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New insights come from tracing cells that irreversibly scar lungs
Date:12/1/2011

hey multiplied, migrated within the lung, or differentiated into another cell type.

Paul Noble, M.D., co-author and chief of the Pulmonary Division at Duke, said that identifying the source of the lethal expansion of the scarring (fibroblast) cells is a critical missing link in understanding disease progression.

Previous studies had suggested that the epithelial cells in the alveoli are a source of fibroblast accumulation after lung injury, he said.

This study used the newest tracing approaches to conclusively demonstrate, however, that the alveolar epithelium isnt a significant source for fibroblast accumulation following lung injury in mice, Noble said. The studies suggest that there may be several sources for the scar-forming cell accumulation in fibrosis, including pericytes, which hadnt been implicated in lung fibrosis until now.

Noble said that the study data provide new insights into the sources of scar-forming cells and would help to target the correct cell population that causes disease progression.

Now the researchers are focusing on what these cells may make that could promote a healing process. One idea is that perhaps in IPF these epithelial cells have lost the ability to repair damage to the lung, so that scarring continues inexorably and cannot be restrained perhaps we could find a way to assist the repair process, Hogan said. Promoting the healing process might be another therapeutic approach.


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Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

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