Navigation Links
New insights into neuroblastoma tumor suppressor may provide clues for improved treatment
Date:8/12/2013

August 12, 2013, New York, NY Loss of a gene required for stem cells in the brain to turn into neurons may underlie the most severe forms of neuroblastoma, a deadly childhood cancer of the nervous system, according to a Ludwig Cancer Research study. Published in Developmental Cell today, the findings also provide clues about how to improve the treatment of this often-incurable tumor.

Neuroblastoma can appear in nervous tissue in the abdomen, chest and spine, among other regions of the body, and can spawn body-wracking metastasis. The most severe tumors respond poorly to treatment, and the disease accounts for 15 percent of cancer deaths in children.

Johan Holmberg, PhD, at the Ludwig Institute for Cancer Research Stockholm took a close look at the role of the CHD5 tumor suppressor during normal nervous system development. Previous studies had shown that the gene CHD5 is often inactivated in the most severe forms of neuroblastoma, but little was known about its function in healthy tissue or how it operates. The study, which was conducted in close collaboration with colleagues at Trinity College, Dublin, Ireland, addressed these two key issues.

The researchers found that CHD5 is required for the cellular transition from a stem cell to a mature neuron. In one experiment, the researchers knocked down the CHD5 gene by injecting a small RNA into the brains of fetal mice while in the womb.

"The result was a complete absence of neurons," says Ludwig researcher Holmberg who is based at the Karolinska Institutet. "Instead of becoming neurons, the cells with CHD5 knocked down stayed in a limbo-like state between an actively-dividing stem cell and a mature nerve cell. It was a very robust effect," added Holmberg.

The researchers also dissected how CHD5 operates, showing that it sticks to certain modifications of histone proteins. These modifications help control how genes are turned on and off. In the absenc
'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. UCLA life scientists present new insights on climate change and species interactions
2. Insights into deadly coral bleaching could help preserve reefs
3. New insights into how genes turn on and off
4. New insights into the development of the heart
5. Peach genome offers insights into breeding strategies for biofuels crops
6. Novel insights into the evolution of protein networks
7. Insights into the immune system, from the fates of individual T cells
8. Study offers new insights on invasive fly threatening US fruit crops
9. Pig brain models provide insights into human cognitive development
10. Misplaced molecules: New insights into the causes of dementia
11. Study provides insights into plant evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... Ill. Antarctic fishes that manufacture their own ... Ocean also suffer an unfortunate side effect, researchers ... their bodies resist melting even when temperatures warm. ... Proceedings of the National Academy of Sciences ... an undesirable consequence of the evolution of antifreeze ...
(Date:9/22/2014)... burn in Khabarovsk Krai, a territory occupying the coastline of ... plumes of smoke mark active fires. The smoke, which appears ... Sea of Okhotsk. Taiga and tundra are found ... central depression, and deciduous forests are the natural vegetation in ... in the summer, the 2014 wildfire season appears to be ...
(Date:9/22/2014)... may be at greater risk for stress-related diseases ... according to a new study by Brandeis University. ... trigger biological responses similar to the effects of ... is an important part of our body,s healing ... life-threatening diseases. , In a recently published ...
Breaking Biology News(10 mins):Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 2Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 3Obesity and stress pack a double hit for health 2
... in preserving and promoting a healthy cardiovascular system than ... researchers at the Medical College of Wisconsin in Milwaukee. ... the scientific journal Hypertension, was led by David D. ... medicine and physiology, and senior associate dean of research ...
... the red jungle fowl, but new research from Uppsala University ... more complicated than that. The researchers mapped ... found to their surprise that this genetic heredity derives from ... study is being published today in the Web edition of ...
... Option for Voluntary Use of Biometrics, WASHINGTON, ... Legal Workforce today applauded the introduction of,legislation viewed ... system and to helping prevent unauthorized,employment, a key ... The New Employee Verification Act (NEVA) introduced today ...
Cached Biology News:New study shows low-fat diets more likely to reduce risk of heart disease than low-carb diets 2Darwin was wrong about the wild origin of the chicken 2HR Initiative Endorses Bill to Create an Effective, Mandatory Federal Employment Verification System 2HR Initiative Endorses Bill to Create an Effective, Mandatory Federal Employment Verification System 3
(Date:9/22/2014)... 2014 Follow us on ... biopolymers available in abundance in nature. These natural ... such as shells of crustaceans. The significant commercial ... to the high percentage of nitrogen present compared ... various industries owing to its exclusive properties such ...
(Date:9/22/2014)... Mass. and TORONTO ... Corporation ( www.generex.com ) (OTCBB:GNBT) today announced that ... Health Network (UHN) pursuant to which UHN,s Centre ... the Company,s buccal insulin refinement project.  The goal ... bioavailability of Generex Oral-lyn™, the Company,s proprietary buccal ...
(Date:9/22/2014)... The US markets on Friday, ... the Dow Jones Industrial Average finished at 17,279.74, up ... 0.30%. The S&P 500 finished the session 0.05% lower ... ten sectors finished on a positive note. The S&P ... 751.48, up 0.10%, with the index gaining 6.95% in ...
(Date:9/21/2014)... in Switzerland have succeeded in observing the "forbidden" ... first time. These extremely weak spectra offer perspectives ... may also contribute to the development of molecular ... in the scientific journal Nature Physics . ... matter and light, is probably the most important ...
Breaking Biology Technology:Emergence of New Application Areas to Drive the Global Chitin and Chitosan Market, According to New Report by Global Industry Analysts, Inc. 2Emergence of New Application Areas to Drive the Global Chitin and Chitosan Market, According to New Report by Global Industry Analysts, Inc. 3Generex Collaborates with University Health Network for Buccal Insulin Project 2Generex Collaborates with University Health Network for Buccal Insulin Project 3Generex Collaborates with University Health Network for Buccal Insulin Project 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 5Uncovering the forbidden side of molecules 2
... MATK ) today announced its financial results ... 2008. Revenues for the fourth,quarter were $90.4 million, up ... 2007. Net income was $10.5 million, or $0.31 per ... with $18.3 million, or $0.55 per,diluted share, in last ...
... Myngle,( http://www.myngle.com ), the global language platform, ... at the Europe Unlimited,s European Venture Summit,(EVS) ( ... EVS is a showcase for the most ... energy entrepreneurs from all over Europe to meet,and ...
... Health-focused social networks,blogs, wikis and community ... but can be their biggest opportunities. A ... discuss increasing,importance of reputation monitoring and management ... User Generated Content and Enhancing its Impact,on ...
Cached Biology Technology:Martek Announces Fourth Quarter and FY 2008 Financial Results 2Martek Announces Fourth Quarter and FY 2008 Financial Results 3Martek Announces Fourth Quarter and FY 2008 Financial Results 4Martek Announces Fourth Quarter and FY 2008 Financial Results 5Martek Announces Fourth Quarter and FY 2008 Financial Results 6Martek Announces Fourth Quarter and FY 2008 Financial Results 7Martek Announces Fourth Quarter and FY 2008 Financial Results 8Martek Announces Fourth Quarter and FY 2008 Financial Results 9Martek Announces Fourth Quarter and FY 2008 Financial Results 10Martek Announces Fourth Quarter and FY 2008 Financial Results 11Myngle Best ICT Company at the European Ventures Summit 2Exclusive Conference on Managing Your Online Brand: Shaping the Noise from the Blogosphere 2
Human M-CSF...
Human IL-19 MAb (Clone 152112)...
Mouse Activin RIB/ALK-4 MAb (Clone 207304)...
... (1995) This book contains up ... current issues relating to the aetiology and ... have been made recently which greatly improve ... molecular neuropathology through clinical and diagnostic aspects, ...
Biology Products: