Navigation Links
New hope for early detection of stomach cancer
Date:3/18/2014

University of Adelaide research has provided new hope for the early detection of stomach cancer with the identification of four new biomarkers in the blood of human cancer patients.

Stomach or gastric cancer is the fourth most common cancer in the world and the second leading cause of death due to cancer.

"Stomach cancer is typically without symptoms in the early stages so most cancers are not diagnosed until the later stages, and the survival rates are therefore low," says Associate Professor Peter Hoffmann, project leader and Director of the University's Adelaide Proteomics Centre.

"Endoscopic investigations are invasive and expensive and most are generally not conducted until the cancer is at an advanced stage.

"A non-invasive, inexpensive screening technique through a simple blood test for the early detection of stomach cancer would make a huge difference in the survival outcomes for people with this disease."

Published in journal Biochimica et Biophysica Acta, the researchers have identified four new proteins that change in concentration in the blood of stomach cancer patients.

In this latest research, conducted by Dr Julia Humphries who is now at SA Pathology and Dr Megan Penno, they showed differences in the four protein levels between serum samples from 37 gastric cancer patients, including 11 early stage cancer patients, and the controls which included healthy and non-cancerous patients with other gastric disease.

All four proteins afamin, clusterin, haptoglobin and vitamin D binding protein (VDBP) were individually superior to a current clinical marker CA72-4 in discriminating stomach cancer from healthy controls.

"Using the four markers together produces high levels of selectivity and sensitivity in detecting stomach cancer," says Associate Professor Hoffmann.

The biomarkers are subject to a PCT (Provisional Cooperation Treaty) patent and commercial partners are being sought.


'/>"/>

Contact: Peter Hoffmann
Peter.Hoffmann@adelaide.edu.au
61-043-407-9108
University of Adelaide
Source:Eurekalert

Related biology news :

1. Lower IQ in teen years increase risk of early-onset dementia
2. Early warning system for epidemics
3. Discovery by Baylor University researchers sheds new light on the habitat of early apes
4. Dr. Jeremy Robinson of NRL wins Presidential Early Career Award
5. Scientists reveal why life got big in the Earths early oceans
6. Researchers discover potential drug targets for early onset glaucoma
7. Overexpression of splicing protein in skin repair causes early changes seen in skin cancer
8. White House lauds ONR-funded researchers for early success
9. Autism Speaks awards nearly $2.7 million for new research projects
10. Molecular markers used for assessment of early sciatic nerve injury
11. International gene therapy trial for bubble boy disease shows promising early results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/4/2017)... April 4, 2017   EyeLock LLC , a ... the United States Patent and Trademark Office (USPTO) has ... the linking of an iris image with a face ... represents the company,s 45 th issued patent. ... very timely given the multi-modal biometric capabilities that have ...
Breaking Biology News(10 mins):
(Date:9/14/2017)... ... 14, 2017 , ... AIM Global, the worldwide standards agency for AIDC and ... 2017 Case Study Competition for AIDC. The award is given to those in ... push the adoption of automated data collection systems further. The TRACTUS platform, by ...
(Date:9/12/2017)... , ... September 12, 2017 , ... ... and highly scalable cloud-based platform for ambulatory patient monitoring and clinical trial support, ... Advance Clinical Trials conference in Boston. , Launched in 2005, PhysIQ leverages ...
(Date:9/12/2017)... ... September 12, 2017 , ... Soybean researchers ... to submit a "pre-proposal” by October 15, prior to completing a full grant ... are aligned with our priorities, and to encourage researchers to further develop ones ...
(Date:9/12/2017)... ... September 11, 2017 , ... Global molecular ... today that Holotype HLA and other Omixon products will be featured among eight ... American Society for Histocompatibility and Immunogenetics (ASHI) in San Francisco, CA. Additionally, ...
Breaking Biology Technology: