Navigation Links
New gene-silencing pathway found in plants
Date:11/17/2008

uld purposefully silence something that you wanted inactivated, that could be a good thing."

Pikaard studies what's known as transcriptional gene silencing. This phenomenon is often regulated by short interfering RNAs, or siRNAs, which University of Cambridge scientist David Baulcombe has called "the dark matter of genetics". By bringing about changes in DNA that interfere with transcription -- the copying of DNA to RNA -- siRNAs can effectively extinguish gene expression at its earliest stage. Pikaard explains, "From yeast to plants to humans these small RNAs can specify the modification of DNA somehow in a way that prevents transcription in the first place." According to Pikaard, most eukaryotes use the same two-pronged method for silencing genes at the transcriptional level: DNA methylation, or adding chemical flags to genes, and modification of proteins called histones that act as spools for DNA.

All eukaryotes share three essential RNA polymerases: Pol I, II, and III. These polymerases are indispensable for expressing biological traits and play a critical role in maintaining basic metabolic functions necessary for survival. "If you're mutated for any of those, you die," says Pikaard. "However, Pol IV and Pol V -- which only plants have -- you don't need them to stay alive but they turn out to be really important for this whole RNA-directed silencing phenomenon."

Since discovering these plant-specific RNA polymerases a few years ago, Pikaard's lab has been on a hunt to figure out what Pol IV and Pol V are making. In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. However, when subsequent genetic tests suggested that Pol V is also needed for gene silencing, but not siRNA production, Pikaard and his colleagues suspected that Pol V and Pol IV cooperate, but work independen
'/>"/>

Contact: Craig Pikaard
pikaard@wustl.edu
314-935-7569
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Class of antibiotics can enhance gene-silencing tool
2. Research uncovers new steps on pathway to enlarged heart
3. Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability
4. Breast cancer treatment resistance linked to signaling pathway
5. Combining advanced medical and information technologies offers pathway to lower health care costs
6. USC researchers identify alternate pathway that leads to palate development
7. Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway
8. A new cellular pathway linked to cancer is identified by NYU researchers
9. Gladstone scientists create Wikipathways to foster research collaboration
10. MIT probe may help untangle cells signaling pathways
11. Study identifies brain pathway that shuts down seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... ability to reliably and safely make in the laboratory all ... one key step closer to reality. , Writing today in ... University of Wisconsin-Madison stem cell researcher Igor Slukvin reports the ... cells and turning them into both red and the array ... research is important because it identifies how nature itself makes ...
(Date:7/13/2014)... of more effective treatments for cachexia, a profound wasting ... all cancer patients, raising their risk of death, according ... have been tried to reverse the condition, which may ... treatments, but none have had great success. , Scientists ... Nature , led by Bruce Spiegelman, PhD, demonstrated ...
(Date:7/11/2014)... many fires burning in eastern New South Wales, Australia ... , At 03:35 UTC on July 11 (12:35 p.m. ... passed over eastern New South Wales (NSW), the Moderate ... image of the region and spotted smoke (light brown) ... thermal bands, are outlined in red. , The New ...
Breaking Biology News(10 mins):Wisconsin scientists find genetic recipe to turn stem cells to blood 2Wisconsin scientists find genetic recipe to turn stem cells to blood 3Antibody halts cancer-related wasting condition 2Antibody halts cancer-related wasting condition 3
... do this has been an abiding mystery in neuroscience and ... area, researchers are taking a closer look at how and ... looks at a particularly striking instance of failure: our impaired ... appears in the Proceedings of the National Academy of ...
... Reid recorded seeing both a male and female ivory-billed ... McKinley Bryans observed a ruby-throated hummingbird in Michigan, noting ... were blooming. These are just two of more than ... in government files. The cards record more than a ...
... release is available in German . , ... this year,s Heinz Maier-Leibnitz Prize, Germany,s top research award for ... of the prize, which has been awarded annually by the ... Ministry of Education and Research since 1977, that the majority ...
Cached Biology News:MIT: Why we have difficulty recognizing faces in photo negatives 2It's for the birds 2It's for the birds 3Heinz Maier-Leibnitz Prizes 2009: Six young researchers recognized for outstanding achievements 2Heinz Maier-Leibnitz Prizes 2009: Six young researchers recognized for outstanding achievements 3Heinz Maier-Leibnitz Prizes 2009: Six young researchers recognized for outstanding achievements 4Heinz Maier-Leibnitz Prizes 2009: Six young researchers recognized for outstanding achievements 5
(Date:7/10/2014)... July 10, 2014 Women in ... access to an additional family planning option. Sayana® ... contraception at all levels of the health system ... of a widely used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone ... Faso is the first of four African countries ...
(Date:7/10/2014)... July 10, 2014 Understanding the need ... cell lines, and the gap that currently exists in ... expand its industry-leading portfolio of validated ion channel and ... channel-expressing cell lines, as ion channels control many critical ... this activity creates the potential to treat a variety ...
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., the ... relaunch of his highly informative blog, now named Stem Cells ... are Stem Cells ?” Dr. Harman’s purpose for blogging ... basics of stem cell therapy so that pet owners can ... when considering regenerative medicine. , A veterinarian by trade, Dr. ...
(Date:7/10/2014)... July 10, 2014 Senior supply chain ... professional associations, addressed the challenges of “Reducing Cost, Lead ... Industries” through strategic sourcing. Describing the partnership of the ... Supply Chain Management Institute ( SCMI) of the ... June 24 at the Kroc Institute of Peace and ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4
... Pity the female fruit fly. Being a looker is simply not ... to act like a girl, even smell like one. Otherwise, you ... most animals, fruit flies must distinguish between a potential mate and ... a female, he,ll court; when he senses the other is a ...
... developed a new measurement-based approach to environmental noise monitoring ... Castle Group, QinetiQ and Hoare Lea Acoustics, and with ... (a Distributed Remote Environmental Array & Monitoring System). ... MEMS (Micro Electro Mechanical Systems) microphones to provide a ...
... the search for the next generation of semiconductors. ... Berkeley National Laboratory (Berkeley Lab) and the University ... layers of the semiconductor indium arsenide onto a ... excellent electronic properties. A member of the IIIV ...
Cached Biology Technology:Battle of the sexes, fruit-fly style 2Novel use of MEMS microphones to map noise pollution and meet EU directives 2Novel use of MEMS microphones to map noise pollution and meet EU directives 3Ultrathin alternative to silicon for future electronics 2Ultrathin alternative to silicon for future electronics 3
Oven mesh sheets, large, 23 x 23cm, pack of 5...
... Phosphatase ( l-PPase) is ... with activity towards phosphorylated ... residues. It is the ... the ORF221 open reading ...
... is a high performance spectral scanning ... incubator. With the advanced SkanIt Software ... for drug discovery assay development. Varioskan ... intensity, time-resolved fluorescence and photometric assays ...
... refrigerated cold traps offers a choice of ... solvents or high volatility solvents. Ideal to ... evaporators. Also used for maintaining vapor-free gas ... in electron microscopes. Can be used as ...
Biology Products: