Navigation Links
New genetic path for scleroderma
Date:3/19/2012

CHICAGO --- A genetic pathway previously known for its role in embryonic development and cancer has been identified as a target for systemic sclerosis, or scleroderma, therapy. The finding, discovered by a cross-disciplinary team led by John Varga, MD, John and Nancy Hughes Distinguished Professor of Rheumatology at Northwestern University Feinberg School of Medicine, was recently published in the journal Arthritis & Rheumatism.

"We showed, for the first time, that the Wnt signaling pathway is abnormally activated in scleroderma patients," said Varga, who is also a physician at Northwestern Memorial Hospital. "This is significant for three reasons. First, it gives a better picture of scleroderma and fibrosis in general. Second, it provides a strategy for assessing disease severity, progression, and activity. And third, it opens a door for the design of treatments that aim to block the Wnt pathway and restore its normal controlled activity."

Varga's laboratory collaborated with a pulmonary team at Northwestern, along with teams at Case Western Reserve University and Dartmouth University on the discovery.

Researchers studied skin and lung biopsies from scleroderma patients and found that the Wnt pathway was 'turned on', in contrast to healthy individuals where the pathway was 'turned off.' Varga said this activation may be due to loss of Wnt inhibitors that normally serve as 'brakes' on the pathway to prevent its activation.

The team also examined what the pathway does using fibroblasts and stem cells from healthy people. They found Wnt causes fibroblast activation and blocks the development of fat cells (adipocytes), which directly contribute to scar formation and tissue damage seen in scleroderma.

Scleroderma is a chronic autoimmune disease in which the body's immune system attacks itself. It causes progressive thickening and tightening (fibrosis) of the skin and also can lead to serious internal organ dam
'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic research develops tools for studying diseases, improving regenerative treatment
2. First complete full genetic map of promising energy crop
3. Genetic variation in East Asians found to explain resistance to cancer drugs
4. Epigenetics and epidemiology -- hip, hype and science
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Genetic survey of endangered Antarctic blue whales shows surprising diversity
7. A foot in the door to genetic information
8. Perception and preference may have genetic link to obesity
9. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
10. Will a genetic mutation cause trouble? Ask Spliceman
11. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), is ... the State of Washington,s Department of ... enrollment and central issuance system for driver,s licenses and identification ... project planning and development will start in January 2015, with ...
(Date:1/22/2015)... Technology Showcase, Hall E -   EyeLock Inc. , a ... will showcase its EyeLock ID technology integrated in a 3D ... Oak Ridge National Laboratory (ORNL) at the 2015 ... authentication technology is being used to validate the driver and ...
(Date:1/22/2015)... , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... commerce market, reports on the recent success of the Wocket™ smart wallet ... Wocket smart wallet was named as one of the "11 Hot ... "5 Best Products Launched At CES So Far" by Newseveryday.com and "The ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... much easier and faster using a powerful new gene-networking ... at Austin. Edward Marcotte and his colleague, postdoctoral ... identify new genes that regulate life span and are ... In collaboration with Andrew Frasers group at The ...
... anthrax spores were mailed to several news media offices ... 17 others. Clearing the Senate office building of the ... to the Government Accountability Office. Cleaning the Brentwood postal ... months. Researchers at the Georgia Tech Research ...
... improvement show: in the before photos, the surroundings are ... spaces to grab a meal, start a family and relax ... that the potential new homeowner is a lizard and the ... but instead from a herd of elephants. An ...
Cached Biology News:Gene discovery made easier with powerful new networking technique 2New decontamination system kills anthrax rapidly without lingering effects 2New decontamination system kills anthrax rapidly without lingering effects 3New decontamination system kills anthrax rapidly without lingering effects 4Elephant engineers 2Elephant engineers 3
(Date:1/22/2015)... 2015 Crystal Diagnostics (CDx) Xpress System, a ... received AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. ... referred to as STEC or the “Big-6”) as well as ... (cfu) per 325 g of raw ground beef and raw ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a project managed ... legal requirements around using controlled substances in pharmaceutical research, ... their international operations expand and become increasingly complex, large ... a result of the first phase of the CSCS ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, Inc., ... Inc. (NASDAQ: SQNM ), the leading ... for next generation noninvasive prenatal tests (NIPT). Through ... technology, called Mantis™, to advance analysis of clinically-relevant ...
(Date:12/25/2014)... report “Service Quality Management and Telco Customer Experience Management ... Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and segments ... revenues. , Browse 152 market data tables, 19 ... “Service Quality Management (SQM) and Telco Customer Experience Management ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... Berbee Information Networks Corporation ... IP communications partner of the year for 2005. ... satisfaction related to Berbee's sales and support of ... Berbee's Cisco practice, said it's the firm's fifth ...
... in downtown Madison and you could try out the city's ... on Wednesday. , ,An initial coverage area of 10 ... is operational and available for testing. And until April 1, ... Internet service providers will be selling service for monthly rates. ...
... Although more than 100 people have been infected with the ... poultry, the fact that the virus does not spread easily ... a biomedical puzzle. , ,Now, a study of cells in ... the cells of the system that makes it difficult for ...
Cached Biology Technology:Wireless advances in Madison, heats up in Waukesha 2UW shows why avian flu hasn't spread among humans yet 2UW shows why avian flu hasn't spread among humans yet 3
... Corning single use spatulas have been ... samples. They are for those interested in ... reusable spatulas. Each spatula is individually packaged, ... CLS number is a new product number, ...
... The LV Series offers high performance ... 14, 17, 23, and 34 frame sizes. ... perfect for life science applications, including medical ... other miniature automation systems., Meets a ...
... kit for a single fragment based screening project: , ... , 96 shape-diverse mixtures of 4 (5 ... files for structure refinement , Individual compounds ... are at ca. 50 mM. Supplied in 5 96-well trays. ...
... the proven features of the pET, BacVector ... all of the benefits and versatility of ... The pTriEx vectors have been extensively tested ... all three expression systems. In each case, ...
Biology Products: