Navigation Links
New genomics study shows ancestry could help solve disease riddles
Date:10/25/2012

esearch for Scripps Health's genomic medicine program, and director of biostatistics and bioinformatics at STSI, "but it could be that they're still searching in the noise."

The new work offers a likely filter for much of that noise. The results show that comparing a person's DNA sequence against existing genomes for those whose ancestry is not sufficiently similar, as is typically the case, can cause serious problems. Countless differences that seem unique to a patient might instead be DNA variants carried by everyone with the same ancestry. A researcher might, for instance, identify hundreds of variants and not be able to zero in on the one responsible for a disease.

But the new results show that comparing closer ancestry matches will dramatically reduce the number of variants identified as potentially responsible for a disease, reducing a search to a workable number.

For the work, the team developed a tool called the Scripps Genome Adviser. This processing framework uses a supercomputer to incorporate a variety of databases and algorithms to identify DNA variants in a particular genome relative to reference genomes. It then uses algorithms to analyze these variants and predict whether they have any physiological effects, and if so what those might be.

The team began with nearly 60 whole human genome databases and ran three key types of computing experiments. First the researchers identified the number of variants in the reference human genomes and found that on average each has millions of variants, about 12,000 of which have functional effects. Then the scientists looked at the rates at which variants appeared in various ancestry lines.

Honoring Ancestry

Importantly, the scientists didn't stop there. They deliberately inserted a mutation known to cause disease into a genome, then ran this genome through the Adviser to see how effectively it could identify that known variant as unique.

Wh
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Physiological Genomics journal announces a major restructuring
2. 2 pioneering plant genomics efforts given a funding boost by National Science Foundation
3. ShanghaiBio Corporation Partners with Ingenuity Systems to Address Challenges in Analysis and Interpretation of Genomics Data
4. Elsevier launches new open access journal: Applied and Translational Genomics
5. The genomics symposium to boost the further development of cancer research
6. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
7. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
8. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
9. SDSCs big data expertise aiding genomics research
10. A new technique to study how myeloids become white blood cells
11. University of Toronto study demonstrates impact of adversity on early life development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New genomics study shows ancestry could help solve disease riddles
(Date:7/31/2014)... (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, ... publications, British Medical Journal Open (BMJ Open) ... BMJ Open article looked at the effects of ... that tree nut consumption resulted in a significant decrease ... ONE article focused on the effect of tree ...
(Date:7/30/2014)... regulate its genes, and adapt to changes in its ... regulation taking place in the truffle, is published in ... illustrates how the truffle deals with its complex genome,s ... may shed light on how traits like aroma and ... known as Prigord truffles, have a syrupy sweet flavor ...
(Date:7/30/2014)... until they hatched 4.5 years later, according to a ... PLOS ONE by Bruce Robison from Monterey ... have a single reproductive period during their life, where ... eggs until they hatch. Shallow-water octopuses typically care for ... is known about the brooding of deep-sea species. Using ...
Breaking Biology News(10 mins):New international tree nut council study looks at nuts, diabetes and metabolic syndrome 2How black truffles deal with the jumpers in their genome 2Deep-sea octopus has longest-known egg-brooding period 2
... nanotechnology fanciers suggest that, like proverbial birds of ... or clump together. This tendency, they ... manufacturing increases and the number of nanotechnology-enabled products ... Maynard, chief science advisor to the Project on ...
... completing the first large-scale report sequencing breast and colon ... studied the vast majority of protein-coding genes which now ... mutated in relatively few cancers. Their report, published ... indicates that while little is known about these less-commonly ...
... a reality today, but how can we find out about ... a full record of the Earths climate for several hundred ... that can be taken to the lab for analysis. Incredibly, ... Antarctic regions, and a European Science Foundation programme has a ...
Cached Biology News:Nanoparticle exposures happen, says expert 2Genome update defines landscape of breast and colon cancers 2Genome update defines landscape of breast and colon cancers 3European lead in reading past climates from ice cores 2European lead in reading past climates from ice cores 3
(Date:7/31/2014)... Indiana University Bloomington have described the self-assembly of ... with potential value for the field of organic ... cells. , Their paper, "Anion-Induced Dimerization of 5-fold ... Self-Assembled Crystals," has been published online by ... Society of Chemistry. It is the first collaboration ...
(Date:7/31/2014)... , July 31, 2014 According ... Research "Quantum Dots Market - Global Industry Analysis, Size, ... market was valued at USD 88.5 million in 2011, ... 2023, growing at a CAGR of 53.8% from 2013 ... Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html Increasing demand ...
(Date:7/31/2014)... NY (PRWEB) July 31, 2014 Graphite ... in high temperature oven carts. These bearings are uniquely ... in sealed ball bearings because of the high ... alumina requested help from the design engineers at Graphite ... a heating process. During their manufacturing operation, pans containing ...
(Date:7/31/2014)... York , July 31, 2014 ... Transparency Market Research "Electrodes for Medical Devices Market (Diagnostic ... Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and ... Trends and Forecast, 2013 - 2019," the global electrodes ... million in 2012 and is estimated to reach a ...
Breaking Biology Technology:Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6
... J. Samskog, H. Wadensten, and J. Flensburg ... Sweden , , ... analyse phosphopeptides in mouse brain tissue. The trypsin-digested tissue was separated ... using Ettan MDLC. The detection was performed by mass spectrometry using ...
... Key words: SPA Imaging Beads ... , SPA Imaging Assays ... an SPA Imaging Bead in order to generate a signal. Polystyrene (PS) ... rabbit secondary antibodies during the assay. The Donkey Anti-Rabbit PS SPA Imaging ...
... , ... Imaging Beads , ... (CGRP) is believed to have an important physiological role in the central ... basilar arteries, in vitro studies have identified a number of ...
Cached Biology Technology:Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 2Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 3Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 4Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 2Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 3Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 4The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 2The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 3The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 4The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 5
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
Rabbit anti-Junctophilin-4 (C-term)...
... CopyControl™ PCR Cloning Kits are designed to speed ... that all PCR products, regardless of sequence or ... PCR products including those that are difficult to ... may be unstable or code for potentially detrimental ...
Size & Applications: 20 ml Storage Temp.: -20C Shelf Life: 12 months ...
Biology Products: