Navigation Links
New imaging method sheds light on cell growth
Date:8/25/2011

CHAMPAIGN, Ill. University of Illinois researchers are giving a light answer to the heavy question of cell growth.

Led by electrical and computer engineering professor Gabriel Popescu, the research team developed a new imaging method called spatial light interference microscopy (SLIM) that can measure cell mass using two beams of light. Described in the Proceedings of the National Academy of Sciences, the SLIM technique offers new insight into the much-debated problem of whether cells grow at a constant rate or exponentially.

SLIM is extremely sensitive, quantitatively measuring mass with femtogram accuracy. By comparison, a micron-sized droplet of water weighs 1,000 femtograms. It can measure the growth of a single cell, and even mass transport within the cell. Yet, the technique is broadly applicable.

"A significant advantage over existing methods is that we can measure all types of cells bacteria, mammalian cells, adherent cells, nonadherent cells, single cells and populations," said Mustafa Mir, a graduate student and a first author of the paper. "And all this while maintaining the sensitivity and the quantitative information that we get."

Unlike most other cell-imaging techniques, SLIM a combination of phase-contrast microscopy and holography does not need staining or any other special preparation. Because it is completely non-invasive, the researchers can study cells as they go about their natural functions. It uses white light and can be combined with more traditional microscopy techniques, such as fluorescence, to monitor cells as they grow.

"We were able to combine more traditional methods with our method because this is just an add-on module to a commercial microscope," Mir said. "Biologists can use all their old tricks and just add our module on top."

Because of SLIM's sensitivity, the researchers could monitor cells' growth through different phases of the cell cycle. They found tha
'/>"/>

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2

Related biology news :

1. SNM releases new fact sheet on breast cancer and molecular imaging
2. Cheskin Added Value EVP Lee Shupp Discusses Evolving Dynamics of Consumers and Imaging Tech at 6Sight
3. MU brain imaging center provides research for autism, schizophrenia and Parkinsons disease
4. Similarities in imaging the human body, Earths crust focus of conference at UH
5. UNC expands brain imaging study of infants at risk for autism
6. Studies on imaging and tracking transplanted cells
7. Fattysaurus or thinnysaurus? How dinosaurs measure up with laser imaging
8. SNM Symposium on Multimodality Cardiovascular Molecular Imaging
9. Ultrasound imaging now possible with a smartphone
10. First neuroimaging study examining motor execution in children with autism reveals new insights
11. Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New imaging method sheds light on cell growth
(Date:7/9/2014)... study co-authored by a University of Guelph scientist ... tags shows long-term exposure to a neonicotinoid pesticide ... The research by Nigel Raine, a professor in ... of Imperial College London was published July 9 ... Ecology . , The study shows how long-term ...
(Date:7/9/2014)... announce themselves with pain and fever but often can be ... are sneaky and hard to beat. Now, scientists have built ... tiny DNA pyramids. Published in the journal ACS Applied ... flag bacteria and kill more of them than medicine alone. ... infectious pathogens can lie in wait, undetectable in the human ...
(Date:7/9/2014)... A drug candidate developed by researchers at ... Sciences (NCATS) and its collaborators to treat ... Baxter International,s BioScience business. The drug candidate, ... target the underlying molecular mechanism of sickle ... clinical development activities required for regulatory approval ...
Breaking Biology News(10 mins):Bee foraging chronically impaired by pesticide exposure: Study 2First drug candidate from NIH program acquired by biopharmaceutical company 2First drug candidate from NIH program acquired by biopharmaceutical company 3First drug candidate from NIH program acquired by biopharmaceutical company 4
... University of Reading ,s Centre for Agri-Environmental Research, and funded ... Insect Pollinators Initiative Crops project, indicates that demand ... the number of colonies across Europe. The study, led ... colonies in 41 European countries with their demands for pollination ...
... Philadelphia, PA, January 9, 2014 Tobacco smoking by ... health risk because of smoking,s adverse effects on the ... is linked to numerous negative outcomes, including low birth ... attention deficit disorder, conduct disorder, and nicotine use in ...
... the School of Medicine at The University of Texas Health ... 31 for his discovery that a class of compounds is ... covers novel methods of preventing or treating neuronal damage, and ... based on this invention. Cell, animal and human ...
Cached Biology News:EU policy is driving up demand for pollination faster than honeybee numbers 2Maternal stress hormones and maternal smoking increase daughter's risk of nicotine dependence 2Discovery leads to patent for novel method of treating traumatic brain injury 2Discovery leads to patent for novel method of treating traumatic brain injury 3
(Date:1/15/2014)... 15, 2014 Look inside the new ... for the lab, from fluid handling to instruments to ... ship when you order. , Preferred Solutions features ... from the L/S® model for precise flow control and ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 AudioNotch ... experimental new therapy for the treatment of tinnitus. Patients ... tinnitus frequency, and over a period of weeks to months, ... Sound Therapy in two forms: Notched Music and Notched White ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... for functional food partners and market entrance, ... Neptune Technologies &,Bioressources Inc. ("Neptune") (NASDAQ.NEPT - ... has been determined to be,safe as a ... for the,commercialization of NKO(R) incorporated into different ...
... after biological olfaction, the challenge has been to generate ... complexity to detect odors in the real world. A ... with exact chemical precision and reproducibility. , In a ... PLoS Biology, Joel White, Mary AtKisson, John Kauer and ...
... /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI , TSX: ANP), a ... discussing its,financial results for the fourth quarter and year ended December ... 2008 at 11:00 AM ET (8:00 ... Dial information is as follows: ...
Cached Biology Technology:Neptune Technologies receives GRAS notification in the United States 2Neptune Technologies receives GRAS notification in the United States 3Angiotech Pharmaceuticals, Inc. - Notice of Conference Call and Webcast 2
... photographic filter (S37100, Photographic Filters for ... ideal for black-and-white photography of gels ... gel stain, the safer ethidium bromide ... photographic filter is identical to the ...
Mature rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and processed within 45 minutes. It is then filtered through gauze, pooled in an ...
LAL Chromogenic Endpoint assay...
uncoupling protein 2 (mitochondrial, proton carrier), mRNA (cDNA clone MGC:19567 IMAGE:4335185), complete cds...
Biology Products: