Navigation Links
New insight into the mechanisms of voltage sensing and transduction in biological processes
Date:9/14/2007

The voltage sensor of voltage-gated ion channels is a conserved protein domain that senses millivolt changes in transmembrane potential, to regulate ion permeation through the channel. A recently discovered protein, Ci-VSP, has a voltage sensor that is coupled not to an ion channel but to a phosphatidylinositide phosphosphatase, the activity of which depends on membrane potential.

In a new paper published in The Journal of Physiology, Murata and Okamura, from the Okazaki Institute for Integrative Bioscience, examine a voltage-sensitive phosphatase that converts an electrical to a chemical signal; they directly demonstrate that the enzyme activity of Ci-VSP changes in a voltage-dependent manner through the operation of the voltage sensor. Prior to this work, it was unclear which phosphoinositides were the major substrates of the phosphatase activity, and whether depolarisation or hyperpolarisation induced the phosphatase activity. By expressing phosphoinositide-specific sensors in Xenopus oocytes and applying both electrophysiology and imaging of phosphoinositides, it was shown that enzyme activity is activated upon depolarisation (not upon hyperpolarisation), and that levels of both PtdIns(4,5)P2 and PtsIns(3,4,5)P3 are regulated by the operation of voltage sensor.

Our findings identify common principles of the voltage sensor shared between voltage-gated ion channels and the voltage-sensing phosphatase," comment the authors. "There is no question that the VSP is a much simpler model than ion channels for understanding the mechanisms of voltage sensing, and understanding the VSP will provide insights into the function of ion channels as well. Such knowledge is critical for understanding general mechanisms of voltage sensing and many disorders coupled with altered membrane excitabilities. The VSPs ability to tune phosphoinositide phosphatase activity by voltage will also serve as an important molecular tool to understand mechanisms of tumor suppressor phosphatase, PTEN, and other phosphatases that underlie carcinogenesis and metabolic disorders."


'/>"/>

Contact: Melanie Thomson
melanie.thomson@oxon.blackwellpublishing.com
44-018-654-76270
Blackwell Publishing Ltd.
Source:Eurekalert

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. New insight into people who see colors in letters and numbers
3. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
4. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
5. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
6. New insight into regulation of blood stem cells
7. Insight into DNAs weakest links may yield clues to cancer biology
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. New insights into how Huntingtons disease attacks the brain
10. Gambling monkeys give insight into neural machinery of risk
11. Structures of marine toxins provide insight into their effectiveness as cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2016)... 2016 Einzigartige ... und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler Kommunikationsdienste, ... SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie einzusetzen. ... Möglichkeit angeboten, im Rahmen mobiler Apps neben ...
(Date:3/22/2016)... OTTAWA, Ontario , PROVO ... 2016 Newborn Screening Ontario (NSO), which operates ... for molecular testing, and Tute Genomics and ... process management technology respectively, today announced the launch of ... new next-generation sequencing (NGS) testing panel. ...
(Date:3/18/2016)... --> --> Competitive Landscape Analysis ... Physical infrastructure and Perimeter Surveillance & Detection Systems ... and the continuing migration crisis in the Middle ... led visiongain to publish this unique report, which is crucial ... & security companies in the border security market and the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample ... the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest features ... will also be presenting a scientific poster on Disrupting Clinical Trials in The ...
(Date:6/23/2016)... FRANCISCO , June 22, 2016  Amgen (NASDAQ: ... sponsorship of the QB3@953 life sciences incubator ... human health. The shared laboratory space at QB3@953 was ... overcome a key obstacle for many early stage organizations ... part of the sponsorship, Amgen launched two "Amgen Golden ...
Breaking Biology Technology: