Navigation Links
New findings in the search for genetic clues to insulin production
Date:12/23/2012

(Embargoed) CHAPEL HILL, N.C. In research published online Dec. 23, 2012 in the journal Nature Genetics, scientists have found three new and relatively rare genetic variants that influence insulin production, offering new clues about the genetic factors behind diabetes..

"Studying genetic variants even rare ones helps us learn how genes affect health and disease," said Karen Mohlke, PhD, one of the study's senior authors and associate professor of genetics at the University of North Carolina School of Medicine. "In this study, we've implicated new genes as playing a role in insulin processing and secretion."

The study is also the first time genetic insights have been reported using exome array genotyping, a new tool that is less costly than genetic sequencing. This analysis allows scientists to quickly screen DNA samples for known variants in specific genes. It is especially helpful for testing variants that are rare.

"The exome array allowed us to test a large number of individuals in this case, more than 8,000 people very efficiently," said Mohlke. "We expect that this type of analysis will be useful for finding low-frequency variants associated with many complex traits, including obesity or cancer."

The scientists pulled data from a large health study directed by researchers at the University of Eastern Finland. A research team including postdoctoral scientist Jeroen Huyghe at the University of Michigan, Ann Arbor led the statistical analysis, which integrated genetic data and detailed health records for a sample of 8,229 Finnish males.

Diabetes, which affects more than 25 million people in the United States, results from problems with the body's ability to produce or use insulin. Rather than pinpointing one gene behind the disease, scientists believe there are a whole host of genes that interact with health and lifestyle factors to influence a person's chances of getting the disease.

The study revealed that certain variants of three genes called TBC1D30, KANK1 and PAM are associated with abnormal insulin production or processing, even in people without diabetes. The genes may predispose such individuals to developing the disease.

As a next step, the researchers plan to continue to investigate how these genes may lead to diabetes. They also expect the results will inspire other scientists to use exome analysis to look at the genetic factors behind other complex diseases.


'/>"/>
Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina Health Care
Source:Eurekalert  

Related biology news :

1. The findings between DNMs and autism provides global view of mutability on human diseases
2. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
3. Verinata Health Announces New Findings At The American Society Of Human Genetics
4. New findings on gene regulation and bone development
5. New findings on protein misfolding
6. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
7. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
8. Researchers discover genetic basis for eczema, new avenue to therapies
9. Native orchid protection and conservation subject of new AgriLife Research study
10. Thomas Jefferson University researchers discover new pathways that drive metastatic prostate cancer
11. Carin Görings remains identified by researchers at Uppsala University
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New findings in the search for genetic clues to insulin production
(Date:2/9/2016)... 9, 2016 Vigilant Solutions announces today that an ... to develop a lead in a difficult homicide case. The ... to locate the suspect vehicle. Due to the ongoing investigation, ... been omitted at the agency,s request. --> ... "Our victim was found deceased at an intersection here in ...
(Date:2/8/2016)... PRAGUE, Czech Republic , February 8, 2016 ... first EU-regulated global payment platform which presents innovation ... Voice Biometrics Authentication feature called VoiceKey. --> ... payment platform which presents innovation for clients, comfort ... feature called VoiceKey. --> Worldcore ...
(Date:2/5/2016)... 5, 2016 http://www.researchandmarkets.com/research/5kvw8m/global_facial ... "Global Facial Recognition Market 2016-2020" ... http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the addition of ... report to their offering. --> ... has announced the addition of the ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... DelveInsight,s, "Protein-Tyrosine Phosphatase ... in depth insights on the pipeline drugs ... Phosphatase 1B (PTP1B) Inhibitors. The DelveInsight,s Report ... of development including Discovery, Pre-clinical, IND, Phase ... Report covers the product clinical trials information ...
(Date:2/8/2016)... 8, 2016  CytRx Corporation (NASDAQ: CYTR ... in oncology, today announced that it has entered ... Hercules Technology Growth Capital, Inc. and Hercules Technology ... financing. --> --> ... of financing under the loan and security agreement.  ...
(Date:2/8/2016)... ... February 08, 2016 , ... Thomas J. Todorow ... Executive Vice President for Corporate Services and the Chief Financial Officer at The ... Billing Operations, Treasury, Managed Care Contracting, Supply Chain, and Investments. , Prior to ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... wide range of loose, bulk foods at various stages of the production process. ... used to inspect large bulk products post packaging such as sacks of dry ...
Breaking Biology Technology: