Navigation Links
New insight into Alzheimer's disease pathology
Date:5/4/2009

An Alzheimer's-related protein helps form and maintain nerve cell connections, according to a study published in the May 4 print issue of the Journal of Cell Biology and online at www.jcb.org.

The protein, called presenilin, is mutated in many cases of inherited Alzheimer's disease. Although the inherited form of Alzheimer's is relatively rare, researchers hope that by studying the function of the protein, they will glean insights into the pathology of the more common non-inherited form of the disease. Presenilin is known to form part of an enzyme complex called gamma secretase, which sits in nerve cell membranes and chops up other proteins. Inoue et al have found a new target of gamma secretase, a protein called EphA4.

The product of EphA4 cleavage drove the formation and maintenance of dendritic spines the nerve cell's receivers for transmitted signals. These results fit with a growing hypothesis that failing nerve transmission might be an early step in the pathology of Alzheimer's.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Limping rat provides sciatica insights
2. First neuroimaging study examining motor execution in children with autism reveals new insights
3. New insights into progressive hearing loss
4. Lohafex provides new insights on plankton ecology
5. Addiction: Insights from Parkinsons disease
6. European satellites provide new insight into ozone-depleting species
7. Mixed population provides insights into human genetic makeup
8. New paper offers key insights into how new species emerge
9. New insights into a leading poultry disease and its risks to human health
10. New insight into how bees see
11. Mixing genomics and geography yields insights into life and environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... New York , March 15, 2016 ... new market report published by Transparency Market Research "Digital Door ... Trends and Forecast 2015 - 2023," the global digital door ... US$ 731.9 Mn in 2014 and is forecast to grow ... 2023. Growth of micro, small and medium enterprises (MSMEs) across ...
(Date:3/14/2016)... -- NXTD ) ("NXT-ID" or the "Company"), a ... airing of a new series of commercials on Time Warner ... st .  The commercials will air on Bloomberg TV, Fox ... Street show. --> NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ...
(Date:3/11/2016)... HANOVER, Germany , March 11, 2016 ... - Cross reference: Picture is available at AP Images ( ... scanner from DERMALOG will be used to produce the new refugee ... of other biometric innovations, at CeBIT in Hanover ... LF10 scanner from DERMALOG will be used to produce the new ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... , ... May 26, 2016 , ... ... company, today announced several positive developments that position the Company for the future. ... of the transaction, Craig F. Kinghorn has been appointed Chairman of the Board, ...
(Date:5/25/2016)... ... May 25, 2016 , ... Founder of the Fitzmaurice ... surgery and surgery of the hand by the National Board of Physicians and ... above and beyond in his pursuit of providing the most comprehensive, effective treatment ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... U.S. Food and Drug Administration (FDA) has granted the company’s orphan drug designation ... company’s second orphan drug designation granted by the FDA. , Spinocerebellar ataxia ...
(Date:5/23/2016)... , ... May 23, 2016 , ... The need for blood donations in South Texas ... by the South Texas Blood & Tissue Center, blood donations are on the decline. In ... and they are down 21 percent in South Texas in the last four years alone. ...
Breaking Biology Technology: