Navigation Links
New insight into mechanisms behind autoimmune diseases suggests a potential therapy
Date:3/18/2012

LA JOLLA, Calif., March 18, 2012 Autoimmune diseases, such as Type I diabetes and rheumatoid arthritis, are caused by an immune system gone haywire, where the body's defense system assaults and destroys healthy tissues. A mutant form of a protein called LYP has been implicated in multiple autoimmune diseases, but the precise molecular pathway involved has been unknown. Now, in a paper published March 18 in Nature Chemical Biology, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) show how the errant form of LYP can disrupt the immune system. In doing so, they also found a potential new therapy for autoimmune diseasesa chemical compound that appears to inhibit this mutant protein.

T cells and autoimmune disease

In Caucasian populations, a mutated form of LYP (short for lymphoid tyrosine phosphatase) is the third most common single-gene cause of Type 1 diabetes. It ranks second for rheumatoid arthritis.

Researchers have known that LYP and another protein called CSK (C-terminal Src kinase) work cooperatively to keep the immune system's destructive T cells from being activated. Because the uncontrolled activation of T cells is a hallmark of many autoimmune diseases, the proper functioning of LYP with CSK is thought to keep T cells in check.

While the normal form of LYP can bind CSK, the disease-associated mutant LYP cannot. In the new study, Sanford-Burnham researcher Lutz Tautz, Ph.D. led an international group of scientists in showing that normal LYP can disassociate itself from CSK, which paradoxically makes LYP better at dampening the signals that activate T cells. These findings explain why the mutant form of LYP is better at limiting T cell activation than normal LYP.

"It's still a mystery how a protein that impairs T cell signaling causes autoimmunity," said Tautz. "In a simple model of autoimmunity, you would think the opposite."

One possible explanatio
'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
2. New insights into cloud formation
3. Notre Dame researchers are providing insights into elephant behavior and conservation issues
4. Research offers insight to how fructose causes obesity and other illness
5. Prolific plant hunters provide insight in strategy for collecting undiscovered plant species
6. Metadynamics technique offers insight into mineral growth and dissolution
7. Ecologists gain insight into the likely consequences of global warming
8. New insights into how the brain reconstructs the third dimension
9. New insights come from tracing cells that irreversibly scar lungs
10. Huskies lend insight into mercury risk
11. Genomic sequence and comparison of 2 macaques reveal new insights into biomedical research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insight into mechanisms behind autoimmune diseases suggests a potential therapy
(Date:5/17/2013)... Shenzhen, China---- Why Tibetan antelope can live at ... a collaborative research published in Nature Communications ... institutes provide evidence that some genetic factors may ... highland environments. The data in this work will ... and the biology of other ruminant species. , ...
(Date:5/17/2013)... American Societies for Experimental Biology (FASEB) released a new ... funding trends highlighting the devastating impact of sequestration on ... analysis follows a May 15th Senate Appropriations Committee hearing ... that the $1.6 billion cut the agency sustained in ... impact on the scientific community." , According to ...
(Date:5/16/2013)... FASEB MARC (Maximizing Access to Research Careers) ... The Endocrine Society (ENDO) 95th Annual Meeting in ... awards are meant to promote the entry of ... the mainstream of the basic science community and ... the ENDO 2013 Annual Meeting. , Awards are ...
Breaking Biology News(10 mins):The genome sequence of Tibetan antelope sheds new light on high-altitude adaptation 2
... massive survey of genetic diversity in maize, also known as corn, ... should pave the way to significant improvements in a plant that ... around the world. The new map, a special type of ... recombination across the genome of 27 inbred lines of maize. The ...
... Ind. - Purdue University scientists have helped identify and group ... in maize, an effort that expands their ability to discover ... The Purdue scientists, led by Nicholas Carpita, a professor ... cell wall genes in the journal Plant Physiology ...
... Ill. A new statistical technique developed by researchers ... a genome for specific gene-regulatory regions without requiring prior ... been experimentally validated in both the mouse genome and ... more widely applicable than other approaches, and is especially ...
Cached Biology News:Maize cell wall genes identified, giving boost to biofuel research 2Technique finds gene regulatory sites without knowledge of regulators 2
(Date:5/17/2013)... Darrington, WA (PRWEB) May 17, 2013 Tooth ... 5th graders showing active signs of the disease. The World ... children and nearly 100% of adults have cavities. What are ... Research is showing a strong connection between the oral ... why is this disease so rampant, yet it is also ...
(Date:5/16/2013)... (PRWEB) May 16, 2013 Oven Industries, ... temperature controllers and temperature sensors since 1964. ... used in industrial control system applications. As ... device includes a generic, control loop feedback system, which ... expertly used to adjust a systematic process, using a ...
(Date:5/16/2013)... 2013 Cambridge Healthtech Institute will host ... 2013 at the Renaissance Waterfront Hotel in Boston, MA. ... close-up look at the current strategies and innovations for ... Leaders in the field will reveal how their ... with greater specificity and efficiency. , “In this age ...
(Date:5/16/2013)... -- The registration deadline has been extended until May 22 ... Conference, the premier conference for bioscience financial officers. The ... San Diego Bayfront. "We are putting ... to make sure as many people as possible have ... , Chief Financial Officer of Mast Therapeutics, Inc. ...
Breaking Biology Technology:Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 2Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 3New PID Temperature Controllers Announced by Oven Industries Inc. 2The 2013 Bioprocessing Summit to Bring Together International Leaders to Discuss Today's Bioprocess Issues From Cell Line Selection to Manufacturing in Boston, MA 2Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 2Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 3Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 4
... has exciting new and unique products; ... announced in near future ..., BOCA RATON, Fla., May 2 ... their stock is now,up and trading on the Pink Sheets. The ... PinkSheets.com. From this point,Solei will continue on toward becoming a fully ...
... PHILADELPHIA, May 2 eResearchTechnology, Inc.,(eRT), (Nasdaq: ... centralized,electrocardiographic (ECG) collection and interpretation services,announced today ... President and,Chief Executive Officer, and Richard Baron, ... present at the Deutsche Bank 33rd Annual,Healthcare ...
... VRE and other multi-resistant organisms, PRINCETON, N.J., ... a provider of advanced wound care products, today,announced ... annual review of top wound,care studies, devoted a ... Leptospermum Honey. The article, "Spotlighting the Top-10,Research Findings ...
Cached Biology Technology:Solei Systems, Inc., Announces That the Company Is Now Publicly Traded 2Solei Systems, Inc., Announces That the Company Is Now Publicly Traded 3Solei Systems, Inc., Announces That the Company Is Now Publicly Traded 4eResearchTechnology to Present at the Deutsche Bank 33rd Annual Healthcare Conference on May 7th 2008 2Skin & Aging Article Finds Derma Sciences MEDIHONEY(TM) Helps to Promote Healing Where Antibiotics Fail 2Skin & Aging Article Finds Derma Sciences MEDIHONEY(TM) Helps to Promote Healing Where Antibiotics Fail 3Skin & Aging Article Finds Derma Sciences MEDIHONEY(TM) Helps to Promote Healing Where Antibiotics Fail 4