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New genetic cause of cardiac failure discovered
Date:11/25/2009

llman Dahme, resident and co-author of the study. The researchers examined the genetic material of affected patients and verified a mutated Z-disk protein in 9 of 1000 participants. They showed that in these patients, the defective nexilin was the major cause of heart disease. "The nexilin dilated cardiomyopathy allowed us for the first time to describe a new form of heart muscle dilatation and define the mechanism causing it, namely destabilization of the Z-disk," says Dahme.

The studies also showed that the extent of the damage to the Z-disk is directly related to the workload. This insight has an influence on clinical therapy. "Patients with a nexilin mutation might benefit from early treatment with medications that reduce cardiac stress. This could lower the mechanical stress on the Z-disks and prevent progressive damage to the heart," said Dr. Rottbauer.


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Contact: Dr. Wolfgang Rottbauer
wolfgang.rottbauer@med.uni-heidelberg.de
49-622-1563-8851
University Hospital Heidelberg
Source:Eurekalert  

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