"One of the most exciting aspects of this work is that we've uncovered a new clue about the biology of diabetes," said co-senior author David Altshuler, deputy director and chief academic officer at the Broad Institute and a Harvard Medical School professor at Massachusetts General Hospital (MGH). "We are now hard at work trying to figure out what is being transported, how this influences triglyceride metabolism, and what steps lead to the development of type 2 diabetes."
The team's ultimate goal is to leverage a deeper understanding of this pathway to find new drug targets for treating diabetes. The Broad Institute recently announced that the Carlos Slim Foundation has made an additional contribution of $74M to launch the second phase (SIGMA 2) of the biomedical partnership that made the discovery of SLC16A11 and many other discoveries possible. SIGMA 2 will, among other things, help fund studies of this gene in cells and in mice, allow researchers to study the variant in more samples from people in Mexico City and Boston, and gain insights into the progression of the disease.
|Contact: Nicole Davis|
Broad Institute of MIT and Harvard