Navigation Links
New finding in cell migration may be key to preventing clots, cancer spread
Date:1/14/2010

Researchers at the University of Illinois at Chicago College of Medicine have discovered how cells in the body flatten out as they adhere to internal bodily surfaces, the first step in a wide range of important processes including clot formation, immune defense, wound healing, and the spread of cancer cells.

Their study is published in the January 15 issue of Science.

Xiaoping Du, UIC professor of pharmacology, and his colleagues were trying to better understand how platelets in the blood form clots. Clots that form in blood vessels can lead to heart attack and stroke.

To form clots, platelets flatten out to seal the wound and to bind to each other, a process called "spreading." Spreading is the first step in a number of cell processes, Du says.

In order for cells to move, they must adhere and spread onto the extracellular matrix, a scaffolding of fibers that supports cells. Only then is the cell able to crawl along -- whether it be an immune cell moving toward a wound, or a cancer cell invading neighboring tissue.

Adhesion to the extracellular matrix is mediated by cell receptors called integrins. Du's team "found the mechanism for the transmission of the signal to spread" by the integrins, he said.

The integrin molecule spans the cell membrane, with a portion of the integrin inside the cell and another part outside.

When the outside part of the integrin molecule binds to the matrix, a signal is sent inside the cell via a G protein, a type of protein involved in cell signaling but that was not previously known to interact with integrins.

Du and his colleagues found that the G protein G-alpha-13 binds to the inner side of the integrin molecule when the outside portion binds to the matrix. G-alpha-13 then inhibits a molecule called RhoA, which normally allows the cell to maintain a spherical shape. When RhoA is inhibited by G-alpha-13, the cell is able to flatten out and spread onto the matrix.

Because the factors involved in this first step in spreading are common to virtually all cells, Du believes that the mechanism is likely universal.

"Understanding these fundamental processes has the potential to allow us to develop drugs to treat thrombosis, stroke and heart attack," he said, and may lead to drugs that could stop cancer cells from migrating.


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related biology news :

1. Finding that 1-in-a-billion that could lead to disease
2. First finding of a metabolite in 1 sex only
3. Embryonic stem cell strategy advanced with UCSF finding
4. New prostate cancer research findings
5. Reprogramming the debate: stem-cell finding alters ethical controversy
6. Lupus gene finding prompts call for more DNA samples
7. K-State researchers findings on E. coli
8. UVA reports surprising findings related to myotonic muscular dystrophy
9. Womens health-related scientific findings presented by University of Pittsburgh researchers
10. Findings a step toward making new optical materials
11. Finding God with biocomplexity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/26/2016)... BANGALORE, India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a ... ), and Onegini today announced a partnership to ... banking solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... banks to provide their customers enhanced security to ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... NEWPORT BEACH, Calif. , June 23, 2016 /PRNewswire/ ... offering new biological discoveries to the medical community, has ... and co-founder Matthew Nunez . "We ... provide us with the capital we need to meet ... funding will essentially provide us the runway to complete ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... a new line of intelligent tools designed, tuned and optimized exclusively for Okuma ... 12–17 in Chicago. The result of a collaboration among several companies with expertise ...
(Date:6/22/2016)... , June 22, 2016  According to Kalorama ... generation sequencing (NGS) market include significant efforts in ... sequencers.  More accessible and affordable sequencers, say the ... demand for consumables including sample prep materials.  The ... for Sample Preparation for Next Generation Sequencing (NGS) ...
Breaking Biology Technology: