Navigation Links
New genetic tool helps researchers to analyze cells' most important functions
Date:4/11/2011

Although it has been many years since the human genome was first mapped, there are still many genes whose function we do not understand. Researchers from the University of Gothenburg, Sweden, and the University of Toronto, Canada, have teamed up to produce and characterize a collection of nearly 800 strains of yeast cells that make it possible to study even the most complicated of genes.

One common way of studying the role of genes in cells is to remove a gene and investigate the effect of the loss. Genes are very similar in both yeast and people, which is one reason why the baker's and brewer's yeast Saccharomyces cerevisiae has become a firm favourite with geneticists and in yeast it is easy to make this kind of genetic change.

However, this does not work for many genes as the loss causes the cells to die. These are known as essential genes and are therefore difficult to study. This is a major problem for researchers as essential genes are often involved in crucial life processes. These essential genes are also the most well-conserved over long evolutionary distances, like between humans and yeast.

Together with researchers from the University of Toronto, Anders Blomberg and Jonas Warringer from the University of Gothenburg's Department of Cell- and Molecular Biology have produced a collection of nearly 800 strains of yeast cells where the function of these essential genes can be studied. This new genetic tool is now being made available to other researchers.

"The trick is to use temperature-sensitive mutants for the genes you want to study," says professor Anders Blomberg. "These mutants have amino acid changes, which make the resultant protein sensitive to higher temperatures but able to function normally at normal temperatures. And at intermediary temperatures one can set the desired activity of the mutant protein."

The Gothenburg researchers have worked for many years on characterising the changes in yeast mutants that result from genetic changes or environmental factors automatically and on a large scale. They will continue to develop and characterize the new collection of yeast cells to facilitate the systematic analysis of the function of all essential genes.


'/>"/>

Contact: Anders Blomberg
anders.blomberg@cmb.gu.se
46-031-786-2589
University of Gothenburg
Source:Eurekalert

Related biology news :

1. Rare genetic disorder gives clues to autism, epilepsy, mental retardation
2. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
3. Study finds genetic variant plays role in cleft lip
4. Genetic finding implicates innate immune system in major cause of blindness
5. American College of Medical Genetics receives $13.5M NIH contract
6. Clue to genetic cause of fatal birth defect
7. Can genetic information be controlled by light?
8. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
9. Modern genetics vs. ancient frog-killing fungus
10. Genetic based human diseases are an ancient evolutionary legacy
11. Genetic evidence for avian influenza movement from Asia to North America via wild birds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)...   Acuant , a leading provider of data ... to new and core technologies building upon the acquisition ... and desktop Acuant FRM TM facial recognition and ... time manual review of identity documents by accredited professionals. ... and most accurate capture software to streamline workflows by ...
(Date:2/24/2017)... , Feb. 24, 2017  EyeLock LLC, a leader ... its elite iris biometric solution on the latest ... LTE at Mobile World Congress 2017 (February ... Booth in Hall 3, Stand 3E10. ... Qualcomm Haven™ security platform—a combination of hardware, ...
(Date:2/14/2017)... 14, 2017  Wake Forest Baptist Medical Center today ... chief executive officer (CEO). Freischlag joins the medical center ... McConnell , M.D., who last year announced that he ... Center, after leading it since 2008.   ... Wake Forest Baptist,s academic health system, which includes Wake ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... ... March 22, 2017 , ... Researchers face a fundamental ... samples to full-size tissues, bones, even whole organs to implant in people to ... blood deep into the developing tissue. , Current bioengineering techniques, including 3-D ...
(Date:3/22/2017)... 22, 2017 Good Start Genetics, a leading ... the 130 million covered lives mark through its most ... Texas . With newly signed contracts nationally ... enjoy strong payor acceptance based on the quality of ... genetic counseling, its industry-leading customer care and support and ...
(Date:3/22/2017)... New York , March 22, 2017 ... is largely fragmented, states a research report by Transparency ... S.A., Pfizer Inc., Amgen Inc., and AbbVie Inc., accounted ... in 2015. The prominent players in this market are ... expand their product portfolio, which is likely to lead ...
(Date:3/22/2017)... March 22, 2017   Boston Biomedical , an ... designed to target cancer stemness pathways, today announced its ... as Chief Executive Officer, effective April 24, 2017. ... J. Li , M.D., FACP, who has led Boston ... Under his leadership, Boston Biomedical has grown from a ...
Breaking Biology Technology: