Navigation Links
New insights into cancer evolution help define screening window of opportunity
Date:12/4/2013

no mutations ― even after years of exposure to stomach acid.

But in patients who ultimately progressed to esophageal cancer, Reid and his colleagues saw a sudden change about four years prior to cancer diagnosis. These cells seemed to tip suddenly toward a cancerous path, undergoing large, catastrophic mutations such as deletions of long stretches of chromosomes or doubling of entire genomes. This was contrary to what Reid expected to find. "We thought we'd find a fast rate of mutation [in progressors] and a slow rate [in non-progressors]," he said, noting that the striking findings are in keeping with recent observations by other researchers. Other studies examining ovarian, prostate, breast, and colon cancer have observed a pattern of drastic mutations and genome doubling.

Because the findings seem to be generalizable to other types of cancers, Reid is optimistic that they are a first step toward better screening and prevention strategies. The four-year window in which BE cells take a turn for the malignant should reassure patients, Reid said. It gives physicians plenty of time to identify cancerous cells, and findings like Reid's and others' are giving researchers a better picture of how to detect premalignant cells as they begin to progress toward cancer.

It may be that researchers will identify even earlier, smaller mutations that presage these cells' malignant future, extending the window of opportunity by several years. Additionally, research into less invasive screening tests may well make invasive screening methods like endoscopies a thing of the past.

Ideally, Reid noted, researchers will discover ways to stop precancerous cells before the tipping point. Such interventions may be as simple as popping a few aspirin, as research by Reid and his colleagues has already demonstrated that high-risk BE patients who use aspirin and non-steroidal anti-inflammatories cut their esophageal cancer risk by about half. "If something like that cou
'/>"/>

Contact: Deborah Bach
media@fredhutch.org
206-667-2210
Fred Hutchinson Cancer Research Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. A study on cell migration provides insights into the movement of cancer cells
2. Global map provides new insights into land use
3. Physicists provide new insights into coral skeleton formation
4. New insights into DNA repair process may spur better cancer therapies
5. Erratic proteins: New insights into a transport mechanism
6. Eyewear Market 2014 Insights and System Refresher Report
7. Global analysis reveals new insights into the ribosome -- with important implications for disease
8. Potential diagnostic marker for zinc status offers insights into the effects of zinc deficiency
9. New insights into neuroblastoma tumor suppressor may provide clues for improved treatment
10. UCLA life scientists present new insights on climate change and species interactions
11. Insights into deadly coral bleaching could help preserve reefs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insights into cancer evolution help define screening window of opportunity
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Global Wearable Technologies Market and Applications, ... Trends and Forecast 2014-2020" report to their ... smart devices that can be worn on the ...
(Date:12/22/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... mobile commerce market, announces it has retained famous pickpocket, entertainer ... International CES debut of the Wocket™ biometric smart wallet.  ... NXT-ID booth January 6th and 7 th , 2015, demonstrating ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... to survive? The answer changes depending on climate, and some ... sprouts. Stanford researchers have found that the formation of ... meaning mouth) is controlled by a specific signaling pathway that ... The findings are described in a paper published Nov. 14 ...
... Nov. 24 M2SYS Technology, an award-winning,fingerprint ... that,InvoTech Systems Inc., the leading provider of ... industry, has chosen M2SYS Technology to,provide ... software and with M2SYS, M2-EasyScan(TM) optical fingerprint,reader. ...
... (NIST) announced today that it is awarding grants totaling ... cost-shared support for the construction of new scientific research ... in a special competition announced last spring. The ... the University of California at Berkeley for the build-out ...
Cached Biology News:Key link in how plants adapt to climate discovered by Stanford researchers 2InvoTech Selects M2SYS Technology for Leading-Edge Fingerprint Software Solution 2NIST awards $24M in grants for new research facilities 2NIST awards $24M in grants for new research facilities 3NIST awards $24M in grants for new research facilities 4NIST awards $24M in grants for new research facilities 5
(Date:1/23/2015)... Portal Solutions , a technology consulting ... Microsoft Office 365 and SharePoint platforms , today announces its ... being one of the region’s fastest-growing mid-sized companies based on ... , “To be recognized a second year in a row ...
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... 2015 Cambridge Semantics, the leading provider of ... that 2014 was a record-breaking year across the board for ... Anzo Smart Data Platform and our Smart Data solutions, our ... diverse data which led to record growth for the company ...
(Date:1/22/2015)... Crystal Diagnostics (CDx) Xpress System, a rapid ... AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. coli ... to as STEC or the “Big-6”) as well as Escherichia ... per 325 g of raw ground beef and raw beef ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... February 29, 2012 TREM Rx, Inc., a biotechnology ... to the skin, announced today the results of an in ... powerful cells of the immune system called TREMs (T Resident ... protective immune response that is far stronger than memory T ...
... has been shown to significantly improve the chances of pregnancy ... a Newcastle team of fertility experts at the University and ... a totally enclosed and controlled environment within which every step ... published today in the journal PLoS ONE reveals ...
... 2012 ARUP Laboratories, a leading national clinical and ... laboratory research and development, announced the establishment of a ... ) The new division is designed to ... enhance our ability to diversify into new market segments. ...
Cached Biology Technology:Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 2Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 3Increased fertility rate for IVF patients achieved by new equipment design 2ARUP Laboratories Announces Creation of Business Innovations Division 2
... HT96 Isothermal Block is an anodized aluminum, ... plates and to provide efficient thermal transfer ... new design of the HT96 Isothermal Block ... enhanced product design allowing for compatibility with ...
...
...
...
Biology Products: