Navigation Links
New genetic link found between normal fetal growth and cancer
Date:4/8/2013

Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers.

The work, conducted using mouse and human tissue, appears in today's issue of the Proceedings of the National Academy of Sciences. The authors, Julian C. Lui, Ph.D., and Jeffrey Baron, M.D., work at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

"We've long known that some of the genes that promote rapid growth in prenatal and early postnatal life become reactivated in cancer cells," said Dr. Baron. "Now we've identified a molecular switch that appears to turn on some of these genes, taking us a step forward in understanding normal body growth and the abnormal growth in some types of cancer."

Before birth, a team of more than 200 growth-promoting genes is highly active, fueling the fetus' explosive growth. After birth, these genes are gradually switched off, apparently to slow body growth as we age and approach adult size. In cancer cells, some of these genes can be switched back on.

One of the major growth-promoting genes is called IGF2. This gene is critical for normal prenatal body growth and is reactivated in many types of cancer, showing remarkably high activity in bladder and prostate cancer and some childhood cancers.

For years, scientists did not know what turned IGF2 on and off. Now, using a variety of techniques and tissue types, Drs. Lui and Baron found evidence that a protein known as E2F3 activates the IGF2 gene in normal development and in cancerin particular, in bladder and metastatic prostate cancers.

More broadly, E2F3 appears to regulate not just IGF2, but also many other genes on the body-growth team. When E2F3 levels are high, these genes are active. When E2F3 takes a dive, so do these genes. The upshot is that E2F3 may function as one of the master switches that limit body growth. As such, it is of great interest as researchers seek to understand the complex genetic choreography responsible for normal growth and the diseases that result when it goes awry.


'/>"/>

Contact: Alisa Machalek
alisa.machalek@nih.gov
NIH/National Institute of General Medical Sciences
Source:Eurekalert

Related biology news :

1. Couch potatoes may be genetically predisposed to being lazy, MU study finds
2. Symposium highlights epigenetic effects of milk
3. Genetics Society of Americas Genetics journal highlights for April 2013
4. Researchers discover brain cancer treatment using genetic material from bone marrow cells
5. Study finds strong genetic component to childhood obesity
6. Genetic alterations linked with bladder cancer risk, recurrence, progression, and patient survival
7. Genetic analysis saves major apple-producing region of Washington state
8. Epigenetics studies take root in plants
9. Genetic analysis calls for the protection of 2 highly endangered Portuguese fish species
10. New database to speed genetic discoveries
11. Researchers divide enzyme to conquer genetic puzzle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2017)... Pa. , March 20, 2017 PMD ... 2.0 personal spirometer and Wellness Management System (WMS), a ... Founded in 2010, PMD Healthcare is a Medical ... with a mission dedicated to creating innovative solutions that ... life. With that intent focus, PMD developed the first ...
(Date:3/13/2017)... 13, 2017 Future of security: Biometric Face Matching software  ... ... DERMALOGs Face Matching enables to match face pictures against each other ... identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face Matching on the ...
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. , March ... Made Simple," and 23andMe , the leading personal ... food choices.  Zipongo can now provide customers with personalized ... health goals and biometrics, but also genetic markers impacting ... Zipongo,s personalized food decision support platform uses ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... May 16, 2017 , ... Clinical Supplies Management (“CSM”), a Great Point Partners ... to grow. CSM has doubled in size over the past six months with ... strategy. , Roger Gasper joins CSM as Chief Financial Officer. Roger has over ...
(Date:5/18/2017)... BARBARA, CALIFORNIA (PRWEB) , ... May 17, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... Chairman of the UDIs and Traceability for Medical Devices conference in Brussels, Belgium. ...
(Date:5/18/2017)... ... ... was notified earlier this year that his company Asymmetrex had been selected as ... Review , he was not surprised as others might be. Sherley says, “I felt ... Valley was particularly meaningful. Our selection by The Silicon Review may seem ...
(Date:5/16/2017)... ... May 16, 2017 , ... Cynvenio Biosystems, Inc. ... Lung Cancer blood test. Leveraging a highly-sensitive next-generation sequencing panel of 11 genes ... quickly and accurately identify tumor-related genetic mutations that can be treated with targeted ...
Breaking Biology Technology: