Navigation Links
New genetic discovery could reduce the guesswork in drug dosing
Date:10/1/2013

ndividual is a poor or ultra-rapid metabolizer. The SNPs we found will more precisely predict whether an individual is in the ultra-rapid or intermediate metabolic range," Wang said. "The poor metabolizers are well-defined by the current panel with variants with no enzyme activity at all."

A poor metabolizer is likely to experience high toxicity from medications processed by this enzyme, or get minimal or no benefit at all if a drug such as codeine needs to be activated by it. Ultra-rapid metabolizers, on the other hand, may not benefit from drugs processed by the enzyme or suffer adverse reactions from drugs that need it for activation. Metabolizer status has pronounced effects on treatment outcomes and cost of therapy.

"If you could give a drug and get an immediate response, then that in itself would be a marker for the drug's effect. But there is no immediate response for many drugs," Sadee said. "Having a pharmacogenomics marker test that's viable and useful could predict when caution is needed in prescribing drugs."

In the case of antidepressants or antipsychotics, for example, with delayed clinical effect, an ultra-rapid metabolizer would have to take the drug for weeks before finding out that a drug isn't having any effect, while a poor metabolizer is likely to have toxic side effects. And with codeine, which is converted into morphine in the body, an ultra-rapid metabolizer could inadvertently overdose on morphine by taking too much codeine.

The Ohio State pharmacogenomics group is among the few in the world pursuing hard-to-find genetic variants that significantly alter biological functions. For the past 30 years, scientists studying genetic variants have focused on genetic variants that change enzyme function by altering the encoded amino acid sequence.

Sadee's lab, however, focuses on variants that are harder to detect and analyze because they have no direct role in determining the protein sequence; they exist
'/>"/>

Contact: Wolfgang Sadee
wolfgang.sadee@osumc.edu
614-292-1597
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
2. Will a genetic mutation cause trouble? Ask Spliceman
3. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
4. Perception and preference may have genetic link to obesity
5. A foot in the door to genetic information
6. Genetic survey of endangered Antarctic blue whales shows surprising diversity
7. Epigenetic signatures direct the repair potential of reprogrammed cells
8. Epigenetics and epidemiology -- hip, hype and science
9. Genetic variation in East Asians found to explain resistance to cancer drugs
10. First complete full genetic map of promising energy crop
11. Genetic research develops tools for studying diseases, improving regenerative treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... patients, scientists have identified more than two dozen ... six that had not been previously reported. The ... partially funded by the National Institutes of Health ... laboratories. , "Unraveling the genetic underpinnings of Parkinson,s ... in this complex disease, and hopefully, may one ...
(Date:7/25/2014)... on the land now called California, and many of ... plants they used for food, fuel, tools, and ritual. ... habitat and natural resources. , Frank Lake, an ecologist ... lead a field trip to the Stone ... America,s 99th Annual Meeting, in Sacramento, Cal. this August. ...
(Date:7/25/2014)... wildfires have been raging this summer and some of the ... In this image collected by the Moderate Resolution Imaging ... a swath of smoke has descended over the Great Lakes ... is the fire image from July 23, 2014 (first image ... as it drifts off southeastward. In the image, it ...
Breaking Biology News(10 mins):NIH scientists find 6 new genetic risk factors for Parkinson's 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... a mystery with a stubby tail: an odd-looking mouse discovered through ... short, kinky tail and an extra set of ribs in its ... led by researchers at the University of California, San Francisco has ... so, they may have uncovered a new wrinkle in the genetic ...
... Stronger and tougher body armor to shield the chest, ... the Afghanistan and Iraq wars need to better protect their ... of a Johns Hopkins study in mice suggest. Such ... grenades and improvised explosive devices (IEDs) now accounts for more ...
... big effect on their life. Some people are outgoing ... can be detrimental to their health and wellbeing. Increasingly, ... , A new study led by Dr Kathryn Arnold, ... has added important experimental evidence showing that animal personalities ...
Cached Biology News:Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists 2Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists 3Shielding body protects brain from 'shell shocking' blast injuries 2Shielding body protects brain from 'shell shocking' blast injuries 3Animals have personalities, too 2
(Date:7/28/2014)... July 28, 2014 Appistry, Inc. ... that bring the power of genomics to next-generation medicine, ... Appistry Pipeline Challenge . , Two Appistry staff ... the National Center for Genome Resources, and Mr. Neil ... Clinics of Kansas City. Rounding out the panel are ...
(Date:7/28/2014)... The global market for biotechnology is expected ... a new study by Grand View Research, Inc. Increasing ... vaccines and drugs in an attempt to improve healthcare ... to drive market demand over the next six years. ... the use of genetically engineered seeds is expected to ...
(Date:7/28/2014)... COLLEGE STATION, Texas , July 28, 2014   The ... be a 177-key, 4-star boutique hotel in the heart of The ... Texas.  Photo - http://photos.prnewswire.com/prnh/20140725/130455 ... hotel within ATLAS , The ... standard rooms and suites, a sleek restaurant and bar, a wellness ...
(Date:7/28/2014)... IN (PRWEB) July 28, 2014 The ... Center, in Muncie IN, is pleased to announce that ... the National Museum of the United States Air Force. ... a year-long process that concluded this spring with an ... the Dayton, OH museum. , The National Museum ...
Breaking Biology Technology:Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2
... two new papers, Rice University researchers report using ultracentrifugation ... species. One team, led by Rice Professor Junichiro ... has made a small but significant step toward the ... on highly conductive quantum nanowire. The other, led ...
... , , ... Corp. (TSX:RVX) announced today that it will host a live teleconference and ... Eastern/ 11:00 am Mountain time . The purpose of the teleconference ... slide presentation followed by a question and answer session regarding the impact ...
... GUANGZHOU, China , May 10 /PRNewswire-Asia/ -- China Medicine Corporation,(OTC ... of Western pharmaceuticals, traditional Chinese medicine,products, other nutraceuticals, medical devices, and ... 9:00 a.m. Eastern,Time on Thursday, May 13, 2010 to ... , , ...
Cached Biology Technology:Nano parfait a treat for scientists 2Nano parfait a treat for scientists 3Resverlogix Notice of Conference Call & Webcast for Year End Update 2China Medicine Announces Conference Call to Discuss First Quarter 2010 Results 2
Normal serum collected from healthy Kunming mice....
Request Info...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
QML offers standard and customized paraffin embedded tissue blocks....
Biology Products: