Navigation Links
New genetic path for scleroderma
Date:3/19/2012

CHICAGO --- A genetic pathway previously known for its role in embryonic development and cancer has been identified as a target for systemic sclerosis, or scleroderma, therapy. The finding, discovered by a cross-disciplinary team led by John Varga, MD, John and Nancy Hughes Distinguished Professor of Rheumatology at Northwestern University Feinberg School of Medicine, was recently published in the journal Arthritis & Rheumatism.

"We showed, for the first time, that the Wnt signaling pathway is abnormally activated in scleroderma patients," said Varga, who is also a physician at Northwestern Memorial Hospital. "This is significant for three reasons. First, it gives a better picture of scleroderma and fibrosis in general. Second, it provides a strategy for assessing disease severity, progression, and activity. And third, it opens a door for the design of treatments that aim to block the Wnt pathway and restore its normal controlled activity."

Varga's laboratory collaborated with a pulmonary team at Northwestern, along with teams at Case Western Reserve University and Dartmouth University on the discovery.

Researchers studied skin and lung biopsies from scleroderma patients and found that the Wnt pathway was 'turned on', in contrast to healthy individuals where the pathway was 'turned off.' Varga said this activation may be due to loss of Wnt inhibitors that normally serve as 'brakes' on the pathway to prevent its activation.

The team also examined what the pathway does using fibroblasts and stem cells from healthy people. They found Wnt causes fibroblast activation and blocks the development of fat cells (adipocytes), which directly contribute to scar formation and tissue damage seen in scleroderma.

Scleroderma is a chronic autoimmune disease in which the body's immune system attacks itself. It causes progressive thickening and tightening (fibrosis) of the skin and also can lead to serious internal organ dam
'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic research develops tools for studying diseases, improving regenerative treatment
2. First complete full genetic map of promising energy crop
3. Genetic variation in East Asians found to explain resistance to cancer drugs
4. Epigenetics and epidemiology -- hip, hype and science
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Genetic survey of endangered Antarctic blue whales shows surprising diversity
7. A foot in the door to genetic information
8. Perception and preference may have genetic link to obesity
9. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
10. Will a genetic mutation cause trouble? Ask Spliceman
11. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... , May 22, 2015 According ... by Solution (2D, 3D, Thermal, Emotion, Forensic), by Software (Middleware, ... (Government and Utilities, Consumer and Home) - Global Forecast ... grow from $2.77 Billion in 2015 to $6.19 Billion ... Browse 79 market data Tables and   43 ...
(Date:5/19/2015)... , May 18, 2015 Fingerprint ... sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if ... June until and including Q3 2015 and the sensors will ... . Communicated order values for 2015 hereby amount to 740 ... Q1 2015 of 140 MSEK and a number of smaller ...
(Date:5/14/2015)... May 14, 2015  Verificient Technologies, Inc., ... and online remote proctoring, announced a new ... company and creator of the Canvas Learning ... two companies will benefit from the seamless ... As a fully integrated multifactor biometrics ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2
... Society (WCS) found that the black bears that become habituated ... behaviors exclusively from their mothers, as widely assumed. Bears that ... these habits on their own or pick them up from ... role of genetic relatedness in black bear behavior that leads ...
... AMES, Iowa -- Research led by Iowa State University limnologist, ... globe could absorb as much carbon as the world,s oceans. ... on farmland in the United States bury carbon at a ... the rate at which trees trap carbon. In addition, ponds ...
... New Version of PocketCop Software, WALL, N.J., ... BKYI), a leader in finger-based biometric,identification and wireless ... showcasing its latest mobile data solution for BlackBerry(R),smartphones ... Conference, to be held May 7-9 at the ...
Cached Biology News:When bears steal human food, mom's not to blame 2Ponds found to take up carbon like world's oceans 2BIO-key(R) Showcasing Public Safety Solutions for BlackBerry Smartphones at 2008 LEIM Conference 2BIO-key(R) Showcasing Public Safety Solutions for BlackBerry Smartphones at 2008 LEIM Conference 3
(Date:5/26/2015)... Oramed Pharmaceuticals Inc. (NASDAQ: ... focused on the development of oral drug delivery systems, ... for the company,s Phase IIb trial of ORMD-0801, its ... Administration (FDA). The submission was made under the company,s ... Phase IIb study of ORMD-0801 for type 2 diabetics ...
(Date:5/26/2015)... Bruno, CA (PRWEB) May 26, 2015 ... is officially joining the Alliance for Regenerative Medicine ... organizations, fostering research, development, investment, and commercialization of ... PRC Clinical, the California-based CRO focused ... expertise in stem cell and regenerative research working ...
(Date:5/25/2015)... (PRWEB) May 25, 2015 The ... Chloride Industry is a professional and in-depth study ... Hydrogen Chloride Market with a focus on ... hydrogen chloride market research are Linde Industrial Gas, ... Yuanhua Chemical, Shandong Xinlong Group, Longsheng Group, Juhua ...
(Date:5/22/2015)... Charm Sciences, Inc. is pleased to ... Grain Inspection, Packers and Stockyards Administration (GIPSA) has ... to monitor aflatoxin in grains utilizing Charm’s ROSA ... Aflatoxin Quantitative Test (solvent-based). , The Charm ... Extraction Technology to extract aflatoxin from the sample ...
Breaking Biology Technology:Oramed Submits Protocol to U.S. FDA for Its Phase IIb Oral Insulin Study 2Oramed Submits Protocol to U.S. FDA for Its Phase IIb Oral Insulin Study 3PRC Clinical Joins 200+ Member Organizations in The Alliance for Regenerative Medicine (ARM) 2PRC Clinical Joins 200+ Member Organizations in The Alliance for Regenerative Medicine (ARM) 3Global Hydrogen Chloride Industry 2015 Trends and Analysis Available in a New Report at DeepResearchReports.com 2Global Hydrogen Chloride Industry 2015 Trends and Analysis Available in a New Report at DeepResearchReports.com 3USDA-GIPSA (FGIS) Awards 5 Year Contract for Aflatoxin Tests to Charm Sciences 2
... ... Small-Scale Farmer Productivity , ... Milan, Italy (Vocus) Nov. 12, 2009 – Tackling global food security requires an ... on a local, national and international scale, DuPont Vice President and Pioneer Hi-Bred Chairman ...
... PLEASANTON, Calif., Nov. 12 Microchip Biotechnologies, Inc. (MBI), ... preparation and analysis, today announced an $18.1M close of ... commercialization of the Apollo 100 System, a sample preparation ... of the Apollo platform for the rapidly growing Next-Generation ...
... ... answers (Q&A) site that provides members the opportunity to ask and answer ... many science categories. Members can also enter a social media environment, where ... to multiple members. This environment also provides a place for members to ...
Cached Biology Technology:Start Locally, Collaborate to Increase Food Security, Says DuPont Leader to U.N. Group 2Start Locally, Collaborate to Increase Food Security, Says DuPont Leader to U.N. Group 3Start Locally, Collaborate to Increase Food Security, Says DuPont Leader to U.N. Group 4Microchip Biotechnologies Raises $18.1M in Series B Financing 2SciScout LLC Launches SciAnswers.com, a Science-Based Questions and Answers (Q&A) Site with a Social Networking Perspective. 2SciScout LLC Launches SciAnswers.com, a Science-Based Questions and Answers (Q&A) Site with a Social Networking Perspective. 3SciScout LLC Launches SciAnswers.com, a Science-Based Questions and Answers (Q&A) Site with a Social Networking Perspective. 4
Bag-1 (K-20)...
... 4 deuterium atoms at the 3, 3', ... for use as an internal standard for ... GC- or LC-mass spectrometry. PGE2 is one ... acid and one of the most widely ...
Deletions, insertions or substitutions. Mutations in plasmids of size up to 15 kb. Single or multiple mutations...
Request Info...
Biology Products: