Navigation Links
New inhibitors of elusive enzymes promise to be valuable scientific tools
Date:10/31/2012

LA JOLLA, CA October 31, 2012 Scientists at The Scripps Research Institute (TSRI) have discovered the first selective inhibitors of an important set of enzymes. The new inhibitors, and chemical probes based on them, now can be used to study the functions of enzymes known as diacylglycerol lipases (DAGL), their products, and the pathways they regulate. Early tests in mouse macrophages suggest that DAGL-inhibiting compounds might also have therapeutic uses, for they suppress the production of a pro-inflammatory molecule that has been implicated in rheumatoid arthritis and related conditions.

"We've developed the first set of chemical probes that effectively allows one to study these DAGL enzymes in living cell and animal models," said Benjamin F. Cravatt, chairman of the Department of Chemical Physiology, professor in the Dorris Neuroscience Center and member of the Skaggs Institute for Chemical Biology at TSRI. Cravatt and his laboratory conducted the new study, published in the current issue of the journal Nature Chemical Biology.

Important But Poorly Understood

DAGL enzymes have been of interest mainly because of their role in making 2-AG (2-Arachidonoylglycerol), an important cannabinoid that is naturally produced in humans and other mammals. Cannabinoids are named for Cannabis (marijuana) plants, because they stimulate the same cellular receptors that are hit by marijuana's active ingredients. Drugs that can enhance 2-AG's signaling in the nervous system are being developed as treatments for pain, depression and anxiety.

But 2-AG exists in various tissues throughout the body, and on the whole, its functions are not well understood. Until now researchers have lacked enzyme inhibitors that can usefully probe those functions by selectively shutting off 2-AG's production. "Existing DAGL inhibitors block many other enzymes, are not very potent, and do a poor job of getting into cells," Cravatt said. "There h
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study identifies pathway to enhance usefulness of EGFR inhibitors in lung cancer treatment
2. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
3. Infection biology: The elusive third factor
4. New screening technique yields elusive compounds to block immune-regulating enzyme
5. Computer simulations help explain why HIV cure remains elusive
6. Ancient enzymes function like nanopistons to unwind RNA
7. Is it a rock, or is it Jell-O? Defining the architecture of rhomboid enzymes
8. ORNL process improves catalytic rate of enzymes by 3,000 percent
9. An exoskeleton of advanced design promises a new degree of independence for people with paraplegia
10. Laser-powered needle promises pain-free injections
11. Realizing the promise of RNA nanotechnology for new drug development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New inhibitors of elusive enzymes promise to be valuable scientific tools
(Date:12/3/2014)... GLENDALE, Ariz. , Dec. 2, 2014 ... biometric hand readers, Inception Technologies is pleased to announce ... it easier for customers to collect the workforce data ... the problems that have been left by existing readers. ... to user interface, connectivity and modern technology. Older models ...
(Date:11/21/2014)... Nov. 20, 2014 Strict laws against distracted ... piloting the North American and European automotive sector towards ... gesture recognition systems that are intuitive and able to ... the industry. New analysis from Frost ... Market in Europe and ...
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
Breaking Biology News(10 mins):Inception Technologies to Release New Biometric Reader 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... Standard Reference Material (SRM) from the National Institute of ... more accurately diagnose and treat cytomegalovirus (CMV), a common ... with weakened immune systems. CMV is found in ... a member of the herpes family of viruses that ...
... A review article by researchers at Boston University ... hypertension, or high blood pressure, is the result of ... pressure on the arteries. Published online in the ... salt stimulates the sympathetic nervous system to produce adrenalin, ...
... Of all the habitable parts of our planet, one ecosystem ... ocean crust. This rocky realm of hard volcanic lava ... much of the world,s oceans. While scientists have estimated ... much as one-third of Earth,s total biomass, the habitable portion ...
Cached Biology News:NIST standard available for better diagnosis, treatment of cytomegalovirus 2Boston University School of Medicine researchers clarify link between salt and hypertension 2Scientists look to microbes to unlock Earth's deep secrets 2
(Date:12/19/2014)... BioPlus Specialty Pharmacy ... has an expanded team of Regional Pharmaceutical Care ... prescriber offices in their regions, with specific areas ... a variety of Regional Pharmaceutical Care Liaisons specializing ... hepatitis C help prescribers understand all the new ...
(Date:12/19/2014)... 2014 Reports from CDC ... suffer from one or more chronic health conditions - ... can address some of these diseases, but may not ... sufferers face. While implanted nerve stimulation devices today offer ... nerve, which can induce side effects. , To ...
(Date:12/19/2014)... 2014 With only 2 weeks left ... on Sartorius Biohit products . The product specials include ... Electronic Pipette Trade-in Program, and free pipette tips. , ... around the world. They are ideal for lab technicians ... ,     Full volume range of 0.1 uL ...
(Date:12/19/2014)... , Dec. 18, 2014 Relmada Therapeutics, ... for the treatment of chronic pain, announced the results ... "This was a transformational year in Relmada,s ... future for our company," said Sergio Traversa , ... we have executed on key financial, human resource and ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2
... seems to defy gravity as it hovers with feathered ... the 2008 Olympus BioScapes Digital Imaging Competition, the world,s ... life science subjects. Mr. M. I. “Spike” Walker of ... of what is called a fairy fly, actually a ...
... a defense against the Black Plague, a disease that wiped ... and which government agencies perceive as a terrorist threat today. ... developed a vaccine that early research shows is highly effective ... and USDA funded research appear in the August edition of ...
... Ind. - Fingerprints can reveal critical evidence, as well ... technology developed at Purdue University that detects trace amounts ... the prints. , The new technology also can distinguish ... difficult task for current optical forensic methods. , A ...
Cached Biology Technology: It's a Bug's Life, as Flawless Photo of Wasp Wins Worldwide Olympus BioScapes Competition : Winning Sure Doesn't Sting - Olympus BioScapes 2008 Competition 2 It's a Bug's Life, as Flawless Photo of Wasp Wins Worldwide Olympus BioScapes Competition : Winning Sure Doesn't Sting - Olympus BioScapes 2008 Competition 3 It's a Bug's Life, as Flawless Photo of Wasp Wins Worldwide Olympus BioScapes Competition : Winning Sure Doesn't Sting - Olympus BioScapes 2008 Competition 4UCF professor develops vaccine to protect against black plague bioterror attack 2UCF professor develops vaccine to protect against black plague bioterror attack 3Fingerprints provide clues to more than just identity 2
... Recognizes K+ Cl- Cotransporter-1 ... no significant sequence homology ... CCC.,SPECIES REACTIVITIES: The immunogen ... in human, mouse, porcine ...
...
Anti-G-alpha-i 1 G-Protein Host: mouse monoclonal Species Reactivity: human, mouse, rat Applications: WB Storage: 4C...
oligophrenin-1 (H-100)...
Biology Products: