gene variant they suffered progressive hearing loss, if they carried two variants they were profoundly deaf," explains Professor Karen Steel, principal investigator of the programme at the Wellcome Trust Sanger Institute. "The important questions were could we determine what the variant is and how does it exert its effect on hearing?"

In their studies of families with progressive hearing loss, the Spanish team had proposed that the gene responsible lay on human chromosome 7. Both teams set about sequencing every gene in the equivalent genomic regions in human and mouse identified as implicated in hearing loss; the sequencing showed that most of the genes in the region could not be responsible for hearing loss.

However, they each found that a mutation in a microRNA gene called miR-96 was associated with the hearing loss.

"We know of a number of genes involved in deafness in humans and mice but, to our great surprise, this was one of a new class of genes called microRNAs," explains Professor Miguel Angel Moreno-Pelayo, senior
'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-077-537-75397
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Stomach stem cell discovery could bring cancer insights
2. KGI professor contributes new insights on jumping genes
3. Study involving more than 100 scientists provides new insights on green algae
4. New insights into how lasers cut flesh
5. Tumor genome analysis unveils new insights into lung cancer
6. New insights into the fate of antiparasitics in manure and manured soils
7. Hinode: new insights on the origin of solar wind
8. New mechanical insights into wound healing and scar tissue formation
9. Antarctic expedition provides new insights into the role of the Southern Ocean for global climate
10. New dinosaur from Mexico offers insights into ancient life on West America
11. New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... A new GSA Bulletin study uses ... Rio Puerco and Chaco Wash in northern New Mexico, ... salt cedar and willow, investigators were able to precisely ... They then combined this data with aerial imagery, LiDAR, ... of these arroyos. , Arroyos are deep, oversized channels ...
(Date:9/18/2014)... novel robotic system that can operate inside the bore ... part of a biomedical research partnership program at Brigham ... determining if the robot, in conjunction with real-time MRI ... less costly, and less discomforting for the patient. The ... cancer therapies with greater precision. , Developed by a ...
(Date:9/18/2014)... The fall foliage season that prompts millions of Americans to ... later and possibly last a little longer within a century, ... leaf peeping in some areas of the United States as ... report in the journal Global Ecology and Biogeography . ... that is the state tree of New Hampshire could ...
Breaking Biology News(10 mins):Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4
... (miRNAs) tiny strands of non-protein-coding RNAs start ... strands get chopped up by a special kind of ... shorter functional form. The resulting miRNAs bind to messenger ... thus regulating the levels of hundreds of different proteins. ...
... development is affected by nature or nurture our genetic ... we live, according to research funded by the Medical Research ... today in the journal Molecular Psychiatry , researchers from ... of Psychiatry studied data from over 6,700 families relating to ...
... June 11, 2012 /PRNewswire-iReach/ -- FirstMark, the ... Prediman K. (PK) Shah has joined it,s Scientific Advisory ... Cedars-Sinai Professorial Series, and Director of the Division of ... Atherosclerosis Research Center at Cedars-Sinai Medical Center where he ...
Cached Biology News:Living microprocessor tunes in to feedback 2Nature or nurture? It may depend on where you live 2Nature or nurture? It may depend on where you live 3FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisor Board 2FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisor Board 3
(Date:9/19/2014)... Life is rarely simple. From crop yields to disease ... usually those considered "complex traits." Just as for heightthe ... a particular human disease are shaped by multiple genetic ... genes involved. To track down such genes, geneticists typically ... a large mouse and a small mouseand then study ...
(Date:9/19/2014)... Jose, California (PRWEB) September 19, 2014 ... Nanotechnology and its potential to revolutionize the world ... agencies, multinational corporations and small start-ups. The early ... funded research projects largely due to the high ... investments. Government budgets earmarked for this evolving technology ...
(Date:9/19/2014)... 2014  Nektar Therapeutics (NASDAQ: NKTR ... the analgesic profiles of a series of the ... molecules. The preclinical research candidates were created using ... The analgesic properties of kappa receptor agonism ... Kappa opioid receptors are expressed in the ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Barnhardt ... Product Label for its Organic Cotton . The ... amount of renewable biobased ingredients meets or exceeds levels ... materials composed in whole or in significant part of ... will allow our Organic cotton to be immediately identified ...
Breaking Biology Technology:Want to link genes to complex traits? Start with more diversity 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2
... 31 Cardinal Health, a,global provider of products ... health care, today announced a three-year agreement with,Prime ... managers,to serve as its primary supply chain partner ... Prime Therapeutics managed more than $8.2 billion in ...
... Pa., July 31 The Quigley,Corporation (Nasdaq: QGLY ... million, for the second quarter ended June 30, 2008,compared ... June 30,2007. For the six months ended June 30, ... reported for the six months ended June 30, 2007., ...
... Inc. (Nasdaq: ALXA ) announced today that it ... 30, 2008, on Wednesday,August 6, 2008, following the close ... investor conference call to discuss the financial,results and other ... day, Thursday, August 7, 2008. A replay of the ...
Cached Biology Technology:Cardinal Health, Prime Therapeutics Sign Primary Distribution Agreement 2The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 2The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 3The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 4The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 5The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 6Alexza to Announce 2008 Second Quarter Financial Results and Update Its Clinical Pipeline on Wednesday, August 6, 2008 2Alexza to Announce 2008 Second Quarter Financial Results and Update Its Clinical Pipeline on Wednesday, August 6, 2008 3
... F-12 was developed for culturing hybrid cells ... modification consists of doubling the amino acids ... salt concentrations have been altered as well. ... per liter, which may render it unsuitable ...
... The EpiTect Bisulfite Kit enables ... uracils in less than 6 hours. ... innovative protection against DNA degradation and ... to guarantee fast and reliable results ...
... for routine procedures. Hollandes contains formaldehyde for ... decalcify small bone specimens. Tissue that is ... with most stains, and the cupric acetate ... membranes and cosinophil and endocrine cell granules ...
... CHEMICON's In Vitro Osteogenesis Assay Kit ... MC3T3-E1cells to a mature osteoblastic lineage, as ... this kit provides all the necessary reagents ... a standard plate reader. This product is ...
Biology Products: