Navigation Links
New hope for deadly childhood bone cancer
Date:8/31/2009

SALT LAKE CITY, Aug. 31, 2009 Researchers at Huntsman Cancer Institute (HCI) at the University of Utah have shed new light on Ewing's sarcoma, an often deadly bone cancer that typically afflicts children and young adults. Their research shows that patients with poor outcomes have tumors with high levels of a protein known as GSTM4, which may suppress the effects of chemotherapy. The research is published online today in the journal Oncogene.

"Doctors and researchers have long known that certain Ewing's sarcoma patients respond to chemotherapy, but others don't even though they have the same form of cancer," says HCI Investigator Stephen Lessnick, M.D., Ph.D. "Our research shows that GSTM4 is found in high levels among those patients where chemotherapy doesn't seem to work. It's found in low levels in patients where chemotherapy is having a more positive effect."

The research could lead to drugs that can suppress GSTM4 in certain patients. It also could lead to a screening test that could reveal which therapies will be most effective for patients. "GSTM4 doesn't seem to suppress the benefits of all chemotherapy drugs, just certain ones. A GSTM4-based test could help to identify the best therapy for each individual patient," Lessnick says.

Ewing's sarcoma is the second most common bone cancer in children and adolescents. The five-year survival rate is considered poor at about 30 percent if the cancer has spread by the time it is diagnosed, and there is an even poorer prognosis for patients who have suffered a relapse.

For this study, researchers focused on an abnormal protein known as EWS-FLI, which is found in most Ewing's sarcoma tumors. What they discovered is that EWS-FLI causes increased amounts of the GSTM4 gene and the protein it produces to be expressed in tumors, a previously unknown effect that led them to make the connection between poor outcomes and high levels of GSTM4. The discovery was made by focusing on repetitive DNA sequences called microsatellites. Microsatellites are sometimes referred to as "junk DNA" because they are not thought to have a normal role in the genome. By examining how EWS-FLI interacts with certain microsatellites, Lessnick and his team were able to identify GSTM4.

Lessnick says the next step in research is to focus on testing and treatments that may lead to better survival rates in patients. "Personalized medicine is the next frontier in the battle against cancer," he says. "We now know all cancers are not the same. By focusing on how these proteins are expressed in individual tumors, we may soon be able to offer the treatment that will work best for each patient, and that could lead to higher cure rates," he says.


'/>"/>

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Related biology news :

1. Komodo even more deadly than thought: Research
2. Scientists learn why the flu may turn deadly
3. FluChip technology licensed to combat deadly flu virus
4. TGen researchers discover possible way to block the spread of deadly brain tumors
5. Minimizing the spread of deadly Hendra virus
6. UNC study: Scientists identify chemical compound that may stop deadly brain tumors
7. University of Kansas graduate student researcher takes aim at deadly brain tumors
8. Scientists discover how deadly fungus protects itself
9. Study: Excessive use of antiviral drugs could aid deadly flu
10. Battling bacteria in the blood: Researchers tackle deadly infections
11. 15-state Southern obesity summit to focus on deadly epidemic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... 2016 Technology Enhancements Accelerate Growth of X-ray Imaging ... digital and computed radiography markets in Thailand ... Indonesia (TIM). It provides an in-depth ... well as regional market drivers and restraints. The study ... and market attractiveness, both for digital and computed radiography. ...
(Date:2/1/2016)... , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces ... personality, Joey Fatone . Las Vegas , ... --> Las Vegas , where Joey appeared ... The new video ad was filmed at the Consumer Electronics Show ... the Wocket booth to meet and greet fans. ...
(Date:1/22/2016)... January 22, 2016 ... addition of the  "Global Behavioral Biometric ... --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has ... Behavioral Biometric Market 2016-2020"  report to ... and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... 3, 2016 New Jersey Health Foundation (NJHF) ... million for researchers in New Jersey ... that demonstrates exciting potential.   James ... the New Jersey Health Foundation Research Grant Program ... educational institutions— Princeton University, Rutgers University, Rowan University ...
(Date:2/3/2016)... ... February 03, 2016 , ... StarNet Communications Corp, ... today announced the addition of a powerful “Session Preview” feature to its FastX ... state of the remote Linux desktop or other applications (sessions) they have running ...
(Date:2/3/2016)... 3, 2016  Today, Symphony Technology Group (STG) announced ... a leading provider of primary research and analytics-based insight ... Health , a global information and technology services company ... technologies will be integrated into IMS Health to form ... research capabilities. ...
(Date:2/3/2016)... ... February 03, 2016 , ... Marktech Optoelectronics, ... and wafers, and InP epi wafers based in Latham, New York, offers a ... transistors, and Avalanche photodiodes–to Si and InGaAs PIN photodiodes. But it is Marktech's ...
Breaking Biology Technology: