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New genetic discovery could reduce the guesswork in drug dosing

in deeper and often overlooked regions of genes. Sadee has designed a technique to determine variant functions based on measurements of how much messenger RNA (mRNA), a carrier of genetic information, each specific allele expresses an activity that occurs before amino acids are assembled.

"We're finding now that in 90 percent of cases, it would appear that the SNP working at the protein level is not the one that affects function instead it's the SNP that affects mRNA expression," Sadee said. "It turns out SNPs in the middle of nowhere in regions formerly called junk DNA are actually in the middle of something."


Contact: Wolfgang Sadee
Ohio State University

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