Navigation Links
New immune defense enzyme discovered
Date:4/3/2012

This release is available in German.

Neutrophil granulocytes comprise important defences for the immune system. When pathogenic bacteria penetrate the body, they are the first on the scene to mobilise other immune cells via signal molecules, thereby containing the risk. To this end, they release serine proteases enzymes that cut up other proteins to activate signal molecules. Scientists at the Max Planck Institute of Neurobiology in Martinsried have now discovered a new serine protease: neutrophil serine protease 4, or NSP4. This enzyme could provide a new target for the treatment of diseases that involve an overactive immune system, such as rheumatoid arthritis.

The functioning of the immune system is based on the complex interplay of the most diverse cells and mediators. For example, neutrophil granulocytes (a group of specialized white blood cells) react to bacteria by releasing substances called serine proteases. These enzymes are able to activate signal molecules, such as the chemokines, by cleaving them at a specific position on the molecule. The active signal molecules then guide other immune cells to the focus of inflammation in order to destroy the pathogens.

A research team led by Dieter Jenne at the Max Planck Institute of Neurobiology in Martinsried has come across a previously unknown protease in humans: neutrophil serine protease 4, or NSP4. "The special thing about this enzyme is that it cuts proteins that have the amino acid arginine at a particular point", says Dieter Jenne, research group leader at the Martinsried-based Institute. "This is where NSP4 differs from the other three known neutrophil serine proteases, which are similar in molecular structure, but have a different recognition motif." The scientists may be able to harness this difference to develop an active substance that specifically inhibits NSP4, there
'/>"/>

Contact: Dr. Dieter Jenne
djenne@neuro.mpg.de
49-898-578-3588
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Key to immune system disease could lie inside the cheek
2. Immune system implicated in prematurity complication
3. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
4. UCI-led study uncovers how Salmonella avoids the bodys immune response
5. U of Alberta researcher steps closer to understand autoimmune diseases
6. Depression could be evolutionary byproduct of immune system
7. Secrets of immune response illuminated in new study
8. Human immune cells react sensitively to stress
9. Stealthy leprosy pathogen evades critical vitamin D-dependent immune response
10. Aiding cancer therapy by mathematically modeling tumor-immune interactions
11. UCSF team uncovers how immune cells move against invaders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New immune defense enzyme discovered
(Date:4/22/2014)... As President Barack Obama begins a trip to ... strategic pivot to the Pacific, officials at the ... Asia-Pacific Technology and Education Partnership (APTEP) as an ... United States and its allies in the region. ... partnerships across the Asia-Pacific region, supports the development ...
(Date:4/22/2014)... news release is available in French . ... than a month, sequencing of the complete genome and ... Guinea forms a clade (variant) that is distinct from ... and in Gabon. Epidemiological investigations also linked the laboratory ... December 2013 outbreak. , Ebola virus is a lethal, ...
(Date:4/22/2014)... exposure to environmental enrichment can induce neurogenesis ... and memory. Previous studies have demonstrated that ... superficial layer of the cerebral cortex of ... these neurons exhibit very weak properties of ... environmental enrichment has an impact on the ...
Breaking Biology News(10 mins):Full power: Alternative energy partnerships flourish in Asia 2Full power: Alternative energy partnerships flourish in Asia 3Inserm and the Institut Pasteur identify a new variant of Ebola virus in Guinea 2
... damage depends on the balance between the generation of scar ... significant minority of people who get injury to their organs ... to chronic liver disease and cirrhosis where the scarring is ... produce vital hormones and clotting factors. Liver scars also provide ...
... Barbara, Calif.) The National Institutes of Health (NIH) ... engineering, chemistry, and biology researchers to develop a highly ... The technology provides an entirely new method of discovering ... range of applications, including next-generation disease diagnosis at the ...
... (HGNS) produced marked dose-related increases in airflow in obstructive ... according to a new study from the Johns Hopkins ... efficacy of HGNS across a broad range of sleep ... airway pressure (CPAP), the current mainstay of treatment for ...
Cached Biology News:Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology 2Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology 3Hypoglossal nerve stimulation increases airflow during sleep in obstructive sleep apnea 2
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... Arizona (PRWEB) January 15, 2014 2013 ... for Scottsdale’s Brain State Technologies®. They saw continued independent ... Medical Center who were awarded a $1 million grant ... published in “Brain and Behavior” a peer reviewed journal, ...
(Date:1/14/2014)... January 14, 2014 Carahsoft and CDS ... January 23, 2014 at 2pm EST (11am PST), “Natural ... topic focuses on how technology can turn raw, heterogeneous ... for government agencies. The online webinar will last approximately ...
(Date:1/14/2014)... Texas , Jan. 14, 2014 The ... and research medicinal plants and therapeutic derivatives thereof ... health professionals, and researchers about the challenges of ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
... NxStage Medical, Inc. (Nasdaq: NXTM ), a ... to release its financial results for the first quarter ... before the opening of the financial markets.NxStage will also ... on Friday, May 8, 2009 to discuss its first ...
... Presentation Highlights Anti-Tumor effects of KRX-0401 (Perifosine)NEW YORK, ... KERX ) today announced multiple presentations of ... (perifosine), the company,s lead anti-cancer compound, at the ... being held in Denver, Colorado. Abstracts selected for ...
... Data demonstrates that ProLindac should provide sustained tumor exposure ... low hematoxicity observed in the clinic -DALLAS, April 21 ... ACCP) announced today that its collaborators at ... on its lead anticancer compound, ProLindac(TM), at the American ...
Cached Biology Technology:NxStage to Report First Quarter 2009 Financial Results 2Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research 2Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research 3Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research 4Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting 2Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting 3Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting 4
...
Mouse monoclonal antibody raised against a partial recombinant L3MBTL2. NCBI Entrez Gene ID = L3MBTL2...
Mouse monoclonal antibody raised against a partial recombinant QARS. NCBI Entrez Gene ID = QARS...
96-well format (For processing samples on microplate-size MALDI target plates such as those from Bruker, Shimadzu, Thermo, and PerkinElmer) Packaging: 2 / pack...
Biology Products: