Navigation Links
New 'genetic bar code' technique establishes ability to derive DNA information from RNA
Date:4/8/2012

Researchers from Mount Sinai School of Medicine have developed a method to derive enough DNA information from non-DNA sourcessuch as RNAto clearly identify individuals whose biological data are stored in massive research repositories. The approach may raise questions regarding the ability to protect individual identity when high-dimensional data are collected for research purposes. A paper introducing the technique appears in the April 8 online edition of Nature Genetics.

DNA contains the genetic instructions used in the development and functioning of every living cell. RNA acts as a messenger that relays genetic information in the cell so that the great majority of processes needed for tissue to function properly can be carried out.

To date, access to data bases with DNA information has been restricted and protected as it has long been considered the sole genetic fingerprint for every individual. However, vast amounts of RNA data have been made publicly available via a number of databases in the United States and Europe. These databases contain thousands of genomic studies from around the world.

In this study, lead authors Eric E. Schadt, PhD, and Ke Hao, PhD, developed a technique whereby a person's DNA could be inferred from RNA data using gene-expression levels monitored in any of a number of tissues. In contrast, most studies involving DNA and RNA begin with DNA sequences and then seek to associate expression patterns with changes in DNA between individuals in a population. This is the first time going from RNA levels to DNA sequence has been described.

"By observing RNA levels in a given tissue, we can infer a genotypic barcode that uniquely tags an individual in ways that enables matching the individual to an independently derived DNA sample," said Dr. Schadt, Director of the Institute for Genomics and Multiscale Biology, the Jean C. and James W. Crystal Professor of Genomics, and Chair of the Department of Ge
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New lab mice cut search for genetic links to disease by more than a decade
2. Genzyme/ACMG Foundation Genetics Training Award in Clinical Biochemical Genetics announced
3. Renowned geneticist R. Rodney Howell receives ACMG Foundation Lifetime Achievement Award
4. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
5. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
6. Researcher who identifed genetic cause and possible treatment for Marfan syndrome honored
7. Genetic abnormality offers diagnostic hope for childrens cancer
8. U-M Health and Retirement Study adds genetic data to NIH database
9. Researchers unravel genetic mechanism of fatty liver disease in obese children
10. Genetic mutation found in familial chronic diarrhea syndrome
11. New genetic path for scleroderma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Roald Amundsen became the first man to reach the ... years later, an international team of scientists led by ... proven that air pollution from industrial activities arrived long ... from widely spaced locations around the Antarctic continent, including ... and precise reconstruction to date of lead pollution over ...
(Date:7/27/2014)... asteroid strike that wiped them out if it had ... say. , A fresh study using up-to-date fossil records ... a new narrative of the prehistoric creatures, demise, some ... the few million years before a 10km-wide asteroid struck ... This included extensive volcanic activity, changing sea levels and ...
(Date:7/27/2014)... discovered a new species of mayfly in the southern Western ... In fact, this is the first time that any mayfly ... in peninsular India. , The new species, called Labiobaetis ... for his substantial contribution to the understanding of the Ephemeroptera ... a study that describes the new mayfly in the ...
Breaking Biology News(10 mins):Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3Dinosaurs fell victim to perfect storm of events, study shows 2
... by researchers at Baylor College of Medicine (BCM) and ... DNA sequencing to the patient's bedside, the doctor's office ... battlefield. , "We could eventually do direct detection of ... performed in the laboratory, said Dr. Michael L. Metzker, ...
... in the March 30th edition of the prestigious scientific journal ... UK's national academy of science) shows that the transfer of ... is much larger and more extensive than previously believed. , ... in a contentious debate. It is the first to isolate ...
... "A Method of Reconstituting Nucleic Acid Molecules" today to ... of DermaPlus, Inc. The patent covers methods for recovering ... allow scientists to reassemble everything from prehistoric, extinct animals ... applied by our scientists, brings us closer to our ...
Cached Biology News:Color-blind method opens new doors in DNA sequencing 2Color-blind method opens new doors in DNA sequencing 3Researchers reveal the infectious impact of salmon farms on wild salmon 2Researchers reveal the infectious impact of salmon farms on wild salmon 3Researchers reveal the infectious impact of salmon farms on wild salmon 4Dinosaur DNA? New Patent Covers Degraded DNA recovery 2
(Date:7/28/2014)... Reston, VA (PRWEB) July 28, 2014 ... leading nonprofit authority on the use of health IT ... its Health Plan Identifier (HPID) Workgroup has ... Between a Health Plan and Payer?” The HPID Workgroup, ... worked closely with the Centers for Medicare and Medicaid ...
(Date:7/28/2014)... 28, 2014 Research and Markets ... Biology Market 2014-2018" report to their offering. ... term synthetic biology covers the designing and engineering of ... as the redesigning of natural biological systems that provide ... a form of extreme genetic engineering because it not ...
(Date:7/28/2014)... Hershey, PA & Boston, MA (PRWEB) July 28, 2014 ... into collaboration agreements with two researchers to further develop ... and deadly malignant brain tumor, in combination with their ... executed by ITI and Duke University, are based on ... MHSc, Chief, Division of Neurosurgery at The Preston Robert ...
(Date:7/28/2014)... The global market for biotechnology is expected ... a new study by Grand View Research, Inc. Increasing ... vaccines and drugs in an attempt to improve healthcare ... to drive market demand over the next six years. ... the use of genetically engineered seeds is expected to ...
Breaking Biology Technology:WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2Global Synthetic Biology Market 2014-2018 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4
... March 14, 2011 Argentum Medical, LLC today issued a ... versus Noble Biomaterials, Inc. "The most important thing ... patents and it is business as usual for Argentum," said ... case concerned non-patent issues and is currently being appealed. We ...
... Biofuels, a bioenergy crop company using breeding and biotechnology ... it is applying more than 1.6 million genetic markers ... of marker assisted selection (MAS) methods to produce elite, ... the announcement during its presentation at the Biowise 2011 ...
... March 11, 2011 /PRNewswire-Asia-FirstCall/ --Tianyin Pharmaceutical Co., Inc. (NYSE ... specializes in patented biopharmaceutical medicine, modernized traditional Chinese medicine, ... at the 23rd ROTH Annual OC Growth Stock Conference ... Carlton in Dana Point, California. Dr. James ...
Cached Biology Technology:Argentum Medical Issues Response to Recent Decision in Litigation With Noble Biomaterials 2SG Biofuels Advances Jatropha Biotech Platform with Application of Genetic Markers to Reference Genome 2TPI Attends 23rd ROTH Annual OC Growth Stock Conference from March 13-16, 2011 2
Troponin I (22B11)...
... low temperature freezers offer a superior ... of biological samples with high capacities. ... inner doors ensure excellent warming protection ... ,Application oriented accessories simplify tracking of ...
Chicken polyclonal to UCK2 ( Abpromise for all tested applications). Antigen: Full length protein, corresponding to amino acids 1-261 of Human UCK2 Entrez Gene ID: 7371 Swiss Protein ID: ...
Thermo Labsystems offers a basic reader for 96-well microplates that is especially adapted for ELISA and other colorimetric assays....
Biology Products: