Navigation Links
New fluorescent tools for cancer diagnosis

In recent years, microRNAs (miRNAs) and other non-coding RNAs are small molecules that help control the expression of specific proteins. In recent years they have emerged as disease biomarkers. miRNA profiles have been used to establish tissue origin for cancers of unknown primary origin, determine prognosis, monitor therapeutic responses and screen for disease, but clinically tractable, diagnostic methods for monitoring miRNA expression in patient samples are not currently available. In this issue of the Journal of Clinical Investigation, Thomas Tuschl and colleagues at Rockefeller University developed a multicolor fluorescence labeling method that can be used to visualize miRNAs in tissue sections, such as those recovered from biopsies. Using this method, Tuschl and colleagues were able to identify tumor specific miRNAs in basal cell carcinoma and Merkel cell carcinoma (accompanying image) and distinguish between FFPE sections from the two tumor types. This proof-of concept study indicates that RNA FISH could serve as a molecular diagnostic in a clinical setting. In a companion commentary, Gennadi Glinksy of Stanford University discusses how this technology could contribute to the development of RNA-based diagnostics and therapeutics.


Contact: Jillian Hurst
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
2. A non-invasive intracellular thermometer with fluorescent proteins has been created
3. Fluorescent light revealed as gauge of coral health
4. Genetic research develops tools for studying diseases, improving regenerative treatment
5. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
6. Researchers announce GenomeSpace environment to connect genomic tools
7. Michael J. Fox Foundation grant to Dr. Samuel Young will provide Parkinsons drug development tools
8. New tools for evaluating quality of life for cats, dogs with heart disease
9. UMass Amherst biochemists developing tools to stop plague and other bacterial threats
10. DataONE answers the call for new tools to study the Earth in this era of Big Data science
11. Forensic tools for catching poachers
Post Your Comments:
(Date:11/18/2015)... November 18, 2015 --> ... a new market report titled  Gesture Recognition Market - ... 2015 - 2021. According to the report, the global gesture recognition ... anticipated to reach US$29.1 bn by 2021, at a ... North America dominated the global gesture ...
(Date:11/17/2015)... LIVERMORE, Calif. , Nov. 17, 2015  Vigilant ... has joined its Board of Directors. ... Vigilant,s Board after recently retiring from the partnership at ... owning 107 companies with over $140 Billion in revenue.  ... performance improvement across all the TPG companies, from 1997 ...
(Date:11/12/2015)... , Nov. 12, 2015  A golden retriever ... Duchenne muscular dystrophy (DMD) has provided a new lead ... Children,s Hospital, the Broad Institute of MIT and Harvard ... Brazil . Cell, pinpoints ... dogs "escape" the disease,s effects. The Boston Children,s lab ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... LAVAL, QC , Nov. 24, 2015 /CNW Telbec/ - ... the "Corporation") announced today that Mr. Pierre Laurin , ... a corporate presentation at the upcoming Piper Jaffray 27 th ... York Palace Hotel, on December 1-2, 2015. ... be available for one-on-one meetings throughout the day. The presentation ...
(Date:11/24/2015)... -- PDL BioPharma, Inc. (PDL) (NASDAQ: PDLI ) today announced ... chief executive officer, will present at the 27 th ... New York City . The presentation will be webcast ... 9:30 a.m. EST. and go to ... 15 minutes prior to the presentation to allow for any ...
(Date:11/24/2015)... According to two new studies, fewer men are ... that many doctors, scientists, and public health experts have been ... PSA tests being done, will there be more men dying ... Samadi, "Despite the efforts made in regards to early ... cancer cause of death in men, killing approximately 27,500 men ...
(Date:11/23/2015)... Cord Blood Corporation (NYSE: CO ) ("CCBC" or ... laboratory testing, hematopoietic stem cell processing, and stem cell ... for the second quarter and first half of fiscal ... --> --> Second Quarter of Fiscal ... of fiscal 2016 increased by 12.7% to RMB171.5 million ...
Breaking Biology Technology: