Navigation Links
New insight into double-protected dance of cell division
Date:3/5/2013

AMHERST, Mass. Biochemists at the University of Massachusetts Amherst including assistant professor Peter Chien recently gained new insight into how protein synthesis and degradation help to regulate the delicate ballet of cell division. In particular, they reveal how two proteins shelter each other in "mutually assured cleanup" to insure that division goes smoothly and safely.

Cells must routinely dispose of leftover proteins with the aid of proteases that cut up and recycle used proteins. The problem for biochemists is that the same protein molecule can be toxic garbage at one time, but essential for function at another time such as during the cell cycle, that is, events that unfold to achieve replication of chromosomes and division of the cell.

As Chien explains, "We know that a process that has to happen as reliably and stably as cell division also has to be flexible enough to allow the organism to grow and respond to its ever-changing environment. We're interested in uncovering all the steps and back-up safeguards that cells use to robustly protect replication while at the same time allowing other functions to proceed." Results appear in the early online edition of Molecular Microbiology.

To do this work, Amber Cantin in Chien's lab, closely collaborated with Michael Laub and colleagues at MIT to look in a bacteria, Caulobacter, where they had previously figured out how cells distinguish waste proteins from useful molecules. They focused on a protein called CtrA that sits on DNA like a cap, controlling replication until conditions are right for division to occur.

Destruction of CtrA allows cells to start replicating their chromosome. Cantin used biochemical experiments with highly purified proteins to show that CtrA was only degraded when it was bound to DNA and that another protein, SciP, could help make CtrA bind better to DNA, making CtrA more resistant to proteolysis.

Surprisingly, thi
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Misplaced molecules: New insights into the causes of dementia
2. Study provides insights into plant evolution
3. A microbial biorefinery provides new insight into how bacteria regulate genes
4. Life experiences put their stamp on the next generation: New insights from epigenetics
5. Random Forests Tree Ensembles: Salford Systems Exclusive Insight
6. Discovery of sexual mating in Candida albicans could provide insights into infections
7. UCSB research provides insight into mechanics of arthritis
8. New insights into the borderline personality brain
9. Study offers new insights into the mechanics of muscle fatigue
10. UNC research uncovers new insight into cell development and cancer
11. Gout study offers genetic insight into disease of kings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insight into double-protected dance of cell division
(Date:9/21/2014)... dioxide emissions, the main contributor to global warming, are set ... of 40 billion tonnes. , The 2.5 per cent projected ... Carbon Project, which is co-led in the UK by researchers ... University of East Anglia and the College of Engineering, Mathematics ... comes ahead of the New York Climate Summit, where world ...
(Date:9/21/2014)... developed a protein therapy that disrupts the process that ... sites, travel through the blood stream and start aggressive ... known as metastasis, can cause cancer to spread with ... succumb to cancer fall prey to metastatic forms of ... bioengineering who describes a new therapeutic approach in ...
(Date:9/19/2014)... the sake of fairness per se but in order ... Frans de Waal, PhD, and Sarah Brosnan, PhD, co-authors ... is defined as a negative reaction to unequal outcomes. ... , Their conclusion comes after the co-authors reviewed more ... it is the evolution of forestalling partner dissatisfaction with ...
Breaking Biology News(10 mins):CO2 emissions set to reach new 40 billion ton record high in 2014 2CO2 emissions set to reach new 40 billion ton record high in 2014 3Stanford researchers create 'evolved' protein that may stop cancer from spreading 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 3Stanford researchers create 'evolved' protein that may stop cancer from spreading 4Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3
... New research shows that nearly 1 in 5 cases of ... are caused by not one but multiple strains of the ... of Minnesota Medical School report their findings today in the ... journal published by the American Society for Microbiology. "Koch,s ...
... of researchers led by Jeffrey Peng, assistant professor of ... is using Nuclear Magnetic Resonance (NMR), to move drug ... drugs and their targets. The research, which was ... contributes to the growing attention given toward the shape-shifting ...
... Spanish . , Researchers at the Centre ... the Universidad de Kentucky (USA), have discovered a new way ... pathogen agents responsible for transmissible spongiform encephalopathies or TSEs) by ... control prion disease in deer, which has become an epidemic ...
Cached Biology News:Unexpectedly high rate of multiple strains in fungal infection 2Nuclear magnetic resonance aids in drug design 2Researchers embark on work to control the prion epidemic affecting deer in the USA 2Researchers embark on work to control the prion epidemic affecting deer in the USA 3
(Date:9/21/2014)... Chemical Sciences play a significant role ... air and safe water, healthy food, and dependable ... food scientists, educators, and scientists have a great ... of Chemistry for the national development, and to ... the fastest emerging Sciences, accelerating with a tremendous ...
(Date:9/19/2014)... simple. From crop yields to disease risks, the biological ... "complex traits." Just as for heightthe textbook example of ... disease are shaped by multiple genetic and environmental influences, ... track down such genes, geneticists typically mate two individuals ... and a small mouseand then study their descendents, looking ...
(Date:9/19/2014)... SPRINGS, Florida , September 19, 2014 ... in medical technology, development of emerging drug systems and ... PBIO), Benton, Dickinson and Company (NYSE: BDX ... ), Regado Biosciences Inc. (NASDAQ: RGDO ), ... Hologic Inc. (NASDAQ: HOLX) Pressure BioSciences, Inc. ...
(Date:9/19/2014)... Minnesota (PRWEB) September 19, 2014 ... related food industries will gather October 5–8, 2014, ... the Rhode Island Convention Center in Providence, Rhode ... feature the work of food scientists, chemists, microbiologists, ... control, and food production management. To date, 1,000 ...
Breaking Biology Technology:Chemistry for Global Development during the Open Access Week 2Chemistry for Global Development during the Open Access Week 3Want to link genes to complex traits? Start with more diversity 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 5Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 6Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 7Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3
... ST. JOSEPH, Mich., March 24 GeneGo, Inc., the ... NIHR Biomedical Research Centre for Mental Health at the ... College London (BRC-MH), has joined the MetaMiner CNS Partnership ... Breen are leading the BRC-MH team for this project. ...
... adipocyte differentiation kits -SAN DIEGO and NEW HAVEN, ... co-exclusive license to market CellDesign,s AdipoDesign Starter Kit ... and study adipocytes from adipogenic progenitor cells. ... of leading stem cell research technologies and enables ...
... an era , Some 65 million years ago, ... more catastrophic events - such as a comet strike or ... dust and smoke that obstructed sunlight for a long period ... the plant species and numerous animals, including the dinosaurs. Only ...
Cached Biology Technology:The NIHR Biomedical Research Centre for Mental Health London has Joined the MetaMiner CNS Partnership Program 2The NIHR Biomedical Research Centre for Mental Health London has Joined the MetaMiner CNS Partnership Program 3The NIHR Biomedical Research Centre for Mental Health London has Joined the MetaMiner CNS Partnership Program 4Stemgent, CellDesign Sign Co-Exclusive Marketing Agreement on Stem Cell-Based Adipocyte Research Products 2DNA duplication: A mechanism for 'survival of the fittest' 2
CHIMAERIC HUMAN IgA2 ANTI NP...
... For use with suspension ... RiboCap™ uses vacuum filtration or ... culture media. Compatible with ... available in larger package sizes ...
nuclear cap binding protein subunit 1, 80kDa, mRNA...
... The Captivate magnetic ... can be used in conjunction ... (C-21473, C-21474, C-21476) or other ... with most 96-well microplates. Cell ...
Biology Products: