Navigation Links
New hope for young leukemia patients?
Date:11/16/2011

This press release is available in French.

MONTREAL, November 15, 2011 The development of simple tests to predict a leukemic relapse in young patients is a step closer thanks to researchers from the Sainte-Justine University Hospital Research Center and the University of Montreal. Approximately 20 percent of young leukemia patients who are treated with stem cells derived from umbilical cord blood will experience leukemic relapse. The researchers' findings, published recently in Blood, demonstrate that the blame falls partially on a subset of white blood cells called "T cells." Until now, this process had been poorly understood.

"We have shown that a particular marker on the T-cells, PD-1, was found significantly more frequently in those young patients in whom relapses were about to occur," says lead author, Dr. Hugo Soudeyns, an investigator at the Sainte-Justine University Hospital Research Center, affiliated with Universit de Montreal. "PD-1 is also an indicator of 'T cell exhaustion', a process whereby T cells lose their capacity to multiply and are less effective at fighting viruses and cancer cells."

Window of vulnerability

Dr. Soudeyns and his colleagues analyzed blood samples from young children who received an umbilical cord blood transplant for the treatment of blood disorders, including leukemia. They were particularly interested in studying the three to six month time period post-transplantation, when the children were most susceptible to both relapse and infection. During this time, expression of the PD-1 marker peaked, suggesting that many of these T cells were at the end of their life cycle and thus less effective.

"Our findings suggest that measurement of exhaustion markers such as PD-1 could serve as an early predictor of leukemic relapse a very serious complication," says Dr. Soudeyns. "Our next step is to repeat these experiments in larger groups of patients."


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related biology news :

1. Researchers discover that growing up too fast may mean dying young in honey bees
2. Study: urban black bears live fast, die young
3. Research shows that time invested in practicing pays off for young musicians
4. 12 outstanding young scientists named as EMBO Young Investigators
5. Old flies can become young moms
6. Elsevier announces winners of 3rd Annual Scopus Young Indian Scientist Award
7. Old and young brains rely on different systems to remember emotional content
8. Young adults need to make more time for healthy meals
9. Dont go changing: New chemical keeps stem cells young
10. NSF-funded workshops help young researchers teach science
11. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... ... May 24, 2016 , ... ... and traumatic injuries, will be accelerated by research at Worcester Polytechnic Institute (WPI) ... of wound healing and tissue regeneration. , The novel method, developed by WPI ...
(Date:5/23/2016)... Antonio, Texas (PRWEB) , ... May 23, 2016 , ... The need for blood donations ... released this week by the South Texas Blood & Tissue Center, blood donations are on ... than 30 years, and they are down 21 percent in South Texas in the last ...
(Date:5/23/2016)... LONDON , May 23, 2016 ... Efficiency by 40% - Frontage Implement a Single Platform ... Quality, Compliance and Traceability Within the Bioanalytical lab Frontage ... the United States and China ... across its laboratory facilities. In addition to serving as the global ...
(Date:5/20/2016)... , ... May 20, 2016 , ... The leading Regenerative ... its most experienced veterinary clients have treated over 100 of their own patients with ... to provide the highest level of care for their patients. , The veterinarians ...
Breaking Biology Technology: