Navigation Links
New insight into Alzheimer's disease pathology
Date:5/4/2009

An Alzheimer's-related protein helps form and maintain nerve cell connections, according to a study published in the May 4 print issue of the Journal of Cell Biology and online at www.jcb.org.

The protein, called presenilin, is mutated in many cases of inherited Alzheimer's disease. Although the inherited form of Alzheimer's is relatively rare, researchers hope that by studying the function of the protein, they will glean insights into the pathology of the more common non-inherited form of the disease. Presenilin is known to form part of an enzyme complex called gamma secretase, which sits in nerve cell membranes and chops up other proteins. Inoue et al have found a new target of gamma secretase, a protein called EphA4.

The product of EphA4 cleavage drove the formation and maintenance of dendritic spines the nerve cell's receivers for transmitted signals. These results fit with a growing hypothesis that failing nerve transmission might be an early step in the pathology of Alzheimer's.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Limping rat provides sciatica insights
2. First neuroimaging study examining motor execution in children with autism reveals new insights
3. New insights into progressive hearing loss
4. Lohafex provides new insights on plankton ecology
5. Addiction: Insights from Parkinsons disease
6. European satellites provide new insight into ozone-depleting species
7. Mixed population provides insights into human genetic makeup
8. New paper offers key insights into how new species emerge
9. New insights into a leading poultry disease and its risks to human health
10. New insight into how bees see
11. Mixing genomics and geography yields insights into life and environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... Research and Markets has announced the addition of the ... report to their offering. ... The biometric vehicle access system market, in terms ... from 2016 to 2021. The market is estimated to be USD ... by 2021. The growth of the biometric vehicle access system market ...
(Date:12/15/2016)... Canada and BADEN-BADEN, Germany , ... a leading global financial services provider, today announced an agreement ... passive behavioural biometrics, to join forces. The partnership will enable ... mitigation strategies in compliance with local data protection regulation. ... In order ...
(Date:12/15/2016)... ... announced the addition of the "Global Military Biometrics Market 2016-2020" ... military biometrics market to grow at a CAGR of 7.5% during the ... an in-depth market analysis with inputs from industry experts. The report covers ... report also includes a discussion of the key vendors operating in this ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... , January 20, 2017 ... cancer is one of leading causes of death worldwide. ... Although the number of cancer related deaths increased gradually ... Rising in incidence rate of various cancers continues to ... a research report by Global Market Insights, Inc. cancer ...
(Date:1/19/2017)... Research and Markets has announced the addition of the "Cancer ... Opportunity Analysis and Industry Forecast, 2014-2022" report to their offering. ... Cancer Biomarkers ... $15,737 million by 2022 from $6,521 in 2015, growing at a ... technologies segment accounted for more than half of the revenue share ...
(Date:1/19/2017)... and HOUSTON , Jan. 19, ... today announced the formation of its Medical/Clinical Advisory ... and industry veterans who enhance the range and ... accelerates development of its novel prenatal diagnostic tests.  ... clinical and strategic guidance for the company,s product ...
(Date:1/19/2017)... Research and Markets ... has announced the addition of the "Implantable Biomaterials ... report to their offering. Report Highlights: ... detailed analysis on current and future market trends to identify the investment ... as the base numbers Key market trends across the ...
Breaking Biology Technology: