Navigation Links
New finding in cell migration may be key to preventing clots, cancer spread
Date:1/14/2010

Researchers at the University of Illinois at Chicago College of Medicine have discovered how cells in the body flatten out as they adhere to internal bodily surfaces, the first step in a wide range of important processes including clot formation, immune defense, wound healing, and the spread of cancer cells.

Their study is published in the January 15 issue of Science.

Xiaoping Du, UIC professor of pharmacology, and his colleagues were trying to better understand how platelets in the blood form clots. Clots that form in blood vessels can lead to heart attack and stroke.

To form clots, platelets flatten out to seal the wound and to bind to each other, a process called "spreading." Spreading is the first step in a number of cell processes, Du says.

In order for cells to move, they must adhere and spread onto the extracellular matrix, a scaffolding of fibers that supports cells. Only then is the cell able to crawl along -- whether it be an immune cell moving toward a wound, or a cancer cell invading neighboring tissue.

Adhesion to the extracellular matrix is mediated by cell receptors called integrins. Du's team "found the mechanism for the transmission of the signal to spread" by the integrins, he said.

The integrin molecule spans the cell membrane, with a portion of the integrin inside the cell and another part outside.

When the outside part of the integrin molecule binds to the matrix, a signal is sent inside the cell via a G protein, a type of protein involved in cell signaling but that was not previously known to interact with integrins.

Du and his colleagues found that the G protein G-alpha-13 binds to the inner side of the integrin molecule when the outside portion binds to the matrix. G-alpha-13 then inhibits a molecule called RhoA, which normally allows the cell to maintain a spherical shape. When RhoA is inhibited by G-alpha-13, the cell is able to flatten out and spread onto the matrix.

Because the factors involved in this first step in spreading are common to virtually all cells, Du believes that the mechanism is likely universal.

"Understanding these fundamental processes has the potential to allow us to develop drugs to treat thrombosis, stroke and heart attack," he said, and may lead to drugs that could stop cancer cells from migrating.


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Finding that 1-in-a-billion that could lead to disease
2. First finding of a metabolite in 1 sex only
3. Embryonic stem cell strategy advanced with UCSF finding
4. New prostate cancer research findings
5. Reprogramming the debate: stem-cell finding alters ethical controversy
6. Lupus gene finding prompts call for more DNA samples
7. K-State researchers findings on E. coli
8. UVA reports surprising findings related to myotonic muscular dystrophy
9. Womens health-related scientific findings presented by University of Pittsburgh researchers
10. Findings a step toward making new optical materials
11. Finding God with biocomplexity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2016)... --> --> Competitive Landscape Analysis ... Physical infrastructure and Perimeter Surveillance & Detection Systems ... and the continuing migration crisis in the Middle ... led visiongain to publish this unique report, which is crucial ... & security companies in the border security market and the ...
(Date:3/15/2016)... ALBANY, New York , March 15, 2016 ... a new market report published by Transparency Market Research "Digital ... Growth, Trends and Forecast 2015 - 2023," the global digital ... at US$ 731.9 Mn in 2014 and is forecast to ... to 2023. Growth of micro, small and medium enterprises (MSMEs) ...
(Date:3/14/2016)... 2016 NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ... March 21 st .  The commercials will air on Bloomberg ... on the Street show. --> NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... 2016 According to a ... "Separation Systems for Commercial Biotechnology Market - Global ... 2015 - 2023", the separation systems for commercial ... in 2014 and is projected to expand at ... to reach US$ 19,227.8 Mn in 2023. ...
(Date:4/29/2016)... TURIN, Italy , April 29, 2016 ... version 5.11, the latest update to its industry-leading treatment ... has shown that Monaco version ... Users can now attain calculation speeds up to four ... Monaco . With the industry,s gold standard ...
(Date:4/28/2016)... ... 28, 2016 , ... Next week on May 5 at ... technologies for tissue stem cell counting and expansion to gene-editing scientists and other ... CRISPR-based Genome Engineering in Burlington, Massachusetts. , The attention of most gene-editing scientists ...
(Date:4/27/2016)... ... April 27, 2016 , ... ... technology at the Spring 2016 Marijuana Business Conference and Expo. Shimadzu’s high-performance instruments ... heavy metals, and more. Expo attendees can stop by booth 1021 to learn ...
Breaking Biology Technology: