Navigation Links
New imaging advance illuminates immune response in breathing lung
Date:12/20/2010

Fast-moving objects create blurry images in photography, and the same challenge exists when scientists observe cellular interactions within tissues constantly in motion, such as the breathing lung. In a recent UCSF-led study in mice, researchers developed a method to stabilize living lung tissue for imaging without disrupting the normal function of the organ. The method allowed the team to observe, for the first time, both the live interaction of living cells in the context of their environment and the unfolding of events in the immune response to lung injury.

The finding impacts disease research, the authors say, because the ability to image the lung and other organs with minimum tissue disruption allows scientists to look deeper into the many physiological aspects of injury and diseases like diabetes or cancer.

"The nature of disease is complex, so if scientists can observe in real-time what's happening in tumors or immune responses as they occur, we can find new ways to intervene," said senior author Max Krummel, PhD, UCSF associate professor of Pathology, whose lab developed the new imaging technique for seeing minute details of cellular interaction in tissues.

"We figured out a method for holding cells still enough to image them without interrupting their normal processes. This enabled us to observe cellular events as they happen naturally rather than the usual way, which is to stop the motion of cellular processes in order to photograph them."

The research, published online this week in Nature Methods, includes videos of these immune cell interactions: http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.1543.html.

To achieve such clear imaging of the fast-moving lung cells, the team developed a custom rig device that applies a gentle amount of suction to the tissue surface, holding the region for viewing in
'/>"/>

Contact: Lauren Hammit
lauren.hammit@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. SNM releases new fact sheet on breast cancer and molecular imaging
2. Cheskin Added Value EVP Lee Shupp Discusses Evolving Dynamics of Consumers and Imaging Tech at 6Sight
3. MU brain imaging center provides research for autism, schizophrenia and Parkinsons disease
4. Similarities in imaging the human body, Earths crust focus of conference at UH
5. UNC expands brain imaging study of infants at risk for autism
6. Studies on imaging and tracking transplanted cells
7. Fattysaurus or thinnysaurus? How dinosaurs measure up with laser imaging
8. SNM Symposium on Multimodality Cardiovascular Molecular Imaging
9. Ultrasound imaging now possible with a smartphone
10. First neuroimaging study examining motor execution in children with autism reveals new insights
11. Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... ALBUQUERQUE, N.M. A credit-card-sized anthrax detection cartridge developed ... small business makes testing safer, easier, faster and cheaper. ... causes anthrax, is commonly found in soils all over ... illness in both humans and animals. The bacteria can ... to B. anthracis may occur through skin ...
(Date:4/17/2014)... One day about eight years ago, Katia Silvera ... and her father were on a field trip in a ... orchid they had never seen before. , Unable to identify ... The orchid turned out to be an unnamed species. ... silverarum . , "Lophiaris" is the genus name, comprising about ...
(Date:4/17/2014)... in France have hit on a novel method ... the correct and most effective treatment possible., Kidney ... western and developing world. If left untreated, apart ... renal failure and other complications. In many patients ... Clearly a more effective pathological approach to diagnosis ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3
... scientists from Texas A&M University and The University ... that naturally occurring endogenous retroviruses are required for ... class of endogenous retroviruses, known as endogenous retroviruses ... critical during the early phase of pregnancy when ...
... to use a brief burst of electricity to release biomolecules ... could someday be used to dispense small amounts of medicine ... method also may be useful in chemical reactions that require ... , The technique was described Sept. 10 in a presentation ...
... animals may have been responsible for the deadly 1998?000 ... the Democratic Republic of the Congo, according to an ... New England Journal of Medicine. , Daniel G. ... School of Public Health and Tropical Medicine and an ...
Cached Biology News:Researchers discover that sheep need retroviruses for reproduction 2Electric jolt triggers release of biomolecules, nanoparticles 2
(Date:1/14/2014)... 2014 Carahsoft and CDS Federal Services ... 2014 at 2pm EST (11am PST), “Natural Language Processing: ... on how technology can turn raw, heterogeneous data into ... agencies. The online webinar will last approximately one hour. ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of strategic ... business, and media events in the United States ... associate Virginia Cox , JD, is returning to the firm,s ... Cox re-joins 3D after more than two years of service ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging ... to serve the wound care market. , Free report ... was restructured with a seasoned management team and Board, ...
(Date:1/14/2014)... DIEGO and BETHESDA, Md. ... are joining together with two institutes from the National ... reliable tools for bringing safer, more effective treatments to ... the National Center for Advancing Translational Sciences (NCATS) and ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... Mass., March 21, 2011 Interleukin Genetics, Inc. (OTCQB: ILIU) ... fourth quarter and full fiscal year ended December 31, ... establishing our business in 2010.  In collaboration with Stanford ... March 2010 showing the important role applied genetics has ...
... announces that a new market research report ... Global Angiongenesis Inhibitors and Stimulators Industry ... This report analyzes the worldwide markets ... Million by the following product segments - ...
... Chairman of the Board of Directors of the Pittsburgh ... and customized company formation and business growth services to ... Manzetti and the Pittsburgh Life Sciences Greenhouse for being ... category winner at the 2011 Pennsylvania Technology Awards Gala ...
Cached Biology Technology:Interleukin Genetics Reports Fourth Quarter and Year End 2010 Financial Results 2Interleukin Genetics Reports Fourth Quarter and Year End 2010 Financial Results 3Interleukin Genetics Reports Fourth Quarter and Year End 2010 Financial Results 4Interleukin Genetics Reports Fourth Quarter and Year End 2010 Financial Results 5Interleukin Genetics Reports Fourth Quarter and Year End 2010 Financial Results 6Interleukin Genetics Reports Fourth Quarter and Year End 2010 Financial Results 7Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 2Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 3Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 4Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 5Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 6Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 7Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 8Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 9Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 10Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 11Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 12Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 13Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 14Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 15Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 16Reportlinker Adds Global Angiongenesis Inhibitors and Stimulators Industry 17John W. Manzetti and the Pittsburgh Life Sciences Greenhouse Recognized as 2011 Outstanding Leader in Technology 2
Agar, 5 lb. Bacteriological.Moisture: < 10%, ash: < 6.5%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
... Synthetic peptide derived from an internal region ... target of rapamycin FRAP RAFT1 RAPT1). ... On Western blots it identifies the ... Human (positive control: HEK293 cell lysates). Based ...
...
Biology Products: