Navigation Links
New findings in the search for genetic clues to insulin production
Date:12/23/2012

(Embargoed) CHAPEL HILL, N.C. In research published online Dec. 23, 2012 in the journal Nature Genetics, scientists have found three new and relatively rare genetic variants that influence insulin production, offering new clues about the genetic factors behind diabetes..

"Studying genetic variants even rare ones helps us learn how genes affect health and disease," said Karen Mohlke, PhD, one of the study's senior authors and associate professor of genetics at the University of North Carolina School of Medicine. "In this study, we've implicated new genes as playing a role in insulin processing and secretion."

The study is also the first time genetic insights have been reported using exome array genotyping, a new tool that is less costly than genetic sequencing. This analysis allows scientists to quickly screen DNA samples for known variants in specific genes. It is especially helpful for testing variants that are rare.

"The exome array allowed us to test a large number of individuals in this case, more than 8,000 people very efficiently," said Mohlke. "We expect that this type of analysis will be useful for finding low-frequency variants associated with many complex traits, including obesity or cancer."

The scientists pulled data from a large health study directed by researchers at the University of Eastern Finland. A research team including postdoctoral scientist Jeroen Huyghe at the University of Michigan, Ann Arbor led the statistical analysis, which integrated genetic data and detailed health records for a sample of 8,229 Finnish males.

Diabetes, which affects more than 25 million people in the United States, results from problems with the body's ability to produce or use insulin. Rather than pinpointing one gene behind the disease, scientists believe there are a whole host of genes that interact with health and lifestyle factors to influence a person's chances of getting the disease.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina Health Care
Source:Eurekalert  

Page: 1 2

Related biology news :

1. The findings between DNMs and autism provides global view of mutability on human diseases
2. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
3. Verinata Health Announces New Findings At The American Society Of Human Genetics
4. New findings on gene regulation and bone development
5. New findings on protein misfolding
6. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
7. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
8. Researchers discover genetic basis for eczema, new avenue to therapies
9. Native orchid protection and conservation subject of new AgriLife Research study
10. Thomas Jefferson University researchers discover new pathways that drive metastatic prostate cancer
11. Carin Görings remains identified by researchers at Uppsala University
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New findings in the search for genetic clues to insulin production
(Date:7/11/2014)... normal circumstances, astrocytes participate in normal physiological ... exhibit therapeutic and repairing effects on brain ... found that nerve cells differentiated from adipose-derived ... viability, which produces influences on subsequent studies ... Hospital, Hebei United University, China demonstrated that ...
(Date:7/11/2014)... Using spider toxins to study the proteins that let ... say they have stumbled upon a biological tactic that ... insect plagues in a safe and environmentally responsible way. ... be lethal for one species and harmless for a ... target specific pests without harming beneficial species like bees. ...
(Date:7/10/2014)... COLORADO SPRINGS, Colo. , June 27, 2014 ... announces that the National Institute of Standards and ... appointed 10 of its academic research and forensic ... Board (FSSB).  The Board is an element of ... These AAFS members are among the first appointments ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... Winning Imperatives... -- DALLAS, August 18, 2010 ... ... ... are keyed by longUrl, so we need to grab the first one. for (var r in ...
... set of sugars found on some disease-causing pathogens helps ... as vaccines, say two Iowa State University researchers. ... a disease family that includes tuberculosis for which there ... Pohl, professor of chemistry, and Christine Petersen, assistant professor ...
... In much of Africa, a herd of cattle is ... dowry, funeral fund, symbol of wealth, and hedge against drought. ... cow to disease can spell ruin. Yet a grievous ... puts annual losses from disease at $40 billion, some twenty-five ...
Cached Biology News:New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 2New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 3New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 4New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 5New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 6New Report - Bioinformatics Market - Advanced Technologies, Global Forecast and Winning Imperatives (2009 - 2014) By MarketsandMarkets 7ISU researchers discover cause of immune system avoidance of certain pathogens 2ISU researchers discover cause of immune system avoidance of certain pathogens 3Cow vaccines go vroom 2Cow vaccines go vroom 3
(Date:7/11/2014)... , Not for release, publication or distribution (in ... where to do so would constitute a violation of the ... or the "Company") (LSE: SHP, NASDAQ: SHPG ) ... held a meeting with representatives of AbbVie. This ... or approval of AbbVie. A further update will ...
(Date:7/11/2014)... EPFL and the University of  Geneva  (UNIGE) ... P. Donoghue . The American neuroscientist is to head ... The new Wyss Center for Bio- and Neuro-Engineering, ... , has named as its director one of the ... founder of Brown University,s Institute for Brain Science, has ...
(Date:7/11/2014)... Cayenne Medical, Inc., a privately held ... tissue reconstruction segment, announced the worldwide launch of ... the shoulder and extremities. The SureLock System provides ... method. The unique delivery eliminates manual tensioning that ... anchor displacement (also commonly know as anchor “creep”). ...
(Date:7/10/2014)... 2014 Deep Knowledge Ventures last ... on ‘Commercialising Longevity Research’ and welcomed a host ... London Bioscience Innovation Center for the event, organised ... Analytics Ltd. The meeting highlighted the need for ... for age-related disease, as well as the crucial ...
Breaking Biology Technology:Shire plc - Statement re: Media Speculation 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6
... ... Trusted LASIK Surgeons launched its revolutionary Trusted LASIK Surgeons directory service and ... consumers seeking to improve their vision and find a highly qualified eye ... Trusted LASIK Surgeons directory apart is a unique screening process ensuring that ...
... SHANGHAI, Aug. 9 /PRNewswire-Asia/ -- WuXi PharmaTech (Cayman) ... at its annual,general meeting of shareholders held in Hong Kong ... http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ) , At ... B directors Xuesong Leng, Zhaohui Zhang, and Ning Zhao, each,to ...
... in modern manufacturing techniques,has made it possible to ... direct response to the extreme demands of quality,assurance ... microsystem parts, extensive research,is being carried out in ... ,Microparts, is a joint EURAMET research project,in the ...
Cached Biology Technology:Trusted LASIK Surgeons Welcomes Fort Lauderdale Vision Correction Surgery Expert Raymond P. Gailitis, M.D., F.A.C.S. 2Trusted LASIK Surgeons Welcomes Fort Lauderdale Vision Correction Surgery Expert Raymond P. Gailitis, M.D., F.A.C.S. 3Trusted LASIK Surgeons Welcomes Fort Lauderdale Vision Correction Surgery Expert Raymond P. Gailitis, M.D., F.A.C.S. 4Trusted LASIK Surgeons Welcomes Fort Lauderdale Vision Correction Surgery Expert Raymond P. Gailitis, M.D., F.A.C.S. 5Trusted LASIK Surgeons Welcomes Fort Lauderdale Vision Correction Surgery Expert Raymond P. Gailitis, M.D., F.A.C.S. 6Trusted LASIK Surgeons Welcomes Fort Lauderdale Vision Correction Surgery Expert Raymond P. Gailitis, M.D., F.A.C.S. 7Trusted LASIK Surgeons Welcomes Fort Lauderdale Vision Correction Surgery Expert Raymond P. Gailitis, M.D., F.A.C.S. 8WuXi PharmaTech Announces Shareholder Resolutions Adopted at 2009 Annual General Meeting 2
... controlled pre-amplifier suitable for a broad range ... for recording physiological signal such as ECG, ... input for use with a wide range ... include a stimulus artefact clamp to avoid ...
... be used with all 96-well ... stacking of covered plates ... with automated systems ... are available for use with ...
... Two sizes available for use with 96- or 384-well ... 96 for ease of location on 96-tube plates ... the skirt of the plate* Efficient sealing is ... in conjunction with screw or clip-down hot lid thermal ...
... Polystyrene covers can be used ... Ridged covers for stacking of ... covers for use with automated ... ridged and non-ridged, are available ...
Biology Products: