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New insights into a leading poultry disease and its risks to human health
Date:1/27/2009

to harmful pathogens by their ability to transfer from their own host bacteria into new recipient bacteria. By analyzing the DNA sequence of plasmid pAPEC-1 and testing the mechanism of transfer of pAPEC-1, Mellata and her team have discovered a new way that plasmids use to move from one bacteria to another. This system consists of hijacking the transfer machinery of other helper plasmids present in the same bacteria.

To create a vaccine for the USDA project, the APEC genes would be shuttled into the Salmonella bacteria in the hopes of triggering a protective immune response against both Salmonella and E. coli. This double duty vaccine could protect people not only against the increased risk of APEC causing human illness, but also against the most common food-borne illness, Salmonella.

Mellata feels that now that her team has identified many of the APEC gene targets they will use, it represents the end of the beginning of their research journey to develop a vaccine that will provide improved poultry health, an economic benefit to producers and enhanced food safety.

"The problem right now is understanding the virulence of APEC as well as Salmonella to find a way that will protect against all types of the bacteria," said Mellata.


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Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

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New insights into a leading poultry disease and its risks to human health
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