Navigation Links
New gene variants associated with glucose, insulin levels, some with diabetes risk
Date:1/17/2010

A major international study with leadership from Massachusetts General Hospital (MGH) researchers has identified 10 new gene variants associated with blood sugar or insulin levels. Two of these novel variants and three that earlier studies associated with glucose levels were also found to increase the risk of type 2 diabetes. Along with a related study from members of the same research consortium, associating additional genetic variants with the metabolic response to a sugary meal, the report will appear in Nature Genetics and has been released online.

"Only four gene variants had previously been associated with glucose metabolism, and just one of them was known to affect type 2 diabetes. With more genes identified, we can see patterns emerge," says Jose Florez, MD, PhD, of the MGH Diabetes Unit and the Center for Human Genetic Research, co-lead author of the report. "Finding these new pathways can help us better undertand how glucose is regulated, distinguish between normal and pathological glucose variations and develop potential new therapies for type 2 diabetes."

Both studies were conducted by the Meta-Analyses of Glucose and Insulin-related Traits Consortium (MAGIC), a collaboration among researchers from centers in the U.S., Canada, Europe and Australia that analyzed gene samples from 54 previous studies involving more than 122,000 individuals of European descent. The study co-led by MGH scientists along with colleagues from Boston University, University of Cambridge, University of Oxford and the University of Michigan began by analyzing about 2.5 million gene variations (called SNPs) from 21 genome-wide searches for variants associated with glucose and insulin regulation in more than 46,000 nondiabetic participants. The 25 most promising SNPs from the first phase were then tested in more than 76,000 nondiabetic participants in 33 other studies, leading to new associations of nine SNPs with fasting glucose levels and one with fasting insulin and with a measure of insulin resistance.

Analysis of genetic data from additional studies involving both diabetic and nondiabetic participants found that five glucose-level-associated variants two of those newly identified and three discovered in previous studies were also shown to raise type 2 diabetes risk. Most of the diabetes-associated variants appear to act through their impact on insulin secretion by the pancreatic beta cells and not by insulin resistance, which suggests, the authors note, that environmental factors such as diet, lifestyle and obesity may play a larger role in insulin resistance than in insulin secretion.

"The fact that not all genes involved with raising glucose levels increase diabetes risk tells us that it's not the mere fact of raising glucose that's important but rather how glucose is raised. It's one thing to increase glucose slightly within the normal range and quite another to affect a pathway that eventually leads to progressive glucose elevation, beta-cell failure or insulin resistance in other words type 2 diabetes, " says Florez, who is an assistant professor of Medicine at Harvard Medical School. "We've still only identified about 10 percent of the genetic contribution to glucose levels in nondiabetic individuals, so we need to investigate the impact of other, possibly more complex or rare forms of gene variation, along with the role of gene-environment interactions, in causing type 2 diabetes. Performing similar studies in non-European populations will also be essential."


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Related biology news :

1. Identification of genetic variants affecting age at menopause could help improve fertility treatment
2. Common gene variants influence risk factor for sudden cardiac death
3. Common gene variants increase risk of hypertension, may lead to new therapies
4. International study identifies gene variants associated with early heart attack
5. Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimers
6. New gene variants present opportunities in nutrigenomics
7. Study identifies genetic variants giving rise to differences in metabolism
8. Interaction between gene variants may alter brain function in schizophrenia
9. Genetic variants of USF1 are associated with the increased risk for cardiovascular disease
10. New genetic variants associated with lipid levels, risk for coronary artery disease
11. Scientists associate 6 new genetic variants with heart disease risk factor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
(Date:5/9/2016)... 2016 Elevay is currently known ... freedom for high net worth professionals seeking travel for ... connected world, there is still no substitute for a ... sealing your deal with a firm handshake. This is ... advantage of citizenship via investment programs like those offered ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free validated ... will showcase its product’s latest features from June 26 to June 30, 2016 ... on Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
(Date:6/22/2016)... June 22, 2016 Research and Markets has ... report to their offering. ... 2014 from $29.3 billion in 2013. The market is expected to ... from 2015 to 2020, increasing from $50.6 billion in 2015 to ... forecasts during the forecast period (2015 to 2020) are discussed. As ...
Breaking Biology Technology: