Navigation Links
New insight into Alzheimer's disease pathology
Date:5/4/2009

An Alzheimer's-related protein helps form and maintain nerve cell connections, according to a study published in the May 4 print issue of the Journal of Cell Biology and online at www.jcb.org.

The protein, called presenilin, is mutated in many cases of inherited Alzheimer's disease. Although the inherited form of Alzheimer's is relatively rare, researchers hope that by studying the function of the protein, they will glean insights into the pathology of the more common non-inherited form of the disease. Presenilin is known to form part of an enzyme complex called gamma secretase, which sits in nerve cell membranes and chops up other proteins. Inoue et al have found a new target of gamma secretase, a protein called EphA4.

The product of EphA4 cleavage drove the formation and maintenance of dendritic spines the nerve cell's receivers for transmitted signals. These results fit with a growing hypothesis that failing nerve transmission might be an early step in the pathology of Alzheimer's.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Limping rat provides sciatica insights
2. First neuroimaging study examining motor execution in children with autism reveals new insights
3. New insights into progressive hearing loss
4. Lohafex provides new insights on plankton ecology
5. Addiction: Insights from Parkinsons disease
6. European satellites provide new insight into ozone-depleting species
7. Mixed population provides insights into human genetic makeup
8. New paper offers key insights into how new species emerge
9. New insights into a leading poultry disease and its risks to human health
10. New insight into how bees see
11. Mixing genomics and geography yields insights into life and environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... diner ripping open a dinner roll, a fuel cell ... a hydrogen molecule. Now researchers have captured a view ... of its hydrogen feast. The view confirms previous hypotheses ... work better for alternative energy uses. , This study ... the hydrogen halves end up in the structure of ...
(Date:4/23/2014)... French and Spanish . ... the CEC released its Conservation Assessment for the Big ... which identifies 29 priority conservation areas in a region ... protected areas in the states of Texas, Coahuila, and ... semi-arid habitats inhabited by rare and endangered plants and ...
(Date:4/23/2014)... A team of researchers in Korea who ... brains of nonhuman primates and assessed cell survival ... that the hNSCs had differentiated into neurons at ... The study will be published in a future ... currently freely available on-line as an unedited early ...
Breaking Biology News(10 mins):Halving hydrogen 2Halving hydrogen 3Halving hydrogen 4Conservation priorities released for several protected areas along US-Mexico border 2Conservation priorities released for several protected areas along US-Mexico border 3Study finds long-term survival of human neural stem cells transplanted into primate brain 2
... Virginia Commonwealth University immunologists studying mast cells, known to ... have identified a hormone-like molecule that can kill these ... mice. , The findings move researchers another step ... and may help researchers develop new treatments for allergy ...
... day, tens of thousands of biologists around the globe ... online algorithm called BLAST ?typically submitting 200 to 400 ... matched against the billions of letters for known genes. ... or evolutionary relationships, scientists routinely use BLAST to churn ...
... captures pictures beneath the living brain's surfaceResearchers at Stanford ... that can capture micron-scale images from deep in the ... combines a pair of powerful optical and mechanical techniques ... the hand. The results appear in the September 1, ...
Cached Biology News:VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease 2Drawing with DNA: 'Bioart' illuminates genomics 2Drawing with DNA: 'Bioart' illuminates genomics 3Microscopic brain imaging in the palm of your hand 2Microscopic brain imaging in the palm of your hand 3
(Date:1/15/2014)... ­ RedBrick Health , a fast-growing leader in ... that EmblemHealth , the New York ... providing the RedBrick Compass health assessment, combined with the ... its members. EmblemHealth is among the first health plans ...
(Date:1/15/2014)... A study has been launched to test whether technology ... help to tackle the problem of obesity.  This unique healthcare ... based in Stowmarket) and academics at University Campus Suffolk is ... which is inspired by equipment used to collect data about ...
(Date:1/15/2014)... 15, 2014 Two champions of science, ... sponsorship of an annual competition for middle and high ... to, innovative STEM study. The competition presents students with ... of Engineering Aptitude, Mathematics, and Sciences is a ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to ... Science organizations who need document translations. Clients will now ... documents in advance with a selection of nearly 50 life ... a critical factor in clinical and scientific fields, and decrease ...
Breaking Biology Technology:EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5DTS Improves Efficiency for Life Science Document Translations 2
... , PITTSBURGH, Sept. 23 ... first thing the international visitors notice are clear skies and ... the city,s three rivers. Instead, they are greeted by ... transformed itself from a manufacturing economy to a service economy ...
... , CARLSBAD, Calif., Sept. 23 MO BIO ... purification, announces the launch of an innovative new product, PowerWater(R) RNA ... of filtered water samples. PowerWater(R) RNA Isolation Kit is expected ... safety testing, microbial community analysis and metagenomics. , ...
... , BOSTON, Sept. 23 ... PRXL ) and a leading global life sciences consultancy ... second annual study on the state of the U.S. Food ... analysis, contained in the new white paper entitled "The ...
Cached Biology Technology:Pittsburgh Life Sciences Greenhouse Demonstrates a Region's Economic Resilience 2Pittsburgh Life Sciences Greenhouse Demonstrates a Region's Economic Resilience 3MO BIO Laboratories, Inc. Launches PowerWater(R) RNA Isolation Kit 2PAREXEL Consulting Releases New Study Data on Drug Development Timelines in Safety First Era 2PAREXEL Consulting Releases New Study Data on Drug Development Timelines in Safety First Era 3PAREXEL Consulting Releases New Study Data on Drug Development Timelines in Safety First Era 4PAREXEL Consulting Releases New Study Data on Drug Development Timelines in Safety First Era 5
Sf21 Insect Cells (Frozen) in Max-XP Medium...
Lyophilized solid. Suitable for evaluating functional activity of human complement components and for other research requiring a high level of hemolytic activity. ...
... been developed for affinity capture of ... of ProteinChip chemical surfaces allow differential ... unique biochemical properties. Each chip has ... comparison, and the chips are color-coded ...
... been developed for affinity capture of ... of ProteinChip chemical surfaces allow differential ... unique biochemical properties. Each chip has ... comparison, and the chips are color-coded ...
Biology Products: