Navigation Links
New genes discovered for adult BMI levels
Date:10/25/2012

A large international study has identified three new gene variants associated with body mass index (BMI) levels in adults. The scientific consortium, numbering approximately 200 researchers, performed a meta-analysis of 46 studies, covering gene data from nearly 109,000 adults, spanning four ethnic groups.

In discovering intriguing links to lipid-related diseases, type 2 diabetes and other disorders, the IBC 50K SNP Array BMI Consortium's study may provide fundamental insights into the biology of adult obesity. Scientists from the Center for Applied Genomics at The Children's Hospital of Philadelphia led the study, using the CardioChip, a gene array containing probes for some 50,000 genetic variants across 2,100 genes relevant to cardiovascular and metabolic functions.

The study appeared online Sept. 21 in Human Molecular Genetics.

"BMI is a widely used measure of obesity, which affects one third of U.S. adults, and approximately half a billion people worldwide," said first author Yiran Guo, Ph.D., of Children's Hospital, who led the meta-analysis. "Previous studies have shown that genetics plays an important role in obesity, and this study expands our knowledge of BMI genetics."

The researchers first analyzed a dataset of approximately 51,000 individuals of European ancestry (EA) to discover initial gene signals, and then performed replication studies in another 27,000 EA subjects, as well as 14,500 additional EA individuals. Further analyses of data from approximately 12,300 African Americans, 2,600 Hispanics and 1,100 East Asians strengthened the team's findings.

The researchers uncovered three novel signals, from the genes TOMM40-APOE-APOC1, SREBF2 and NTRK2) that were significantly associated with BMI in adults. All had previously been linked to other important disorders. The APOE locus is well known to be involved in blood lipid regulation and circulation, and plays an important role in Alzheimer's disea
'/>"/>

Contact: Dana Mortensen
Mortensen@email.chop.edu
267-426-6092
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genes, depression and life satisfaction
2. Pollen cells keep memory to control jumping genes
3. A mother’s nutrition--before pregnancy--may alter the function of her children’s genes
4. Insecticide resistance caused by recombination of 2 genes
5. Protecting genes, one molecule at a time
6. Picky penguins: Does mate choice depend on genes that help resist disease?
7. Singapore scientists find genes associated with glaucoma, a major cause of eye blindness
8. GW professor receives grant to study the role of genes in drug addiction
9. CYCLOPS genes may serve as an Achilles heel in tumor cells
10. New key element discovered in pathogenesis of Burkitt lymphoma
11. Feces fossils yield new insights into ancient diets and thrifty genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... What motivates consumers to make ethical choices such as ... more money on fair-trade coffee, and bringing their own ... study in the Journal of Consumer Research , ... to turn their emotions about unethical practices into action. ... consider the environmental and human costs of the products ...
(Date:9/16/2014)... Ill. , Sept. 16, 2014 As ... to make important decisions about their 2015 benefits. According ... and health solutions business of Aon plc ... to take a more proactive role in managing their ... important than ever for individuals to understand how they ...
(Date:9/15/2014)... division has evolved a simple, mechanical solution to ... Sept. 11 Science Express. ... and misalignments that lead to infertility, miscarriage, or ... division cause these problems, but what exactly goes ... of the Wellcome Trust Center for Cell Biology ...
Breaking Biology News(10 mins):Why are consumers willing to spend more money on ethical products? 2Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 2Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 3Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 4Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 5Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 6Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 7Cells simply avoid chromosome confusion 2Cells simply avoid chromosome confusion 3
... is available in German . , ... of the extended cultivation of energy crops. Scientists have ... impacts and comparing the effectiveness of strategies for the ... of bioenergy leads to problems to biological diversity in ...
... The New York Botanical Garden (NYBG); the Missouri ... Kew); and the Royal Botanic Garden Edinburgh (RBGE) have ... online catalog of the world,s plantsby the year 2020. ... on up to 400,000 plant species worldwide. It will ...
... DIEGO ,Brain freeze, is a nearly universal experiencealmost everyone has ... ice cream or slurp of ice-cold soda on the upper ... this phenomenon. Since migraine sufferers are more likely to experience ... brain freeze may share a common mechanism with other types ...
Cached Biology News:How the ecological risks of extended bioenergy production can be reduced 2How the ecological risks of extended bioenergy production can be reduced 3Putting plants online: 4 leading botanical gardens to create first online catalog of all plants 2Putting plants online: 4 leading botanical gardens to create first online catalog of all plants 3Changes in brain's blood flow could cause 'brain freeze' 2Changes in brain's blood flow could cause 'brain freeze' 3
(Date:9/15/2014)... 2014  iVinci Health LLC, the company behind the ... system, branded as VisitPay®, has successfully closed $5 million ... of a new extension to VisitPay® – an online ... convenient way for patients to manage their medical bills ... and their families. The new round of ...
(Date:9/15/2014)... CA (PRWEB) September 15, 2014 ... term implantable silicones for the medical device and ... silicone gel for the implantable medical device market. ... unique crosslink technology delivering a silicone gel with ... The Dual Matrix technology consists of two crosslinked ...
(Date:9/15/2014)... ANNAPOLIS, Maryland , 15 de septiembre de 2014 /PRNewswire/ ... se llevará a cabo del 12 al 18 de ... Association (PPTA) y de sus compañías miembro s, ... de la concienciación mundial en torno a la colección de ... los donantes de plasma al salvar y mejorar las vidas ...
(Date:9/14/2014)... MD (PRWEB) September 15, 2014 ... be held on Tuesday, October 21, 2014, from 12:00 ... overview of the program’s innovative curriculum and practice-oriented instruction, ... a graduate degree can help advance their career in ... RSVP online . , About UMBC’s Biotechnology ...
Breaking Biology Technology:iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 3Applied Silicone Launches Silicone Gel System with Dual Matrix Technology 2La International Plasma Awareness Week será una celebración para los donantes 2La International Plasma Awareness Week será una celebración para los donantes 3UMBC Biotechnology Graduate Programs’ Virtual Info Session, October 21, 2014 2
... of intraoperative neurophysiological monitoring in Northern California, publishes the ... The ORIMtec Neurotechnologist Reference Guide is a comprehensive resource ... monitoring tasks. , ... ...
... 11 Signalife,Inc. (Amex: SGN ) announced ... its previously-announced merger or similar business combination with,Heart ... has been,appointed to proceed with due diligence and ... presently contemplated, a new parent,company will be established ...
... 11 Sigma-Aldrich Corporation,(Nasdaq: SIAL ), will ... results on Wednesday, July 23, 2008, at 11:00 ... call is being webcast by Thomson/CCBN and can ... ., The webcast is also being ...
Cached Biology Technology:ORIMtec Releases Industry's First Intraoperative Monitoring Reference Guide for Neurotechnologists 2Signalife Board Approves Merger 2Signalife Board Approves Merger 3Sigma-Aldrich Corporation's 2nd Quarter 2008 Earnings Conference Call 2
... microarrays are derived from Paraffin embedded tissue ... control procedures to ensure the highest quality. ... in one block, sectioned at a thickness ... slides. Sections are large (3-5 mm in ...
ID clarifier: platform...
StemSep Anti-Phycoertherin Tetrameric Antibody Complexes, 2 mL for labeling 1x10 9 cells. Cross-linking Reagent for StemSep Separations of Cells Labeled with PE-conjugated Antibody....
... The PROTEAN II xi multi-cell is for 2-D ... efficient cooling capabilities. The PROTEAN II xi multi-cell ... comb, type of glass plates, and cooling system. ... converted to the PROTEAN II XL multi-cell for ...
Biology Products: