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New genetic research finds shark, human proteins stunningly similar
Date:12/5/2013

ITHACA, N.Y. Despite widespread fascination with sharks, the world's oldest ocean predators have long been a genetic mystery. The first deep dive into a great white shark's genetic code has fished up big surprises behind a design so effective it has barely changed since before dinosaurs roamed.

Cornell researchers have discovered that many of the endangered great white shark's proteins involved in an array of different functions including metabolism match humans more closely than they do zebrafish, the quintessential fish model.

Michael Stanhope, professor of evolutionary genomics at Cornell's College of Veterinary Medicine, and scientists at the Save Our Seas Shark Research Center at Nova Southeastern University published the study in the November issue of BMC Genomics. It lays the foundation for genomic exploration of sharks and vastly expands genetic tools for their conservation, said Stanhope.

"We were very surprised to find, that for many categories of proteins, sharks share more similarities with humans than zebrafish," Stanhope said. "Although sharks and bony fishes are not closely related, they are nonetheless both fish while mammals have very different anatomies and physiologies. Nevertheless, our findings open the possibility that some aspects of white shark metabolism, as well as other aspects of its overall biochemistry, might be more similar to that of a mammal than to that of a bony fish."

The study launched when Stanhope and Nova Southeastern professor Mahmood Shivji received a Save Our Seas Foundation grant and a rare gift of a great white shark heart. The heart had been autopsied from an illegally fished shark, confiscated by government authorities and donated to their project.

Of particular interest was that white shark had a closer match to humans for proteins involved in metabolism.

"Sharks have many fascinating characteristics," said Stanhope. "Some give live birth to fully f
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Contact: Joe Schwartz
joe.schwartz@cornell.edu
607-254-6235
Cornell University
Source:Eurekalert

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