Navigation Links
New inherited eye disease discovered
Date:12/11/2009

University of Iowa researchers have found the existence of a new, rare inherited retinal disease. Now the search is on to find the genetic cause, which investigators hope will increase understanding of more common retinal diseases.

The findings appeared in the Nov. 9 issue of the Archives of Ophthalmology.

The macula, located within the retina, is an area of high-resolution central vision that is needed to read or drive, for example. This area is damaged in more common retinal conditions such as macular degeneration and can be damaged by diabetes.

"It is rare to find a new inherited eye disease that affects the macula. We thought we had seen them all," said the study's lead author Vinit Mahajan, M.D., Ph.D., assistant professor of ophthalmology and visual sciences at the University of Iowa Roy J. and Lucille A. Carver College of Medicine.

"This newly found retinal disease causes abnormal blood vessels in the macula, and these vessels are prone to bleeding. This causes swelling or scars that 'black out' or blur parts of the field of vision," said Mahajan, who also is a retinal specialist with University of Iowa Hospitals and Clinics.

The finding came about when one person in a family in the United States sought care for eye problems. "If a doctor saw just one family member, they would probably call this macular degeneration. We knew there was something different, and we had to examine the rest of the family," Mahajan said.

The team assessed 20 extended family members who were not blind but had visual problems of different severities. Some family members also had areas of central vision loss, and some family members had strabismus, a disorder in which the eyes are not aligned.

The University of Iowa researchers have presented their findings at international meetings of retinal specialists in Arizona, Florida and London. The investigators are now working with researchers worldwide to determine if other people have this particular disease.

"Through our paper and by sharing pictures of what the affected eye looks like, we hope to find more people affected," Mahajan said. "We also will work to find the gene that causes the condition. This information could be very useful in eventually preventing or treating this and other diseases that affect the macula."

The advanced genetics research capabilities at the University of Iowa Carver Family Center for Macular Degeneration increase the likelihood of finding a gene, Mahajan said.


'/>"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-356-7127
University of Iowa
Source:Eurekalert  

Related biology news :

1. CU-Boulder worm study sheds light on human aging, inherited diseases
2. Mutation may cause inherited neuropathy
3. Multi-institutional study identifies new form of inherited risk of cancer
4. Inherited cancer mutation is widespread in America
5. Sibling study could lead to better treatments for inherited form of colon cancer
6. Inherited genetic cause, possible treatment found for complex lung disorder
7. CSHL scientists discover a new way in which epigenetic information is inherited
8. Researchers compile molecular manual for 100s of inherited diseases
9. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
10. Can happiness be inherited?
11. Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New inherited eye disease discovered
(Date:6/22/2016)... June 22, 2016   Acuant , ... verification solutions, has partnered with RightCrowd ® ... for Visitor Management, Self-Service Kiosks and Continuous ... that add functional enhancements to existing physical ... and venues with an automated ID verification ...
(Date:6/21/2016)... British Columbia , June 21, 2016 /PRNewswire/ ... appointed to the new role of principal product ... been named the director of customer development. Both ... NuData,s chief technical officer. The moves reflect NuData,s ... teams in response to high customer demand and ...
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... --  Ginkgo Bioworks , a leading organism design ... awarded as one of the World Economic Forum,s ... innovative companies. Ginkgo Bioworks is engineering biology to ... in the nutrition, health and consumer goods sectors. ... including Fortune 500 companies to design microbes for ...
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... to announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. ... years, is proud to add Target to its list of well-respected retailers. This ...
Breaking Biology Technology: