Navigation Links
New immune defense enzyme discovered
Date:4/3/2012

This release is available in German.

Neutrophil granulocytes comprise important defences for the immune system. When pathogenic bacteria penetrate the body, they are the first on the scene to mobilise other immune cells via signal molecules, thereby containing the risk. To this end, they release serine proteases enzymes that cut up other proteins to activate signal molecules. Scientists at the Max Planck Institute of Neurobiology in Martinsried have now discovered a new serine protease: neutrophil serine protease 4, or NSP4. This enzyme could provide a new target for the treatment of diseases that involve an overactive immune system, such as rheumatoid arthritis.

The functioning of the immune system is based on the complex interplay of the most diverse cells and mediators. For example, neutrophil granulocytes (a group of specialized white blood cells) react to bacteria by releasing substances called serine proteases. These enzymes are able to activate signal molecules, such as the chemokines, by cleaving them at a specific position on the molecule. The active signal molecules then guide other immune cells to the focus of inflammation in order to destroy the pathogens.

A research team led by Dieter Jenne at the Max Planck Institute of Neurobiology in Martinsried has come across a previously unknown protease in humans: neutrophil serine protease 4, or NSP4. "The special thing about this enzyme is that it cuts proteins that have the amino acid arginine at a particular point", says Dieter Jenne, research group leader at the Martinsried-based Institute. "This is where NSP4 differs from the other three known neutrophil serine proteases, which are similar in molecular structure, but have a different recognition motif." The scientists may be able to harness this difference to develop an active substance that specifically inhibits NSP4, there
'/>"/>

Contact: Dr. Dieter Jenne
djenne@neuro.mpg.de
49-898-578-3588
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Key to immune system disease could lie inside the cheek
2. Immune system implicated in prematurity complication
3. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
4. UCI-led study uncovers how Salmonella avoids the bodys immune response
5. U of Alberta researcher steps closer to understand autoimmune diseases
6. Depression could be evolutionary byproduct of immune system
7. Secrets of immune response illuminated in new study
8. Human immune cells react sensitively to stress
9. Stealthy leprosy pathogen evades critical vitamin D-dependent immune response
10. Aiding cancer therapy by mathematically modeling tumor-immune interactions
11. UCSF team uncovers how immune cells move against invaders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New immune defense enzyme discovered
(Date:11/15/2014)... Nov. 13, 2014  While we may still be a ... used in "Star Trek" to gain instant access to all ... work with smartphones and tablets for monitoring and measuring our ... world. This may seem a tad Orwellian to some, but ... some of these technological opportunities into their healthcare regime. ...
(Date:11/7/2014)... by Dr. Debra Auguste, associate professor, biomedical engineering, ... City College of New York, have identified a ... one of the most aggressive forms of breast ... a high mortality rate owing to aggressive proliferation ... options. However, Professor Auguste,s team, discovered the overexpression ...
(Date:11/6/2014)... because of metastasis, yet progress in preventing and ... "It,s been particularly challenging to design drugs that ... in systems biology at Harvard Medical School. ... they,ve already metastasized." , Gujral and colleagues have ... researchers better understand how metastasis begins. Their findings ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Migration negation 2Migration negation 3
... in the open ocean may force scientists to rethink ... ocean ecosystems. A research team led by Jonathan Zehr, ... Santa Cruz, characterized the new microbe by analyzing its ... to grow it in the laboratory. Zehr ...
... professor at The University of Texas at Austin, will ... on Greenhouse Gas Control Technologies that examines a unique ... of CO2 escaping via buoyancy. When: Nov. 19, ... 2500 Calvert St. NW, in Washington, D.C. The research ...
... University Biologist Richard Bonneau has been named one of ... Discover magazine. Bonneau, 33, is an assistant ... and Systems Biology and the university,s Courant Institute of ... appears in Discover,s December issue. Bonneau,s ...
Cached Biology News:Mysterious microbe may play important role in ocean ecology 2Mysterious microbe may play important role in ocean ecology 3Engineer to present leak-proof method for carbon dioxide storage at international conference 2NYU biologist Bonneau named among 20 "visionary" scientists under 40 by Discover magazine 2
(Date:11/26/2014)... PHILADELPHIA , Nov. 26, 2014 Space ... Human exploration of space requires astronauts to maintain consistently ... and success, and prevent potential errors and accidents. Despite ... is known about how cognition is affected by prolonged ... Now, Penn Medicine researchers are poised to ...
(Date:11/26/2014)... November 26, 2014 PMG Research, Inc. ... PMG Research is a network of sites that provide clinical ... over 2 million patient lives through its partnerships with large ... of 11 hub site locations in the Southeastern United States ... term of the board will be held by: ...
(Date:11/26/2014)... Continuing its award-winning streak, Nerium International, the ... Awards for outstanding creative achievement by its marketing and ... the organization’s top honor, in the Branding category for ... April of this year. The event showcased top speakers ... was awarded a Gold MarCom Award in the Special ...
(Date:11/26/2014)... SoundConnect , an award winning unified communications ... Darren Suders has joined the team as Director of ... partner program through innovative offerings, consistent partner ... brings more than 10-years of channel telecommunication experience to ... from policy development, to partner education and to expansion. ...
Breaking Biology Technology:Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2SoundConnect Appoints Director of Channel Development & Sales 2
... Silence Therapeutics plc (AIM: SLN), a leading international ... partner, Quark Pharmaceuticals, Inc. ("Quark"), has announced the grant ... worldwide license to develop and commercialise QPI-1002, a p53 ... Quark is currently conducting a Phase II ...
... 19 US Oncology, Inc., the nation,s ... than two decades it has played a role in ... the US Food and Drug Administration (FDA). ... http://www.newscom.com/cgi-bin/prnh/20100517/DA06089LOGO ) Tasigna ® (nilotinib) capsules, ...
... Researchers have developed an improved coating technique that could ... patients, own bone. The stronger connection -- created by ... growth -- could allow the implants to last longer. ... engineered protein that mimics the body,s own cell-adhesion material ...
Cached Biology Technology:Silence Therapeutics' Partner Quark Signs Exclusive Option Agreement With Novartis for Development and Commercialisation of QPI-1002 2US Oncology Helps Deliver Latest Cancer Therapies Through Local Community Access to Cutting Edge Research 2US Oncology Helps Deliver Latest Cancer Therapies Through Local Community Access to Cutting Edge Research 3US Oncology Helps Deliver Latest Cancer Therapies Through Local Community Access to Cutting Edge Research 4Titanium coating with protein 'flower bouquet' nanoclusters strengthens implant attachment 2Titanium coating with protein 'flower bouquet' nanoclusters strengthens implant attachment 3
...
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
TRIzol Reagents are ready-to-use monophasic solutions of phenol and guanidine isothiocyanate suitable for isolating total RNA DNA and proteins (16)....
...
Biology Products: