Navigation Links
New function for a well-known immune messenger molecule
Date:8/26/2013

their own function directly," says Halin. So far, IL-7 is one out of only few molecules that have been identified to support lymphatic drainage. A few years ago, other researchers discovered that the endogenous growth factor VEGF-C might also be an interesting molecule in this regard.

Insights from an animal model

Halin and her colleagues demonstrated the drainage-supporting function of IL-7 by performing drainage experiments in mice where they injected a blue, albumin-binding dye into the ear skin of the mice. Notably, albumin is an endogenous protein, which can only be transported out of the tissue via the lymphatic vessels. By quantifying the dye that remained in the tissue one day after the injection, the researchers were able to determine how well the lymphatic drainage worked in these laboratory animals.

When performing this experiment in mice lacking a functioning IL-7 receptor, they observed that these mice were only able to remove half as much dye from their ear skin in comparison with mice possessing a functional IL-7 receptor. By contrast, they observed a considerable increase in lymphatic drainage in mice with increased IL-7 production. Finally, in a third experiment, they administered IL-7 protein to unmodified, healthy mice and observed that this therapeutic treatment led to an improvement of lymphatic drainage function.

Already tested in patients

The scientists are now planning to conduct similar experiments in mice in which lymphatic vessels have been surgically destroyed, similarly to the situation found in patients after cancer surgery. Here, the researchers would like to test whether treatment with IL-7 could help to prevent lymphedema or whether IL-7 could even be administered in order to reduce existing lymphedema.

The long-term goal is to explore the potential of an IL-7-based medication for lymphedema. Notably, IL-7 is already being tested in clinical trials, albeit for d
'/>"/>

Contact: Cornelia Halin
cornelia.halin@pharma.ethz.ch
41-446-332-962
ETH Zurich
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Fetal stem cell transplantation favorably impacts radiation-induced cognitive dysfunction
2. Hitting the gym may help men avoid diet-induced erectile dysfunction
3. Study reveals potential role of love hormone oxytocin in brain function
4. Advance in regenerative medicine could make reprogrammed cells safer while improving their function
5. U of M researchers identify new functions for autoimmune disease risk gene
6. People with impaired glucose tolerance can show cognitive dysfunction
7. Protein targeted for cancer drug development is essential for normal heart function
8. Early life and in utero factors found to influence testicular function in adulthood
9. Bladder function restored in animals with severe spinal cord injury
10. UMass Amherst researchers develop powerful new technique to study protein function
11. A peptide to protect brain function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... could be as simple as inserting a medicated, disappearing ... Washington bioengineers have discovered a potentially faster way to ... HIV. Their method spins the drug into silk-like fibers ... higher doses of the drug than possible with other ... could offer women a potentially more effective, discreet way ...
(Date:7/30/2014)... figured out how to create colors, nature had already ... of many different hues, for example. Now scientists are ... friendly way to make colored plastics. Their paper on ... materials rather than dyes, to produce color appears ... N. Asger Mortensen, Anders Kristensen and colleagues point out ...
(Date:7/30/2014)... awarded the Scientific Committee on Antarctic Research,s (SCAR) ... SCAR, an inter-disciplinary international science body, initiates, develops ... the Antarctic region, and on the role of ... organisation also provides scientific advice about Antarctica to ... region. , The medal is open internationally to ...
Breaking Biology News(10 mins):Dissolvable fabric loaded with medicine might offer faster protection against HIV 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 3
... CORVALLIS, Ore. An international group of more than 30 ... their contribution to the health of the world,s oceans, which ... identified food provision, tourism and recreation as leading concerns. ... each nation on a 0-100 scale in 10 separate categories ...
... on fetal growth have consistently demonstrated deficits that persist ... human studies have been inconsistent. A new study ... on growth and body composition throughout childhood has found ... age, as well as a delay in weight gain ...
... cells has provided scientists at Dana-Farber Cancer Institute and the ... entirely new class of genes that may serve as an ... in the Aug. 17 issue of the journal Cell ... of which had previously been identified as potential targets for ...
Cached Biology News:Rating of ocean health shows 'room for improvement' 2Tracking the effects of prenatal alcohol exposure through to 9 years of age 2Tracking the effects of prenatal alcohol exposure through to 9 years of age 3'CYCLOPS' genes may serve as an Achilles' heel in tumor cells 2'CYCLOPS' genes may serve as an Achilles' heel in tumor cells 3
(Date:7/30/2014)... Mass. , July 30, 2014 /PRNewswire/ ... ), a biotechnology company focused on discovering, ... unmet medical needs using RNA-targeted technologies, today ... (RXI-109-1402) with RXI-109, for the reduction of ... revision surgery, has been initiated. ...
(Date:7/30/2014)... Diego, CA (PRWEB) July 30, 2014 ... contract from the U.S. Environmental Protection Agency (EPA). ... expertise in developmental toxicity models, including tests designed ... neuron formation and the formation of connections between ... Inhibition of neurodifferentiation and synapse formation by environmental ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 LayerBio, Inc., ... completion of its first round of seed financing from ... enable preliminary efforts to develop a novel sustained-release product ... of our investors and their commitment to this important ... LayerBio. "Ophthalmology is one of many areas in which ...
(Date:7/29/2014)... hurdled a number of significant technological challenges in ... technology originally created for the James Webb Space ... Harvey Moseley, a scientist at NASA,s Goddard Space ... electrostatically actuated microshutter arrays that is, those ... as functional as the current technology,s magnetically activated ...
Breaking Biology Technology:RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 2RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 5U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4
... 30 Rib-X Pharmaceuticals, Inc., a development stage company focused ... treatment of antibiotic resistant infections, announced today that Russell Greig, ... the Company,s Board of Directors. Rib-X,s board now consists ... pleased that Russell Greig has joined the Rib-X Board of ...
... ... Northern Irish packaging machinery manufacturer, Sepha Ltd. is breaking into one of ... testing and de-blistering machines for the first time there ... Ahead of its presence at Interphex, Sepha has already received ...
... /PRNewswire-Asia/ -- Pharmaxis (ASX: PXS; Nasdaq: PXSL ),today ... Plan which,closed on 24 June 2009. Shareholders of the ... of shares each at the $2.35 price,paid by institutional investors ... total of 1,584 shareholders participated in the plan under which ...
Cached Biology Technology:Rib-X Pharmaceuticals, Inc. Appoints Dr. Russell Greig to Board of Directors 2Rib-X Pharmaceuticals, Inc. Appoints Dr. Russell Greig to Board of Directors 3Asia Debut for Money-Saving Pharma-Packaging Machines from Ireland 2Asia Debut for Money-Saving Pharma-Packaging Machines from Ireland 3Pharmaxis Closes Share Purchase Plan 2
... is most widely used in combination ... differentially stain nucleic acids following polyacrylamide ... solution, Pyronin Y stains RNA red, ... Chem comp: Dye content ...
... The loxP-cm-loxP cassette is ... prokaryotic cells. The prokaryotic promoter ... resistance is a slightly modified version ... higher transcription efficiency than the generally ...
... Agencourt AMPure is a ... that requires no sample transfer, ... efficiently purifies small and large ... or 384-well microplates. Agencourt AMPure ...
... is a magnetic bead-based PCR ... sample transfer, centrifugation or filtration ... and large PCR extension products ... Agencourt AMPure can easily be ...
Biology Products: