Navigation Links
New gene associated with increased risk of Alzheimer's disease
Date:4/14/2010

TORONTO Researchers have identified a gene that appears to increase a person's risk of developing late-onset Alzheimer's disease, the most common type of Alzheimer's disease. The research will be presented as part of the late-breaking science program at the American Academy of Neurology's 62nd Annual Meeting in Toronto, April 10 17, 2010. The gene, abbreviated MTHFD1L, is located on chromosome six.

"Only recently have common variants in genes other than APOE been convincingly shown to be associated with a person's risk of developing late-onset Alzheimer's disease," said senior author Margaret Pericak-Vance, PhD, the principal investigator of the study and Director of the University of Miami Miller School of Medicine's John P. Hussman Institute for Human Genomics in Miami, Florida.

Researchers looked at gene variation throughout the human genomes of 2,269 people with late-onset Alzheimer's disease and 3,107 people without the disease through what's known as a genome-wide association study. Such studies involve looking at long stretches of DNA to identify small differences in the genetic sequence between people with and without Alzheimer's disease.

The study found that individuals with a particular variation in the gene MTHFD1L may be almost twice as likely to develop Alzheimer's disease as those people without the variation. "We are hopeful our identification of MTHFD1L as a risk gene for Alzheimer's disease will help us to better understand how this disease develops and potentially serve as a marker for people who may be at increased risk," said Adam Naj, PhD, with the University of Miami Miller School of Meidicne's John P. Hussman Institute for Human Genomics in Miami and the first author of the abstract reporting the discovery.

"Identifying this gene is important because the gene is known to be involved in influencing the body's levels of homocysteine, and high levels of homocysteine are strong risk factor for late-onset Alzheimer's disease," said Pericak-Vance. "In addition, variations of the MTHFD1L gene have been reported to possibly increase the risk of coronary artery disease. Since the function of blood vessels in the brain may affect Alzheimer's disease, this finding may also help us understand how homocysteine levels and blood vessel function in the brain affect Alzheimer's disease."

The World Health Organization estimates that there are currently 18 million people worldwide with Alzheimer's disease, and this figure is projected to nearly double to 34 million by 2025. There are currently at least five million Americans living with Alzheimer's disease today.


'/>"/>

Contact: Rachel Seroka
rseroka@aan.com
651-695-2738
American Academy of Neurology
Source:Eurekalert

Related biology news :

1. Depression associated with sustained brain signals
2. Scientists identify age-associated defects in schizophrenia
3. Study finds variations in 1 gene may be associated with endurance running
4. Epigenetics could help researchers determine any risks associated with low-dose radiation
5. New gene variants associated with glucose, insulin levels, some with diabetes risk
6. Consumption of certain fish during pregnancy associated with poorer cognitive performance
7. Attention-deficit/hyperactivity problems associated with low folate levels in pregnant women
8. New chromosomal abnormality identified in leukemia associated with Down syndrome
9. Mediterranean diet associated with reduced risk of depression
10. Study finds 231 new genes associated with head and neck cancer
11. Barrow scientist awarded $400,000 grant to study cell associated with intuition and autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... ... and Markets has announced the addition of the "Global Military Biometrics ... forecasts the global military biometrics market to grow at a CAGR of ... prepared based on an in-depth market analysis with inputs from industry experts. ... coming years. The report also includes a discussion of the key vendors ...
(Date:12/15/2016)... 15, 2016  There is much more to innovative ... the engine. Continental will demonstrate the intelligence of today,s ... . Through the combination of the keyless entry ... biometric elements, the international technology company is opening up ... authentication. "The integration of biometric elements brings ...
(Date:12/12/2016)...  Researchers at Trinity College, Dublin, are opening ... the material with Silly Putty. The mixture (known as ... to sense pulse, blood pressure, respiration, and even ... The research team,s findings were published Thursday ... http://science.sciencemag.org/content/354/6317/1257 ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... ... January 20, 2017 , ... The two newest companies to join ... patients. Vironika, a spin out from The Wistar Institute, and Sanguis, launched by a ... 3624 Market Street. , Vironika is developing a treatment for a chronic viral ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... the next evolution in spinal fusion, the MISquito Percutaneous Pedicle Screw System ... competition, SpineFrontier is focused on technique driven product solutions that provide maximum ...
(Date:1/19/2017)... , Jan. 19, 2017 /PRNewswire -- WuXi AppTec, ... open-access capability and technology platform, today announced that ... biology focused preclinical drug discovery contract research organization ... become a wholly-owned subsidiary of WuXi, and will ... and providing greater services. The acquisition will further ...
(Date:1/19/2017)... GAITHERSBURG, Md. , Jan. 19, 2017 ... Inc., a privately-held immunotherapeutics company targeting infectious diseases, ... for the merger of PharmAthene and Altimmune in ... Venture Fund, HealthCap, Truffle Capital and Redmont Capital. ... diversified immunotherapeutics company with four clinical stage and ...
Breaking Biology Technology: