Navigation Links
New insight into the mechanisms of voltage sensing and transduction in biological processes
Date:9/14/2007

The voltage sensor of voltage-gated ion channels is a conserved protein domain that senses millivolt changes in transmembrane potential, to regulate ion permeation through the channel. A recently discovered protein, Ci-VSP, has a voltage sensor that is coupled not to an ion channel but to a phosphatidylinositide phosphosphatase, the activity of which depends on membrane potential.

In a new paper published in The Journal of Physiology, Murata and Okamura, from the Okazaki Institute for Integrative Bioscience, examine a voltage-sensitive phosphatase that converts an electrical to a chemical signal; they directly demonstrate that the enzyme activity of Ci-VSP changes in a voltage-dependent manner through the operation of the voltage sensor. Prior to this work, it was unclear which phosphoinositides were the major substrates of the phosphatase activity, and whether depolarisation or hyperpolarisation induced the phosphatase activity. By expressing phosphoinositide-specific sensors in Xenopus oocytes and applying both electrophysiology and imaging of phosphoinositides, it was shown that enzyme activity is activated upon depolarisation (not upon hyperpolarisation), and that levels of both PtdIns(4,5)P2 and PtsIns(3,4,5)P3 are regulated by the operation of voltage sensor.

Our findings identify common principles of the voltage sensor shared between voltage-gated ion channels and the voltage-sensing phosphatase," comment the authors. "There is no question that the VSP is a much simpler model than ion channels for understanding the mechanisms of voltage sensing, and understanding the VSP will provide insights into the function of ion channels as well. Such knowledge is critical for understanding general mechanisms of voltage sensing and many disorders coupled with altered membrane excitabilities. The VSPs ability to tune phosphoinositide phosphatase activity by voltage will also serve as an important molecular tool to understand mechanisms of tumor suppressor phosphatase, PTEN, and other phosphatases that underlie carcinogenesis and metabolic disorders."


'/>"/>

Contact: Melanie Thomson
melanie.thomson@oxon.blackwellpublishing.com
44-018-654-76270
Blackwell Publishing Ltd.
Source:Eurekalert

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. New insight into people who see colors in letters and numbers
3. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
4. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
5. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
6. New insight into regulation of blood stem cells
7. Insight into DNAs weakest links may yield clues to cancer biology
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. New insights into how Huntingtons disease attacks the brain
10. Gambling monkeys give insight into neural machinery of risk
11. Structures of marine toxins provide insight into their effectiveness as cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... March 15, 2016 --> ... by Transparency Market Research "Digital Door Lock Systems Market - ... - 2023," the global digital door lock systems market in ... 2014 and is forecast to grow at a CAGR of ... small and medium enterprises (MSMEs) across the world and high ...
(Date:3/14/2016)... , March 14, 2016 NXTD ... growing mobile commerce market, announces the airing of a new ... starting the week of March 21 st .  The commercials ... including its popular Squawk on the Street show. --> ... on the growing mobile commerce market, announces the airing of ...
(Date:3/11/2016)... 11, 2016 http://www.apimages.com ) - --> ... is available at AP Images ( http://www.apimages.com ) - ... used to produce the new refugee identity cards. DERMALOG will be ... CeBIT in Hanover next week.   --> ... be used to produce the new refugee identity cards. DERMALOG will ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... , ... May 25, 2016 , ... ... a Thai delegation at BIO 2016 in San Francisco. Located at booth number ... be available to answer questions and discuss the Thai biotechnology and life sciences ...
(Date:5/25/2016)... ... May 25, 2016 , ... The ... by the Office of the National Coordinator for Health IT (ONC) outlining a ... clinically relevant data were available when and where it was needed. The organization ...
(Date:5/25/2016)... ... 2016 , ... Lady had been battling arthritis since the age of two ... knee. Lady’s owner Hannah sought the help of Dr Jeff Christiansen of Superior ... cruciate ligament and help with the pain of Lady’s arthritis. Dr Christiansen suggested that ...
(Date:5/24/2016)...   MedyMatch Technology Ltd ., the data analytics healthcare ... support tools in the emergency room, announced today that it ... Technology Industries (IATI) BioMed Conference. The Conference ... National Life Sciences and Technology Week, and is being held ... Tel Aviv, Israel . Gene Saragnese ...
Breaking Biology Technology: