Navigation Links
New gel to promote bone growth on implants used in surgical procedures
Date:3/30/2014

A research group at Uppsala University, Sweden has developed a new responsive coating for implants used in surgery to improve their integration into bone and to prevent rejection. Neutron scattering experiments at the Institut Laue-Langevin (ILL) in Grenoble, France have shown how a protein that promotes bone growth binds to this surface and can be released in a controlled way.

Orthopaedic and dental implants must last for many years. Success for these surgical components depends on integration into adjacent bone tissue. Gels made by modifying hyaluronan, a large biological molecule, can be used to coat implants. A new paper in Advanced Engineering Materials shows that the coated titanium surfaces can bind protein molecules which promote bone formation. These can be released slowly once the surface comes in contact with a solution of calcium ions. This process would stimulate the growth of bone on the implant.

The gel layers, a few millionths of a millimetre thick, were characterised using neutron reflection at the ILL, a technique that provides a detailed picture of what happens at a surface. In their new paper the research team showed that the protein, BMP-2, that encourages bone growth was bound to the gel. They also demonstrated that the layer of protein was stable in water but could be released slowly by adding solutions containing calcium, a process that was observed in real time using neutron reflection to track the amount of protein at the surface.

The research group has now launched trials of similar materials for metal implants in rabbits. These ongoing studies are made in collaboration with the Swedish Agricultural University in Uppsala and they provide a step towards transfer of the results to clinical applications.

'Interdisciplinary research and partnerships allow advanced analytical tools to be applied to important but difficult medical and scientific challenges. This exciting work comes from shared goals of chemists and physicists as well as the Centre for Neutron Scattering at Uppsala University and the laboratories in Grenoble', says Professor Adrian Rennie.

'We envisage that the materials will be used in medicine to modulate the healing process in bone', says Associate Professor Dmitri Ossipov. He continues, 'Neutrons are an ideal tool to understand the interactions of metal surfaces, polysaccharide biopolymers, and proteins thanks to a contrast matching technique that highlights only the protein components at the interface.'

'Neutron scattering techniques are increasingly relevant to optimise bio-materials and to study systems that relate to health. The importance of combining conventional laboratory studies with those at a large scale facility to give a complete picture of a process was proven once more. This work arose from a studentship funded by the Institut Laue-Langevin which makes us proud of our PhD programme.' says Dr Giovanna Fragneto from the Institut Laue-Langevin.


'/>"/>

Contact: Adrian Rennie
Adrian.Rennie@physics.uu.se
46-070-425-0914
Uppsala University
Source:Eurekalert  

Related biology news :

1. Tracking neighborhood eating habits to promote healthier diets
2. An innovative approach to promote water use efficiency
3. First-ever book on Mekong rattan species aims to promote sustainable practices
4. Manga comics may help promote fruit consumption among youth
5. Large amounts of folic acid shown to promote growth of breast cancer in rats
6. Neurotransmitters resarch can promote better drugs for brain disorders
7. Mannotriose promotes survival of hippocampal neurons
8. Gene promotes 1 in 100 of tumors
9. New research shows tea may help promote weight loss, improve heart health and slow progression of prostate cancer
10. Treadmill step training promotes motor function after incomplete spinal cord injury
11. Dysfunctional chemokine receptor promotes candidiasis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New gel to promote bone growth on implants used in surgical procedures
(Date:1/24/2017)... , Jan. 24, 2017 Biopharm ... of the laboratory use of nuclear magnetic resonance ... experienced end-users and profiled current practices, developments, trends ... as well as growth and opportunities. These areas ... suppliers, NMR instruments, needs and innovation requirements, hyphenated ...
(Date:1/21/2017)... Research and Markets has announced the addition ... to their offering. ... The global voice recognition biometrics market to grow at a ... report covers the present scenario and the growth prospects of the ... size, the report considers the revenue generated from the sales of ...
(Date:1/18/2017)...  In vitro diagnostic (IVD) companies were very active ... and Kalorama Information expects that trend to continue – ... Generally, uncertainty in reimbursement and healthcare reform in ... the acquisitions landscape. Instead of looking to buy technology, ... outside of their home country and also to increase ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... ... February 22, 2017 , ... LabRoots , the leading provider ... the world, is pleased to announce the launch of a new scholarship for young ... fields. , This merit-based scholarship is open to all high school seniors, 17 years ...
(Date:2/22/2017)... 22, 2017 Aethlon Medical, Inc. (Nasdaq: ... study that validated the ability of the Aethlon Hemopurifier® ... increased mortality in immune-suppressed sepsis patients and also contribute ... The objective of the study was to validate the ... virus (EBV) and Herpes Simplex virus 1 (HSV1) by ...
(Date:2/22/2017)... and SAN DIEGO , Feb. ... "Company") (OTCQB:CELZ) announced today expansion of its translational ... cell product through establishment of laboratory facilities in ... at the San Diego BioLabs facility, a biotechnology ... Novartis, and Sanofi. In November 2016, ...
(Date:2/21/2017)... , Feb. 21, 2017 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" ... and operational results for the three months ended December 31, ... -based life sciences and diagnostics company that develops and ... ... continue to build on the commercial milestones achieved in fiscal ...
Breaking Biology Technology: