Navigation Links
New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
Date:1/4/2009

PITTSBURGH, Jan. 4 An international team led by University of Pittsburgh School of Medicine researchers has identified genetic markers associated with risk for ulcerative colitis. The findings, which appear today as an advance online publication of the journal Nature Genetics, bring researchers closer to understanding the biological pathways involved in the disease and may lead to the development of new treatments that specifically target them.

Ulcerative colitis is a chronic, relapsing disorder that causes inflammation and ulceration in the inner lining of the rectum and large intestine. The most common symptoms are diarrhea (oftentimes bloody) and abdominal pain. Ulcerative colitis and Crohn's disease, another chronic gastrointestinal inflammatory disorder, are the two major forms of inflammatory bowel disease (IBD).

"Ulcerative colitis and Crohn's disease are chronic conditions that impact the day-to-day lives of patients," said senior author of the study Richard H. Duerr, M.D., associate professor of medicine and human genetics at the University of Pittsburgh School of Medicine and Graduate School of Public Health. "IBD is most often diagnosed in the teenage years or early adulthood. While patients usually don't die from IBD, affected individuals live with its debilitating symptoms during the most productive years of their lives."

Because IBD tends to run in families, researchers have long thought that genetic factors play a role. Technology developed in recent years has enabled systematic, genome-wide searches for gene markers associated with common human diseases, and the discovery of more than 30 genetic risk factors for Crohn's disease has been one of the major success stories in this new era of research. While some genetic factors associated with Crohn's disease also predispose individuals to ulcerative colitis, markers specific for ulcerative colitis had yet to be found. To do so, researchers performed a genome-wi
'/>"/>

Contact: Courtney McCrimmon
McCrimmonCP@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related biology news :

1. Genetic variation may lead to early cardiovascular disease
2. Scientists make strides toward defining genetic signature of Alzheimers disease
3. Safe new therapy for genetic heart disease
4. NIST guides genetic genealogy labs toward improved accuracy
5. Ancient African exodus mostly involved men, geneticists find
6. VCU survey: US public supports genetic research, testing and government spending on research
7. Attitudes towards assisted reproduction and preimplantation genetic diagnosis
8. MU researcher identifies possible genetic causes of borderline personality disorder
9. CSHL researchers map changing epigenetic modifications that enable transposons to run amok
10. Irritable bowel syndrome can have genetic causes
11. New research shows how gene function drives natural selection in important class of genetic elements

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2009)...t keep weakened and flabby arteries from collapsin..., those stents are no longer needed -- once the ar...Previously, doctors had no choice but to leave the... University,s Department of Biomedical Engineering... that carries drugs where they,re needed, then dis...
(Date:11/24/2009)...UGE Antarctica has long held secrets of the earth...ently, there has been very little information on t...s of ice for millions of years. Now, a team of res...ve been funded to the tune of $10 million dollars ... to the bottom of things literally. These scienti...
(Date:11/23/2009)...New research presents strong evidence that the "sy...utdoor traffic-related pollution and indoor endoto...or the other exposure alone. , Environmental h...UC) College of Medicine have shown that children e...icles and indoor endotoxin during early life are s...
Breaking Biology News(10 mins):A coating for life 2LSU gets to the bottom of things -- in Antarctica 2Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later 2ICL Reports Continued Sequential Improvement for Third Quarter of 2009 62011 1ICL Reports Continued Sequential Improvement for Third Quarter of 2009 62011 2ICL Reports Continued Sequential Improvement for Third Quarter of 2009 62011 3ICL Reports Continued Sequential Improvement for Third Quarter of 2009 62011 4ICL Reports Continued Sequential Improvement for Third Quarter of 2009 62011 5ICL Reports Continued Sequential Improvement for Third Quarter of 2009 62011 6ICL Reports Continued Sequential Improvement for Third Quarter of 2009 62011 7Jackson 26amp 3B Coker Industry Report Addresses Health Care Reform 62010 1Jackson 26amp 3B Coker Industry Report Addresses Health Care Reform 62010 2Jackson 26amp 3B Coker Industry Report Addresses Health Care Reform 62010 3Slate Capital Group and New Markets Venture Partners Acquire eCoast Sales Solutions 62008 1Slate Capital Group and New Markets Venture Partners Acquire eCoast Sales Solutions 62008 2Slate Capital Group and New Markets Venture Partners Acquire eCoast Sales Solutions 62008 3
...AMBRIDGE, Mass. (April 2, 2009) Whitehead Institu...ifiable prion proteins in yeast and have further c...f both beneficial and detrimental traits. , "The ...al are they evolved to be prions, or are they alw...," says Randal Halfmann, a research assistant in W...
...New diseases directly affect human survival and fo...bs. Leaf-cutting ants, one of a few groups of soci...t material to fertilize their underground fungal g... Smithsonian show that both the ants and their fun...t inside leaves, thus ensuring the health of their...
...AMBRIDGE, Mass.--Each year, hundreds of thousands ...rmic needles that penetrate too far under their sk...lleagues aims to prevent this from happening by ke...urely mechanical, is based on concepts borrowed fr... needle containing a filament that acts as a guide...
Other Biology News:Redefining what it means to be a prion 2Redefining what it means to be a prion 3Food security for leaf-cutting ants: Workers and their fungus garden reject endophyte invaders 2MIT: Novel needle could cut medical complications 2
(Date:11/25/2009)... , NEW YORK, Nov. 25 Reportl...ort is available in its catalogue: ,, Brazil B..., http://www.reportlinker.com/p0165503/Brazil-...tml ,, Brazil Bioethanol Market Analysis and F...provides detailed analysis and forecasts of the gl...
(Date:11/24/2009)... The New York investment bank KTA ...EU) has agreed an AU$6.7 mil convertible note priv...The private placement was arranged by KTA Capital ... , New York (PRWEB) Novem...t bank KTA Capital, LLC ("KTA Capital") ...
(Date:11/24/2009)... Health care employment grew by ...only one to show consistent growth during the U.S....ls remain in trouble, and health systems are comin...el, instead of just administrators. , ...are employment continued growing in October despit...
(Date:11/24/2009)...EATTLE,Nov.24/PRNewswire/--BlueMarbleEnergyCorp.an...pmentAuthority(OPDA)wererecentlyawarded$2millionby...ard(CERB)inaprivate/publicpartnershiptoconstructth...olnCounty,WA. ,, "Thisinvestmentwillsignificant...0greenjobstoLincolnCounty,"saidBlueMarbleEnergyCEO...
Breaking Biology Technology:Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 2Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 3Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 4Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 5Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 6Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 7Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 8Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 9Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 10KTA Capital Arranges an AU$6.7 Million Private Placement by Neuren Pharmaceuticals 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 4Blue Marble Energy, OPDA Awarded $2M by WA's Community Economic Revitalization Board 2
...lcers each year in the US, PRINCETON, N.J., March...), provider of advanced wound care products,announ... the clinical usage,of its newly released MEDIHONE...mum Honey presented at the annual American Profess...ld the second week in March in Forth,Worth, Texas,...
...aunch..., WAYLAND, Mass., March 20 Tourtellotte ...linical trials software, announces the,launch of i...rm for phase,II-IV studies. Trident,s unique param...of legacy IVRS technologies and promises to delive...nd ease-of-use to the straining,global clinical IV...
...nc., a,pioneer in drug discovery from marine micro...begun in a Phase 1b study evaluating the vascular,...h standard chemotherapy,in patients with non-small...ositive outcomes in a Phase 1 single-agent clinica...armacodynamics (PK/PD) and efficacy of NPI-2358,in...
Other Biology Technology:Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA 2Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA 3Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA 4Tourtellotte's New Trident IWR(TM) Eliminates 12-Week Study Setup Lead Time for Clinical Trials 2Tourtellotte's New Trident IWR(TM) Eliminates 12-Week Study Setup Lead Time for Clinical Trials 3Nereus Pharmaceuticals Initiates Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer Following Encouraging Phase 1 Data 2Nereus Pharmaceuticals Initiates Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer Following Encouraging Phase 1 Data 3
Chicken Anti-HOXC11 Polyclonal Antibody, Unconjugated from ProSci, Inc
Chicken Anti-HOXC11 Polyclonal Antibody, Unconjugated from ProSci, Inc
Goat Anti-NIR1 Polyclonal Antibody, Unconjugated from Abcam
Rabbit Anti-NeuroD 6 Antibody, Unconjugated from CHEMICON
Biology Products: