Navigation Links
New 'genetic bar code' technique establishes ability to derive DNA information from RNA
Date:4/8/2012

reater good of medical science.

In the Nature Genetics study, Drs. Schadt and Hao, Associate Professor of Genetics at Mount Sinai School of Medicine, together with Sangsoon Woo, PhD, from the Department of Biostatistics at the University of Washington, analyzed RNA and DNA from 378 livers donated by European-Americans for transplant, as well as liver and adipose tissues from 580 people from the same population group undergoing gastric bypass surgery. The authors found that levels of RNA across many genes correlate with age, sex, body weight, and other risk factors for diseases like diabetes and heart disease, but then they also correlate in many cases with changes in DNA that are unique to a given individual.

The investigators used an algorithm that matches patterns of gene expression to variations at 1,000 single-DNA-base sites in the genome. It is an application of integrative biology that examines multiple dimensions of data (DNA and RNA) to better inform a given dimension (RNA).

"The relationship of DNA to RNA is like that of an orchestra and the symphony it plays," said Schadt describing the new technique. "The DNA (orchestra) remains the same, while the RNA pattern (quality of the music) changes in response to outside factors. The new technique is like hearing a symphony and deducing which instruments are in the orchestra, essentially unwinding the developmental process to trace tissue samples back to RNA and the gene that instructed it."


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New lab mice cut search for genetic links to disease by more than a decade
2. Genzyme/ACMG Foundation Genetics Training Award in Clinical Biochemical Genetics announced
3. Renowned geneticist R. Rodney Howell receives ACMG Foundation Lifetime Achievement Award
4. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
5. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
6. Researcher who identifed genetic cause and possible treatment for Marfan syndrome honored
7. Genetic abnormality offers diagnostic hope for childrens cancer
8. U-M Health and Retirement Study adds genetic data to NIH database
9. Researchers unravel genetic mechanism of fatty liver disease in obese children
10. Genetic mutation found in familial chronic diarrhea syndrome
11. New genetic path for scleroderma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... held in New York City on September 19, 2014, ... Cancer Society Professor of Genome Sciences and Medicine at ... Doctor of Philosophy of Tel Aviv University, was awarded ... , In addition to her honorary degree from TAU, ... TAU School of Medicine, and for the past 18 ...
(Date:10/29/2014)... is available in German . ... Gabriela Cabral and Peter Schlögelhofer at the Max F. ... the Medical University of Vienna dived into the process ... these plants display an inversion of the standard meiotic ... scientific journal Nature Communications . , Meiosis is ...
(Date:10/29/2014)... of the Barcode of Life Data Systems ... Biodiversity Data Journal (BDJ) used specimen records ... into a human-readable text developed in manuscript within the ... to study the species distributions of ten Nearctic species ... is originally designed to support the generation and application ...
Breaking Biology News(10 mins):Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2Meiotic cell division 'the other way round' 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2
... is a key requirement for good health and alternative cheap, ... that has just been published in the leading American Chemical ... University in co-operation with The University of Botswana describe how ... used for water purification. Flocculation of particulate impurities ...
... A rapid and unprecedented proliferation of oil and gas ... area leased is on track to reach around 70% ... is one of the central conclusions from a pair ... Ambientals (ICTA) of Universitat Autnoma de Barcelona (UAB), and ...
... for the Advancement of Science (AAAS) meeting is being ... will be presenting on topics ranging from linear colliders ... Also occurring at the end of this year,s ... as the next president of the AAAS. Below is ...
Cached Biology News:Seeds from the Moringa tree can be used for water purification 2A second hydrocarbon boom threatens the Peruvian Amazon 2A second hydrocarbon boom threatens the Peruvian Amazon 3Caltech researchers presenting at AAAS Meeting 2Caltech researchers presenting at AAAS Meeting 3Caltech researchers presenting at AAAS Meeting 4Caltech researchers presenting at AAAS Meeting 5Caltech researchers presenting at AAAS Meeting 6
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industry” is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
(Date:10/30/2014)... Spartan Bioscience announced today that Health Canada has ... detects CYP2C19 genetic mutations in less than 60 minutes ... CYP2C19 System is the first near-patient DNA test for ... to the system’s ease of use, Health Canada has ... such as doctors, nurses, pharmacists, and laboratory technicians, in ...
(Date:10/30/2014)... Oct. 30, 2014 A new report, commissioned ... Practice, takes an in-depth look at Indiana,s ... have resulted over two different time frames: 1993 to ... view of future opportunities for investment growth.  The ... report shows gains in innovation dollars as well ...
(Date:10/27/2014)... (PRWEB) October 27, 2014 The ... by Type (High & Medium), Sub-type (Primary & ... Processing, Infrastructure & Transportation & Power Generation) - ... the GIS market with analysis and forecasting of ... Market Data Tables with 52 Figures spread through ...
Breaking Biology Technology:Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4
... Prize, Draper Laboratory, in conjunction with the National Academy of Engineering ... learn about the impact engineers have had on our daily lives, ... been awarded "Engineering,s Nobel" since 1989. , ... Cambridge, ...
... Inc.,(Nasdaq: PCYC ), a developmental stage biopharmaceutical ... late stage preclinical programs,announced today the appointment of a ... Robert W. Duggan, our Chairman of ... acting as interim CEO for the past five months. ...
... Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ) today ... position of Vice President, Chief Financial Officer & Treasurer. ... terminated as Savient,s Chief Financial Officer, effective immediately. ... our current Vice President of Corporate Finance and Controller, ...
Cached Biology Technology:New Educational Website Celebrates the Accomplishments of Engineers 2Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 2Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 3Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 4Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 5Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 6Savient Announces Appointment of David Gionco as Chief Financial Officer 2Savient Announces Appointment of David Gionco as Chief Financial Officer 3Savient Announces Appointment of David Gionco as Chief Financial Officer 4
... Buffer is a concentrated formulation of a ... capillary action technology, as well as for ... with David Brigati M.D., Department of Pathology, ... buffer is recommended for all the rinsing ...
...
... Intended for users requiring mass detection ... linear MALDI TOF Mass spectrometer is ... applications and for high performance mass ... QA/QC, SNP analysis, protein detection, micro-satellite ...
Rat Aortic Smooth Muscle Cells (RAOSMC) (>500,000 cells)...
Biology Products: