Navigation Links
New insight into double-protected dance of cell division
Date:3/5/2013

AMHERST, Mass. Biochemists at the University of Massachusetts Amherst including assistant professor Peter Chien recently gained new insight into how protein synthesis and degradation help to regulate the delicate ballet of cell division. In particular, they reveal how two proteins shelter each other in "mutually assured cleanup" to insure that division goes smoothly and safely.

Cells must routinely dispose of leftover proteins with the aid of proteases that cut up and recycle used proteins. The problem for biochemists is that the same protein molecule can be toxic garbage at one time, but essential for function at another time such as during the cell cycle, that is, events that unfold to achieve replication of chromosomes and division of the cell.

As Chien explains, "We know that a process that has to happen as reliably and stably as cell division also has to be flexible enough to allow the organism to grow and respond to its ever-changing environment. We're interested in uncovering all the steps and back-up safeguards that cells use to robustly protect replication while at the same time allowing other functions to proceed." Results appear in the early online edition of Molecular Microbiology.

To do this work, Amber Cantin in Chien's lab, closely collaborated with Michael Laub and colleagues at MIT to look in a bacteria, Caulobacter, where they had previously figured out how cells distinguish waste proteins from useful molecules. They focused on a protein called CtrA that sits on DNA like a cap, controlling replication until conditions are right for division to occur.

Destruction of CtrA allows cells to start replicating their chromosome. Cantin used biochemical experiments with highly purified proteins to show that CtrA was only degraded when it was bound to DNA and that another protein, SciP, could help make CtrA bind better to DNA, making CtrA more resistant to proteolysis.

Surprisingly, this also made SciP less able to be destroyed as well, showing that both proteins prevent their own destruction by protecting each other. In addition, while both proteins were destroyed, they were recognized by completely different proteases. These advances, along with current findings, may offer medical researchers a clue for understanding diseases such as abnormal cell cycle progression in cancer.


'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Related biology news :

1. Misplaced molecules: New insights into the causes of dementia
2. Study provides insights into plant evolution
3. A microbial biorefinery provides new insight into how bacteria regulate genes
4. Life experiences put their stamp on the next generation: New insights from epigenetics
5. Random Forests Tree Ensembles: Salford Systems Exclusive Insight
6. Discovery of sexual mating in Candida albicans could provide insights into infections
7. UCSB research provides insight into mechanics of arthritis
8. New insights into the borderline personality brain
9. Study offers new insights into the mechanics of muscle fatigue
10. UNC research uncovers new insight into cell development and cancer
11. Gout study offers genetic insight into disease of kings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New insight into double-protected dance of cell division
(Date:4/13/2016)... 13, 2016  IMPOWER physicians supporting Medicaid patients in ... new clinical standard in telehealth thanks to a new ... higi platform, IMPOWER patients can routinely track key health ... mass index, and, when they opt in, share them ... to a local retail location at no cost. By ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
(Date:3/22/2016)... and SANDY, Utah , ... which operates the highest sample volume laboratory in ... Genomics and UNIConnect, leaders in clinical sequencing informatics and ... launch of a project to establish the informatics infrastructure ... NSO has been contracted by the Ontario ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published ... how a patient who developed lymphedema after being treated for breast cancer benefitted from ... the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... 23, 2016 Andrew ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... journal from touchONCOLOGY, Andrew D Zelenetz , ... cancer care is placing an increasing burden on ... biologic therapies. With the patents on many biologics ...
(Date:6/23/2016)... Prairie, WI (PRWEB) , ... June 23, 2016 ... ... consultancy focused on quality, regulatory and technical consulting, provides a free webinar ... is presented on July 13, 2016 at 12pm CT at no charge. , ...
Breaking Biology Technology: