Navigation Links
New gene variants associated with glucose, insulin levels, some with diabetes risk
Date:1/17/2010

A major international study with leadership from Massachusetts General Hospital (MGH) researchers has identified 10 new gene variants associated with blood sugar or insulin levels. Two of these novel variants and three that earlier studies associated with glucose levels were also found to increase the risk of type 2 diabetes. Along with a related study from members of the same research consortium, associating additional genetic variants with the metabolic response to a sugary meal, the report will appear in Nature Genetics and has been released online.

"Only four gene variants had previously been associated with glucose metabolism, and just one of them was known to affect type 2 diabetes. With more genes identified, we can see patterns emerge," says Jose Florez, MD, PhD, of the MGH Diabetes Unit and the Center for Human Genetic Research, co-lead author of the report. "Finding these new pathways can help us better undertand how glucose is regulated, distinguish between normal and pathological glucose variations and develop potential new therapies for type 2 diabetes."

Both studies were conducted by the Meta-Analyses of Glucose and Insulin-related Traits Consortium (MAGIC), a collaboration among researchers from centers in the U.S., Canada, Europe and Australia that analyzed gene samples from 54 previous studies involving more than 122,000 individuals of European descent. The study co-led by MGH scientists along with colleagues from Boston University, University of Cambridge, University of Oxford and the University of Michigan began by analyzing about 2.5 million gene variations (called SNPs) from 21 genome-wide searches for variants associated with glucose and insulin regulation in more than 46,000 nondiabetic participants. The 25 most promising SNPs from the first phase were then tested in more than 76,000 nondiabetic participants in 33 other studies, leading to new associations of nine SNPs with fasting glucose levels and o
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Identification of genetic variants affecting age at menopause could help improve fertility treatment
2. Common gene variants influence risk factor for sudden cardiac death
3. Common gene variants increase risk of hypertension, may lead to new therapies
4. International study identifies gene variants associated with early heart attack
5. Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimers
6. New gene variants present opportunities in nutrigenomics
7. Study identifies genetic variants giving rise to differences in metabolism
8. Interaction between gene variants may alter brain function in schizophrenia
9. Genetic variants of USF1 are associated with the increased risk for cardiovascular disease
10. New genetic variants associated with lipid levels, risk for coronary artery disease
11. Scientists associate 6 new genetic variants with heart disease risk factor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Algae might seem easy to ignore, but they are ... animals depend upon. Humans are increasingly dependent on algae, ... atmosphere and sink it to the bottom of the ... and laboratory experiments, researchers have evidence showing that viruses ... the algae,s blooms, even when all else stays essentially ...
(Date:8/21/2014)... researchers from Beth Israel Deaconess Medical Center (BIDMC ) ... Most Influential Scientific Minds 2014," a comprehensive list ... web resource for science metrics and research performance analysis. ... most influential "are performing and publishing work that their ... science," according to a Thomson Reuters statement. Researchers were ...
(Date:8/21/2014)... 2014 , WHERE: , San Diego Convention ... 92101 , WHAT: , Invited and platform ... research in human genetics. Examples of sessions include: ... rare genetic variants in health and disease, the ... sensitivity (Saturday, Oct. 18, 5:30-7:30 pm) , Crowdsourced ...
Breaking Biology News(10 mins):Viruses take down massive algal blooms, with big implications for climate 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3American Society of Human Genetics 2014 Annual Meeting 2
... A new report launched today by the International Osteoporosis ... Pharmaceutical Industry Associations (EFPIA) reveals that the burden of ... concludes that in Europe,s five largest countries and Sweden ... occurred in 2010 the equivalent of 280 fractures ...
... better ways of encapsulating medicine so that it can reach ... for the first time living human cells to ... agents. The report appears in ACS, journal Nano Letters ... that the human body is very efficient at getting rid ...
... CHICAGO (June 15, 2011) A study of Canadian home-care ... ongoing medical care at home. The study, published in the ... the journal of the Society for Healthcare Epidemiology of America, ... in home-care patients to avoid misuse that could decrease the ...
Cached Biology News:Landmark report reveals immense burden of osteoporotic fractures in Europe 2Study hints at antibiotic overuse in home-care patients 2
(Date:8/22/2014)... particles are intensively investigated for application as ... agents and components in photonics and molecular ... fundamental for understanding physical and chemical properties, ... University, USA, have demonstrated that high-resolution electron ... three-dimensional structure in which all gold atoms ...
(Date:8/22/2014)... -- Research and Markets has announced the ... & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market ... The global molecular biology enzymes market ... expected to grow at a CAGR of 13.74% to ... & reagents find applications in a large number of ...
(Date:8/22/2014)... 22, 2014 “Our nation's healthcare ... a national disgrace. Furthermore, every governmental and professional ... current, deplorable state of unorganized dysfunction shares in ... to merely serve as a device to use ... colossal failure(s) that have accumulated through the years ...
(Date:8/21/2014)... international research team including DESY scientists has observed tiny ... team reports in the journal Science that ... inside the nanodroplets. It is the first time that ... larger samples of what is known as superfluid helium, ... our best expectations," says Andrey Vilesov of the University ...
Breaking Biology Technology:A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 35 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Scientists observe quantum vortices in cold helium droplets 2
... , SOUTH SAN FRANCISCO, Calif., July 23 Anesiva, ... its Current Report on Form 8-K filed with the Securities and ... on April 1, 2009, a letter from the NASDAQ Stock Market ... not in compliance with Marketplace Rule 4450(a)(3) (which has since been ...
... , , ANAHEIM, Calif., ... will showcase a wide spectrum of new and updated products that ... the products on display will be a new version of the ... the product,s speed, precision, and clinical flexibility. The new software ...
... , , SUNNYVALE, ... development of endovascular devices for the treatment of chronic total occlusions ... of Chief Operating Officer. Chris previously held the position of Executive ... of experience in Medical Devices including the last 2 years at ...
Cached Biology Technology:Anesiva Receives NASDAQ Delisting Staff Determination Letter 2Anesiva Receives NASDAQ Delisting Staff Determination Letter 3Varian Medical Systems to Showcase a Wide Spectrum of New and Updated Products That Improve Radiotherapy Treatment Processes at 2009 AAPM Meeting 2Varian Medical Systems to Showcase a Wide Spectrum of New and Updated Products That Improve Radiotherapy Treatment Processes at 2009 AAPM Meeting 3Varian Medical Systems to Showcase a Wide Spectrum of New and Updated Products That Improve Radiotherapy Treatment Processes at 2009 AAPM Meeting 4FlowCardia, Inc. Appoints Chris Barys to Chief Operating Officer 2
... Immunogen: Synthetic peptide derived from the C-terminal ... growth factor D iris-expressed growth factor spinal ... mouse and rat by one amino acid ... kDa human mouse and rat PDGF-D proteins. ...
Antibodies were affinity purified using epitopes specific to USP33 immobilized on solid support....
...
... Fd. ELISA Specificity: (4) ,human IgG subclass 1 ... subclass 3 100% ,human IgG subclass 4 ... 100% ... 0.04% ,human IgG Fab ...
Biology Products: