Navigation Links
New gene-silencing pathway found in plants
Date:11/17/2008

tly.

The Space between Genes

Using Arabidopsis thaliana, the "laboratory rat" of the plant world, Pikaard and his colleagues carried out a series of genetic tests to pinpoint where in the genome Pol V was getting down to business.

Following a hunch, postdoctoral scholar Andrzej Wierzbicki decided to take a closer look at the stretches of DNA that lie between genes, the so-called intergenic regions. Biologists have long been baffled by this alleged "junk DNA" because transcription seems to occur here, and just about everywhere, genes and junk alike.

"This is a hot topic in genetics right now," says Pikaard. "It looks like not just the genes are getting transcribed, but pretty much all of the DNA is getting transcribed. And why? What's the purpose of all this transcription?"

Wierzbicki's instincts paid off. Using high levels of PCR amplification, he determined that Pol V was indeed hard at work within the intergenic region. In this space between genes, Pol V makes noncoding RNA transcripts that he and Pikaard think bind with the siRNAs generated by Pol IV. By acting as a scaffold for these siRNAs, the Pol V transcripts enable silencing of adjacent, virus-derived genes such as retrotransposons (jumping genes) that can be detrimental if activated. Pikaard and colleagues were able to confirm that both Pol IV and Pol V are necessary for silencing by examining mutations that knock out, or disable, the different genes coding for the polymerases.

'Junk' no more

This research adds to a growing body of evidence suggesting that "junk DNA" is in fact a functional part of the genome, since transcription of the intergenic regions is necessary to keep potentially harmful genes turned off. In addition, Pikaard and his colleagues have resolved a paradox that has recently puzzled geneticists: the need for transcription in order to transcriptionally silence the same region. In the case of
'/>"/>

Contact: Craig Pikaard
pikaard@wustl.edu
314-935-7569
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Class of antibiotics can enhance gene-silencing tool
2. Research uncovers new steps on pathway to enlarged heart
3. Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability
4. Breast cancer treatment resistance linked to signaling pathway
5. Combining advanced medical and information technologies offers pathway to lower health care costs
6. USC researchers identify alternate pathway that leads to palate development
7. Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway
8. A new cellular pathway linked to cancer is identified by NYU researchers
9. Gladstone scientists create Wikipathways to foster research collaboration
10. MIT probe may help untangle cells signaling pathways
11. Study identifies brain pathway that shuts down seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... Pa. , June 30, 2015 ... the company as CEO to help further develop Genisphere,s ... wealth of partnering experience, having spent much of the ... including Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. ... focus on Technology and Biotech Corporate Finance. He graduated ...
(Date:6/25/2015)... , June 25, 2015 ... Sensors Market by Type (Swipe & Area), Technology, Material ... Government, Healthcare, Commercial Security & Others) & Geography ... by marketsandmarkets, the said market is expected to ... of 17.1%. Browse 76 market ...
(Date:6/24/2015)... The biologics safety testing market is growing ... market include growth of the pharmaceutical and biological industries ... the years, the number of drug approvals in North ... FDA approved 225 drug applications and Health Canada approved ... accounted for 3,822 of the pharmaceutical and ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... CHICAGO New research using animal models is enabling ... addiction in humans knowledge that may lead to ... that cause people to relapse. The findings were released ... meeting and the world,s largest source of emerging news ...
... Atlanta, GA Current research suggests that latent ... The related report by Onyeagocha et al, "Latent cytomegalovirus ... issue of The American Journal of Pathology . ... in the United States. Most people who are ...
... CLEMSON Algae, not asteroids, were the key ... University researchers. Geologist James W. Castle and ecotoxicologist John ... were a deadly factor in mass extinctions millions of ... into the past but also offers a caution about ...
Cached Biology News:Studies improve knowledge of underlying brain changes caused by addiction 2The bowels of infection 2Clemson researchers say algae key to mass extinctionss 2
(Date:7/27/2015)... -- Junto Health, a company that helps major health ... technology solutions, today announced the launch of a partnership ... health care policy consulting. Working together with SPG, Junto ... process while, at the same time, they are also ... care finance and the delivery of health care services.   ...
(Date:7/25/2015)... ... July 25, 2015 , ... Technology ... It precisely checks and adjusts the surface temperature of the measuring prism. This ... pharmaceutical industry, data traceability and documentation are key requirements. It is likely that ...
(Date:7/24/2015)... , July 24, 2015  Champions Oncology (OTC-BB: ... technology solutions and services to personalize the development and ... its financial and operational results for the fourth quarter ... Tuesday, July 28, 2015, before market open. ... the results that day at 9:00 a.m. EDT (6:00 ...
(Date:7/24/2015)... 2015 , Adds integrated small ... product offering for chronic kidney disease and oncology patients ... complications and dermatology , Increases group revenue and ... ,the Company"), a leading China -based ... biopharmaceutical products, today announced that it has acquired the ...
Breaking Biology Technology:Junto Health Announces a Unique Partnership with Sachs Policy Group 2Junto Health Announces a Unique Partnership with Sachs Policy Group 3Junto Health Announces a Unique Partnership with Sachs Policy Group 4It’s T-Time for Refractometers: On-site Temperature Check Now Available 2Champions Oncology to Announce Fourth Quarter Financial Results on Tuesday, July 28 23SBio Acquires Zhejiang Wansheng Pharmaceutical 23SBio Acquires Zhejiang Wansheng Pharmaceutical 33SBio Acquires Zhejiang Wansheng Pharmaceutical 4
... an information technology and Web products and services provider ... announced today that St. Luke,s Hospital & Health Network ... remote 24/7/365 IT infrastructure monitoring from CareTech,s Healthcare Infrastructure ... and monitoring of data, systems and applications located in ...
... innovative medical imaging informatics company, today announced the commercial ... Edition. Following the April release of their first commercial ... commercial version of their widely accepted DICOM ImageServer software, ... With the release of the PACS, Team Edition, ...
... windows which, thanks to a nanocoating, adjust their level ... to save energy; novel diagnostic methods and tailor-made nano-medicines ... one hand, can be used to make very efficient ... pheromones, protect vineyards from insect attack; new nanostructured materials ...
Cached Biology Technology:St. Luke's Hospital & Health Network Selects CareTech Solutions to Provide Proactive Monitoring of Hospital IT Infrastructure 2St. Luke's Hospital & Health Network Selects CareTech Solutions to Provide Proactive Monitoring of Hospital IT Infrastructure 3ClearCanvas Releases First Commercial Version of Widely Used PACS; Integrated RIS/PACS to Follow 2A world without nano? Soon hard to imagine 2A world without nano? Soon hard to imagine 3
... cell-based assays utilize the membrane-permeant ester ... negatively charged fluorescent beta-lactamase substrates, CCF2 ... enter the cell, where cleavage by ... into their negatively charged forms, thereby ...
...
Homogenizing Solution, 18ml Proteinase K - [50ug/l] 75 l...
...
Biology Products: