Navigation Links
New gene variants present opportunities in nutrigenomics
Date:12/15/2008

BOSTON (December 15, 2008) ─ A new study uncovers 11 gene variants associated with three blood lipids measured to determine cardiovascular disease risk: low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) and triglycerides. The discovery opens up new opportunities for nutrigenomics researchers looking for links between diet and genetics that will optimize health and lower chronic disease risk.

"Practically all genes related to lipid levels in the bloodstream respond to changes in the diet," says Jose M. Ordovas, PhD, one of five senior authors of the study and director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA). "With this new knowledge, we are closer to identifying precise dietary recommendations for people at risk for cardiovascular disease. For instance, carriers of a certain variant gene could reduce their risk of disease with a low-cholesterol diet, carriers of another variant gene may benefit from the Mediterranean diet, while a high-fiber diet may be the healthiest option for carriers of yet another variant gene."

In addition to the 11 new genes, the authors' findings strengthen the association of 19 previously identified genes with LDL and HDL cholesterol and triglycerides. Ordovas collaborated with 60 authors, led by corresponding author Sekar Kathiresan, MD, of Massachusetts General Hospital, for the study published December 7 online in Nature Genetics December 7. The study is a meta-analysis of over 20,000 subjects in genome-wide association studies of humans in the United States and Europe with The Framingham Heart Study accounting for the largest number of samples.

"Having identified a total of 30 gene variants is a landmark in lipid research," says Ordovas, also a professor at the Friedman School of Nutrition and Science Policy at Tufts and Tufts University School of Medicine "It suggests people can
'/>"/>

Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies genetic variants giving rise to differences in metabolism
2. Interaction between gene variants may alter brain function in schizophrenia
3. Genetic variants of USF1 are associated with the increased risk for cardiovascular disease
4. New genetic variants associated with lipid levels, risk for coronary artery disease
5. Scientists associate 6 new genetic variants with heart disease risk factor
6. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
7. New genes present drug targets for managing cholesterol and glucose levels
8. World Energy Outlook to be presented at Rice University Dec. 9
9. Scientists present moving theory behind bacterial decision-making
10. Arbor Vita presents new data on cancer diagnostic at EUrogin
11. Engineer to present leak-proof method for carbon dioxide storage at international conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... of America (ESA) is pleased to announce the selection ... the Society. Honorary Membership acknowledges those who have served ... in the affairs of the Society that has reached ... by the ESA Governing Board and then voted on ... at the Awards Ceremony at Entomology 2014, ESA,s Annual ...
(Date:8/28/2014)... . The zebrafish, ... striking pattern of blue stripes alternating with golden stripes. Three ... yellow cells emerge during growth in the skin of the ... compose the characteristic colour pattern. ,While it was ... form proper stripes, the embryonic origin of the pigment cells ...
(Date:8/28/2014)... ROCHESTER, Minn. A Mayo Clinic researcher and his ... speed up and enhance the process of re-engineering cells ... that uses network biology methods to aid stem cell ... cell engineering are described in two back-to-back papers in ... has a broad range of uses for all types ...
Breaking Biology News(10 mins):Fred Baxendale selected as Honorary Member of the Entomological Society of America 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3New tool aids stem cell engineering for medical research 2
... to publish its official English-language journal, Human Cell ... at Springer in early 2011. The journal was previously ... a forum for international research on all aspects of human ... studies using ES/iPS cells or tissue stem cells derived from ...
... ANN ARBOR, Mich.---Mercury contamination, a worldwide environmental ... in California,s San Francisco Bay. Mercury mining ... 1900s, combined with present day oil refineries, chemical ... enough mercury to threaten wildlife and prompt a ...
... MOUNTAIN VIEW, CA January 25, 2011 23andMe,s ... both phenotypic and genetic data from 500 individuals diagnosed ... way towards its goal of building a sarcoma research ... completed its Independent Sarcoma Scientific Advisory Committee with the ...
Cached Biology News:Human Cell joins Springer's publishing program 2Mercury in Bay Area fish a legacy of California mining 2Mercury in Bay Area fish a legacy of California mining 323andMe sarcoma research community reaches 500 and announces Sarcoma Scientific Advisory Committee 2
(Date:8/28/2014)... MA (PRWEB) August 28, 2014 “This kit ... test to screen from 0 to 150 ppb,” said Mark ... is a significant benefit to plant owners and USDA-GIPSA inspection ... and other commodities. Testing can take place in a matter ... only can the plant test the feed and grain before ...
(Date:8/28/2014)... -- Next month, executives from clinical trial marketing firm BBK Worldwide ... Patient-Centered Clinical Trials 2014 , to be held at ... September 4-5. Patient recruitment experts Bonnie A. Brescia , ... share insights on the benefits of employing an effective patient ... media to mobile apps – can be used to drive ...
(Date:8/28/2014)... USA (PRWEB) August 27, 2014 Scientists, ... month for SPIE Laser Damage 2014 symposium. ... materials for high-power lasers will run 14-17 September. The ... for optics and photonics . , The premier conference ... understanding laser damage to optical materials will engage researchers ...
(Date:8/28/2014)... New York, NY (PRWEB) August 28, 2014 ... has renewed its long term partnership with PTI ... to provide clients with state of the art leak ... state of the art instruments currently available. As part ... a new High Voltage Leak Detection Instrument ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3
... (Nasdaq: NEOG ) has developed the quickest ... in food and environmental samples. Neogen,s revolutionary ... test available for the system, and will provide results ... available molecular amplification tests require up to 3 hours ...
... RICHMOND, Calif., April 25, 2012  Sangamo BioSciences, Inc. (Nasdaq: ... its first quarter 2012 financial results on Wednesday, May 2, ... followed by a conference call at 5:00 p.m. ET, which ... During the conference call, the company will review the financial ...
...  The Chair of RIFM,s Board of Directors, Dr. Sean ... new president of the Research Institute for Fragrance Materials, ... (Logo: http://photos.prnewswire.com/prnh/20101215/DC17717LOGO ) ... in Piscataway, N. J. where he served as V.P., ...
Cached Biology Technology:Neogen launches the fastest molecular pathogen test 2Sangamo BioSciences Announces First Quarter 2012 Conference Call and Webcast 2RIFM Board Names New President 2
... units/µL ,• High specific activity and processivity ... 'A' overhang ,• Processes ... high activity in primer extension and other ... of the enzyme, each lot has been ...
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/L; 1 tube of 1, 000 units enzyme/tube w/Buffer II and MgCl2...
... 5 units/µL ,• High specific activity and ... an 'A' overhang ,• Processes ... high activity in primer extension and other ... of the enzyme, each lot has been ...
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/uL; 25 tubes of 1, 000 units enzyme/tube w/ Buffer I...
Biology Products: